Medicine against parasites like Tapeworms and Giardia, contains a substance that kills Prostate- and colon cancer.
Cancer researchers at the University of Bergen (UiB) have in the recent years experienced with hundreds of known drugs, to see how they influence cancer cells.
Recently they found that a substance in medicine against parasites like Giardia and Tapeworms, acts like tailored medicine against prostate- and colon cancer.
“We discovered that this specific substance is blocking the signalling pathway in the cancer cells, and make them stop growing. It is not often that researchers discover a substance that targets specific molecules as precisely as this one, ” says Professor Karl-Henning Kalland at the Department of Clinical Science, at UiB. He is the leader of the Kalland´s Research Group.
The study is published in Nature Chemical Biology.
Hyperactive cells
The researchers Yi Qu and Xisong Ke at Kalland team saw that the cells in prostate- and colon cancer contain high amounts of activated Beta-catenin. Activation of this protein makes the cells go amok and divides at high tempo. In addition, Beta-catenin makes the cancer cells more resistant and more able for survival.
In the study, Qu and Ke discovered that it was the substance NTZ (nitazoxanide), a well known and approved anti-parasite drug, that decompose the activated Beta-catenin.
“We are the first researchers who have mapped the complex molecular mechanisms involved in this process,” Kalland says.
Recycling old medicines
Experiments with well-known drugs show that a medicine may have different and unknown targets in the cells.
“The advantage of testing already approved drugs, is that we know they work in the human body and have no serious side effects, which means that a future treatment may happen quicker,” Kalland explains.
Strengthen the immune system
NTZ attacks cancer celles by hindering the activated Beta-catenin. It appears that this hindering also stimulates central parts of the immune system, that attacks cancer cells.
“At the moment, we are working on how to strengthen our on going immune therapy against prostate cancer by using the mechanisms we discovered of the NTZ,” Kalland says.
Kalland and his research-team is in the first phase in a clinical trial using immune therapy against prostate cancer.
Learn more: Tapeworm drug fights Prostate Cancer
The Latest on: Immune therapy
[google_news title=”” keyword=”immune therapy” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]- Combination immunotherapy treatment enhances immune response for people with malignant gliomason May 9, 2024 at 9:19 pm
Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an ...
- Researchers discover benefits of adding immune-boosting agent to personalized cancer vaccineon May 9, 2024 at 9:18 am
Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an ...
- Supercharging immune cells to battle blood cancer: Advances in cancer immunotherapyon May 9, 2024 at 6:51 am
The research suggests that targeting CD300A could be a promising addition to immune checkpoint-based cancer immunotherapy. The ability to invigorate NK cell-based treatments against HMs offers new ...
- Supercharging immune cells to battle blood cancer: Breakthrough in cancer immunotherapyon May 8, 2024 at 5:00 pm
A new study reveals a groundbreaking approach to immunotherapy, demonstrating that blocking the interaction between the CD300A receptor and phosphatidylserine (PS) significantly enhances the ability ...
- How new immunotherapy is helping treat advanced stage 4 melanomaon May 8, 2024 at 12:48 pm
Oncologists say the single-dose immunotherapy is currently approved for those with advanced stage 4 melanoma, who have not had success with other treatments. The process works by surgically removing a ...
- Biotech CEL-SCI gets FDA go-ahead to conduct investigational cancer immunotherapy studyon May 8, 2024 at 11:18 am
Listen to this article CEL-SCI Corporation, the Vienna, Virginia-based biotechnology company with operations in Baltimore, Wednesday received approval from the U.S. Food and Drug Administration to ...
- Can Vitamin D Improve Cancer Immunotherapy?on May 8, 2024 at 6:30 am
Your diet could impact your cancer treatment’s progress; a new preclinical study suggests more vitamin D could improve responses to checkpoint inhibitors.
- Many Patients With Advanced MCC Not Receiving Immunotherapyon May 5, 2024 at 9:36 pm
Despite improved survival rates and guideline recommendations, many eligible patients with metastatic Merkel cell carcinoma are not receiving immunotherapy.
- Immunotherapy: A Beacon of Hope in Cancer Treatmenton May 4, 2024 at 2:25 pm
Cancer, a disease that has plagued humanity for centuries, has finally met its match in immunotherapy, a revolutionary treatment that harnesses the power of the immune system to combat this deadly ...
- Ketone supplement may boost immunotherapy against prostate canceron May 2, 2024 at 9:00 am
Researchers have found that adding a pre-ketone supplement to immunotherapy boosted its effectiveness against prostate cancer in mouse models.
via Google News and Bing News
Go deeper with Bing News on:
Immune system
- Tattoos Still Won’t Boost Your Immune System
Does the repeated stress on your immune system from getting tattoo after tattoo make you better able to fight off infections? No, no it does not.
- New COVID-19 Variant ‘FLiRT’ Capable of Evading Immune Systems, Infect Fully Vaccinated Individuals: Experts
At a time when the transmissibility rate of this new variant of COVID-19 is at its peak, experts have revealed that FLiRT is capable of evading the immune system, which means a fully vaccinated person ...
- Immune Cells: A Hidden Trigger for Anxiety, Depression, and Alzheimer’s Disease
Research indicates that regulatory T cells (Tregs) might stabilize mood and prevent depression, with their depletion linked to increased anxiety and cognitive issues in Alzheimer’s models. Regulatory ...
- GPS-like system shows promise as HIV vaccine strategy to elicit critical antibodies
A team has developed a vaccine approach that works like a GPS, guiding the immune system through the specific steps to make broadly neutralizing antibodies against HIV.
- Researchers discover benefits of adding immune-boosting agent to personalized cancer vaccine
Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an ...
Go deeper with Google Headlines on:
Immune system
[google_news title=”” keyword=”immune system” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
Immune therapy
- Combination immunotherapy treatment enhances immune response for people with malignant gliomas
Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an ...
- Researchers discover benefits of adding immune-boosting agent to personalized cancer vaccine
Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an ...
- Supercharging immune cells to battle blood cancer: Advances in cancer immunotherapy
The research suggests that targeting CD300A could be a promising addition to immune checkpoint-based cancer immunotherapy. The ability to invigorate NK cell-based treatments against HMs offers new ...
- Supercharging immune cells to battle blood cancer: Breakthrough in cancer immunotherapy
A new study reveals a groundbreaking approach to immunotherapy, demonstrating that blocking the interaction between the CD300A receptor and phosphatidylserine (PS) significantly enhances the ability ...
- How new immunotherapy is helping treat advanced stage 4 melanoma
Oncologists say the single-dose immunotherapy is currently approved for those with advanced stage 4 melanoma, who have not had success with other treatments. The process works by surgically removing a ...
Go deeper with Google Headlines on:
Immune therapy
[google_news title=”” keyword=”immune therapy” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]