Study Highlights
- A DNA vaccine helped lower blood pressure for up to six months, reduced tissue damage to the heart and blood vessels associated with hypertension in rats.
- If future research shows the vaccine is a viable treatment option in humans, it could improve high blood pressure levels.
A vaccine may one day help lower blood pressure for up to six months, according to new research in the American Heart Association’s journal Hypertension.
The study in rats may eventually provide a novel alternative to treat high blood pressure in people, who would not need to take a pill everyday.
“The potential of a vaccine for hypertension offers an innovative treatment that could be very effective for the control of non-compliance which is one of the major problems in the management of hypertensive patients,” said Hironori Nakagami M.D., Ph.D., study co-author and professor at Osaka University in Japan.
Researchers have designed a DNA vaccine that targets angiotensin II ? a hormone that raises blood pressure by causing blood vessels to constrict. This narrowing can increase your blood pressure and force your heart to work harder.
In the study, researchers immunized hypertensive rats three times at two-week intervals with needleless injections. The vaccine not only lowered blood pressure for up to six months, but also reduced tissue damage to the heart and blood vessels associated with hypertension. There were no signs of damage to other organs such as the kidney or liver.
The DNA vaccine works similar to common ACE inhibitor blood pressure medications which help blood vessels relax and open up, which, in turn, lowers blood pressure. Other types of vaccines have been tested for hypertension (e.g. a peptide vaccine), but didn’t have lasting effects and some had undesirable side effects.
The ultimate goal of an anti-hypertensive vaccine is to achieve perfect blood pressure control by improving drug compliance through the vaccine. In addition, in the developing countries like Africa and south Asia, anti-hypertensive drugs such as ARB (angiotensin receptor blockade) are expensive. A DNA vaccine may provide cheaper and effective anti-hypertensive treatments in such countries, researchers said.
Read more: Future vaccine may help lower blood pressure long-term
The Latest on: DNA vaccine
[google_news title=”” keyword=”DNA vaccine” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: DNA vaccine
- New mRNA vaccine fights brain cancer in children by triggering attack from withinon May 9, 2024 at 5:00 am
RNA, or mRNA, cancer vaccine, that can deliver treatments more effectively in children who have brain cancer and teach their immune systems to fight back.
- Q&A: AstraZeneca's COVID-19 vaccine and blood clots—what you need to knowon May 1, 2024 at 9:24 am
Pharmaceutical giant AstraZeneca admitted in court this week that its COVID-19 vaccine can cause a rare but deadly blood-clotting condition that has become the central focus of a class-action lawsuit ...
- DNA vaccine against zika performs well in tests on miceon April 18, 2024 at 9:29 am
“Most vaccines use an attenuated or inactivated form of the virus they’re designed to combat. DNA vaccines are more advanced. The technology has evolved over the past 30 years to become a ...
- AACR: Cancer vaccines get a reintroduction as readouts support 'path forward' for the techon April 9, 2024 at 9:30 pm
We took the time to really understand the critical elements for what success will require,” he said Geneos’ vaccine is DNA-based with a cytokine adjuvant IL-12 and an efficient delivery system ...
- Geneos cancer vaccine shrinks liver tumors in small trialon April 7, 2024 at 1:32 pm
There were no serious adverse events. Unlike many vaccine candidates based on messenger RNA (mRNA) technology, the Geneos treatment is a DNA vaccine in which the genetic code of the mutated ...
- AstraZeneca's Medimmune Terminates DNA Cancer Vaccine Program With Inovioon March 14, 2024 at 8:36 am
MedImmune Limited, a unit of AstraZeneca Plc (NASDAQ: AZN), has notified Inovio Pharmaceuticals Inc (NASDAQ: INO) to terminate the DNA cancer vaccine development program agreement. Under the ...
- Here’s why Pfizer, Moderna COVID vaccines do not affect DNA, experts sayon January 10, 2024 at 10:58 am
Federal regulators are blasting Florida Surgeon General Joseph Ladapo for pushing what they say are unfounded and misleading safety concerns about Pfizer and Moderna’s COVID-19 vaccines.
- The dangers of DNA vaccinationon August 9, 2023 at 10:01 am
To the editor—DNA vaccination has entered clinical trials, and may ultimately be used on a large scale. It involves the injection of naked DNA that encodes antigens under the control of a ...
- Advancing the development of vaccines through recombinant technologyon May 3, 2023 at 5:00 pm
especially in areas where access to medical care and vaccination programs may be limited. DNA and mRNA vaccine delivery systems have stepped into the spotlight since the COVID-19 pandemic ...
- Development and Manufacturing Strategy for DNA-Based Drug/Vaccine Candidates with Live Q&Aon April 5, 2023 at 2:30 pm
DNA vaccines have emerged as a promising technology for developing COVID-19 vaccines due to their ability to be quickly designed and manufactured after obtaining the pathogen or cancer antigen genome ...
via Bing News