Using biointegrated LEDs to stimulate nerves

This CT scan of a rat shows a small device implanted around the bladder. The device — developed by scientists at Washington University School of Medicine, the University of Illinois and Northwestern University — uses light signals from tiny LEDs to activate nerve cells in the bladder and control problems such as incontinence and overactive bladder. (Image: Gereau lab)

A team of neuroscientists and engineers has developed a tiny, implantable device that has potential to help people with bladder problems bypass the need for medication or electronic stimulators.

The team — from Washington University School of Medicine in St. Louis, the University of Illinois at Urbana-Champaign, and the Feinberg School of Medicine at Northwestern University in Chicago — created a soft, implantable device that can detect overactivity in the bladder and then use light from tiny, biointegrated LEDs to tamp down the urge to urinate.

The device works in laboratory rats and one day may help people who suffer incontinence or frequently feel the need to urinate.

The new strategy is outlined in an article published Jan. 2 in the journal Nature.

Overactive bladder, pain, burning and a frequent need to urinate are common and distressing problems. For about 30 years, many with severe bladder problems have been treated with stimulators that send an electric current to the nerve that controls the bladder. Such implants improve incontinence and overactive bladder, but they also can disrupt normal nerve signaling to other organs.

“There definitely is benefit to that sort of nerve stimulation,” said Robert W. Gereau IV, the Dr. Seymour and Rose T. Brown Professor of Anesthesiology at Washington University School of Medicine, and one of the study’s senior investigators. “But there also are some off-target side effects that result from a lack of specificity with those older devices.”

Gereau and his colleagues developed the new device in hopes of preventing such side effects.

During a minor surgical procedure, they implant a soft, stretchy belt-like device around the bladder. As the bladder fills and empties, the belt expands and contracts. The researchers also inject proteins called opsins into the animals’ bladders. The opsins are carried by a virus that binds to nerve cells in the bladder, making those cells sensitive to light signals. This allows the researchers to use optogenetics — the use of light to control cell behavior in living tissue — to activate those cells.

Using blue-tooth communication to signal an external hand-held device, the scientists can read information in real time and, using a simple algorithm, detect when the bladder is full, when the animal has emptied its bladder, and when bladder emptying is occurring too frequently.

“When the bladder is emptying too often, the external device sends a signal that activates micro-LEDs on the bladder band device, and the lights then shine on sensory neurons in the bladder. This reduces the activity of the sensory neurons and restores normal bladder function,” Gereau said.

The researchers believe a similar strategy could work in people. Devices for people likely would be larger than the ones used in rats, and could be implanted without surgery, using catheters to place them through the urethra into the bladder.

“We’re excited about these results,” said John A. Rogers, the study’s other senior investigator and a professor of materials science and engineering at Northwestern. “This example brings together the key elements of an autonomous, implantable system that can operate in synchrony with the body to improve health: a precision biophysical sensor of organ activity; a noninvasive means to modulate that activity; a soft, battery-free module for wireless communication and control; and data analytics algorithms for closed-loop operation.”

Closed-loop operation essentially means the device delivers the therapy only when it detects a problem. When the behavior is normalized, the micro-LEDs are turned off, and therapy can be discontinued.

Gereau and Rogers expect to test similar devices in larger animals. The researchers also believe the strategy could be used in other parts of the body — treating chronic pain, for example, or using light to stimulate cells in the pancreas to secrete insulin. One hurdle, however, involves the viruses used to get light-sensitive proteins to bind to cells in organs.

“We don’t yet know whether we can achieve stable expression of the opsins using the viral approach and, more importantly, whether this will be safe over the long term,” Gereau said. “That issue needs to be tested in preclinical models and early clinical trials to make sure the strategy is completely safe.”

See Also

Learn more: Tiny, implantable device uses light to treat bladder problems

 

 

The Latest on: Biophysical sensor

[google_news title=”” keyword=”biophysical sensor” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]

via Google News

 

The Latest on: Biophysical sensor
  • Sailing meets science in new Pacific data-gathering project
    on May 8, 2024 at 7:51 pm

    New Zealand Geographic and the Cawthron Institute have launched Citizens of the Sea, which aims to map the health and biodiversity of the Pacific at a larger scale than before. Evgeny Glazov of ...

  • Scientists spin century-old Murray’s Law to make better bio-inspired materials
    on May 7, 2024 at 2:32 am

    By reinterpreting ‘Murray’s Law,’ a biophysical principle that’s been around for a century, they’ve developed a new materials theory. This theory holds promise for various functional materials of the ...

  • Bio-inspired materials' potential for efficient mass transfer boosted by a new twist on a century-old theory
    on May 7, 2024 at 2:00 am

    The natural vein structure found within leaves—which has inspired the structural design of porous materials that can maximize mass transfer—could unlock improvements in energy storage, catalysis, and ...

  • Sensors Bolster Army Prowess
    on May 2, 2024 at 5:00 pm

    The Terrain Commander from Textron Corporation provides the basis for the U.S. Army's unattended ground sensor (UGS) Future Combat Systems. The sensor assembly is equipped with a variety of optical, ...

  • Biophysical Aspects of Nucleic Acid Therapeutics
    on April 9, 2024 at 5:00 pm

    This special issue is a collection of perspective articles highlighting how chemical synthesis, computational chemistry, modelling, biophysical and structural techniques can improve our understanding ...

  • Tiny Sensors (IMAGE)
    on March 19, 2024 at 3:00 am

    The sensor network is designed so the chips can be implanted into the body or integrated into wearable devices. Each submillimeter-sized silicon sensor mimics how neurons in the brain communicate ...

  • Philips Hue Secure contact sensor review: Hue goes there?
    on March 15, 2024 at 3:20 am

    Tightly integrated with both the Hue app as well as Hue’s new security cams, the Hue contact sensor can warn you when a monitored door or window is unexpectedly opened or closed—and if there ...

  • Sensors & Diagnostics
    on October 16, 2023 at 4:46 am

    Our initial APC waiver will come to an end at the end of June 2024. Article processing charges will apply to all articles submitted to Sensors & Diagnostics from 1 July 2024 onwards provided that, ...

  • Oxford: Sensors tracking all vehicle movements along streets
    on July 17, 2023 at 8:31 am

    More traffic monitoring of Oxford’s smaller roads needs to take place, an Oxford city councillor has said. Emily Kerr, who represents St Mary’s and the Green Party, has called for the ...

  • Sensors and probes articles from across Nature Portfolio
    on November 16, 2021 at 9:48 pm

    Sensors and probes are molecules that report ... observing rapid evolution of trait correlations through changes in the biophysical properties of these proteins. For accurate single cell analyses ...

via  Bing News

 

What's Your Reaction?
Don't Like it!
0
I Like it!
0
Scroll To Top