Scientists at acib and the University of Natural Resources Vienna develop world’s first continuous purification method for valuable drugs. This will lead to significantly reduced production costs and to cheaper pharmaceuticals that are affordable for non-privileged health care systems.
Imagine a dear relative suffering from cancer – and you could not afford a treatment because the drugs are too expensive. The Austrian Centre of Industrial Biotechnology (acib) developed a method with the power to reduce production costs of highly valued drugs significantly.
Without antibodies we would be at the mercy of pathogens or cancer cells. Therapeutic antibodies are used as passive vaccines, for cancer therapy or for controlling autoimmune diseases such as multiple sclerosis. According to “bccresearch.com” the global market for antibody drugs was worth nearly 70 billion USD in 2014 and should rise to 122 billion USD until 2019.
Two thirds of those molecules are produced biotechnologically using Chinese hamster ovary cells (CHO). Actually the major cost factor for industry is purification using “protein A” affinity chromatography where tens of thousands of liters of culture volume have to be processed annually. About 80 % of the production costs fall upon purification.
Here this new purification method comes into play. Researchers from the Austrian Centre of Industrial Biotechnology (acib) and the University of Natural Resources and Life Sciences Vienna (BOKU) developed the world’s first downstream processing method for recombinant antibodies from clarified CHO cultures. From a technical view, the purification method combines a Calcium-Phosphate flocculation with a subsequent cold ethanol precipitation in a tubular reactor realized as a double-pipe heat exchanger that is operated in counter-current flow.
A feasibility study exemplified by the purification of immune globulin G (IgG) shows that the continuous method can compete with “protein A” affinity chromatography in terms of yield and outperforms chromatography according to the speed of operation. A further advantage is that the operation parameters can be easily transferred from the actually used batch to the continuous approach. In combination with a prior concentration step the new method is perfect for purification of low titer supernatants. “Our method shows great potential as a new platform technology for the pharmaceutical industry”, says Prof. Alois Jungbauer, who is in negotiations with several international companies about building pilot plants.
Read more: First Method for Continuous Purification of Valuable Antibodies
The Latest on: Drug production
[google_news title=”” keyword=”Drug production” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Drug production
- How to find more information about a drug that your doctor prescribedon May 9, 2024 at 9:18 am
If you want to know more about a drug, Health Canada provides information online through several websites. However, some information appears to be getting harder to find.
- Why domestic U.S. production for lifesaving drugs is mandatory or innovation will die | Gueston May 9, 2024 at 8:50 am
Opinion: The BIOSECURE Act is a bill in Congress that aims to prevent Chinese manufacturers from accessing U.S. federal funding.
- A New Bid to Legalize All Drugs in New Zealandon May 9, 2024 at 7:10 am
We need to reject the very concept of prohibition to undo its harms. To this end, I helped create a new coalition to pressure our government.
- Drug supplies for millions would be jeopardized by U.S. crackdown on China biopharma industry, trade group sayson May 9, 2024 at 6:12 am
U.S. legislation that would sever ties with Chinese drugmakers would jeopardize the drug supply for millions of American patients if it’s passed, BIO says.
- Pfizer to Settle 10K Lawsuits Over Drug Linked to Cancer, Costing Company Millionson May 9, 2024 at 4:07 am
Big Pharma giant Pfizer confirmed on Wednesday that it will settle more than 10,000 lawsuits over allegations that the company ...
- 5 Weight-Loss Drug Stocks To Watchon May 8, 2024 at 10:05 pm
Weight-loss drugs like Ozempic and Zepbound are taking the pharmaceutical industry by storm. Investors want in.
- Researchers target spermidine production to combat emerging drug resistance in Salmonellaon May 8, 2024 at 1:41 pm
Food-borne diseases like typhoid, caused by Salmonella Typhimurium, are a severe threat to public health, especially in India. The indiscriminate use of antibiotics has allowed this bacterium to ...
- Targeting spermidine production to combat emerging drug resistance in Salmonellaon May 7, 2024 at 5:00 pm
In a recent study published in Redox Biology, researchers at IISc have pinpointed how the Salmonella bacterium uses a key molecule called spermidine to shield itself from the onslaught of the host’s ...
- AI Supercharges Fentanyl Production And Distribution, Study Findson April 27, 2024 at 4:00 am
AI’s power is by no means limited to drug manufacturing and we should now begin the process of understanding the positive and negative possibilities of AI technologies.” Dr. Grzybowski and his ...
- Mexico's chief detective apologizes for saying his country is the 'champion' of fentanyl productionon April 25, 2024 at 5:00 pm
Gallo said Mexican cartels have launched industrial-scale production of meth in many states throughout the country and now export the drug around the world. “Believe me, methamphetamine ...
via Bing News