Our lab aims to reverse glial scar back to normal neural tissue by gene delivery and/or chemical treatment.
Recently, We have discovered a cocktail of small molecules that can reprogram human brain astroglial cells into neuron-like cells after eight-to-ten days of chemical treatment.The small molecule induced neurons could survive for more than five months in cell culture, where they formed functional synaptic networks. When injected in the brains of living mice,the reprogrammed human neurons were integrated into the neural circuits and survived there for at least one month.
The new technology opens the door to the future development of drugs that patients with brain disorders could take as pills to regenerate neurons!
Learn more: Chemically transform human glial cells into neurons for brain repair
The Latest on: Gene delivery
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The Latest on: Gene delivery
- Clinical trial shows CRISPR gene editing has exciting potential to treat a rare form of blindnesson May 8, 2024 at 9:28 am
By Dr. Liji Thomas, MD Retinal degeneration can be inherited or acquired. In the former case, it is an incurable and progressive condition. A recent study published in The New England Journal of ...
- Improving Gene Therapy for Lung Diseaseon May 8, 2024 at 5:59 am
Drug delivery researchers at Oregon State University have created a device that could enhance gene therapy for patients with inherited lung diseases like cystic fibrosis, according to a study led by ...
- CRISPR Therapeutics Highlights ASGCT Oral Presentation and Announces New Programs Utilizing In Vivo Gene Editing Approachon May 8, 2024 at 4:00 am
ASGCT presentation demonstrates lipid nanoparticle (LNP) mediated delivery to the eye in the context of editing of the myocilin (MYOC) gene as a potential treatment for glaucoma - - Expands pipeline ...
- NANITE AWARDED $1.8M TO DEVELOP AI-DRIVEN GENE THERAPY FOR HIVon May 8, 2024 at 3:00 am
Nanite, Inc. today announced a $1.8M grant from the Bill & Melinda Gates Foundation to design and optimize polymeric delivery vehicles to deliver DNA-encoded therapeutics.
- Injectable drug delivery market poised for 8.6% CAGR growth until 2029on May 7, 2024 at 10:26 pm
Revenue for the global injectable drug delivery market is set to grow by $1139.4b at a compound ... contributing to the industry’s expansion. ALSO READ: Gene panel market to reach $3.23b growth until ...
- ASGT 2024: Gene Therapy Delivery and Development Dominates Opening Workshopon May 7, 2024 at 3:15 pm
In one of the opening workshops at ASGCT 2024, topics around delivery methods for gene therapies and approaches to expand the gene editing toolbox dominated the discussion. The quality of the ...
- Nanoparticle researchers develop microfluidic platform for better delivery of gene therapy for lung diseaseon May 7, 2024 at 7:14 am
Drug delivery researchers at Oregon State University have developed a device with the potential to improve gene therapy for patients with inherited lung diseases such as cystic fibrosis.
- Mass General Brigham Gene and Cell Therapy researchers present key findings at ASGCTon May 6, 2024 at 4:59 pm
Leaders and investigators from the Mass General Brigham Gene and Cell Therapy Institute, a hub of innovation dedicated to accelerating groundbreaking research, conducting clinical trials and ...
- Experimental gene therapy restores some vision in patients with inherited blindnesson May 6, 2024 at 7:32 am
For her entire life, college student Olivia Cook had only a small degree of central vision. It was as if she was watching the world through a straw hole, and in dimly lit places, she could not make ...
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