There are thousands of drugs that silence many thousands of cancer-causing genetic abnormalities.
Some of these drugs are in use now, but many of these drugs are sitting on shelves or could be used beyond the disease for which they were originally approved. Repurposing these drugs depends on matching drugs to targets. A study recently published in the journal Bioinformatics describes a new database and pattern-matching algorithm that allows researchers to evaluate rational drugs and drug combinations, and also recommends a new drug combination to treat drug-resistant non-small cell lung cancer.
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The Latest on: Matching drugs to targets
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The Latest on: Matching drugs to targets
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- Drug Targetson August 16, 2023 at 2:29 am
Being able to accurately predict drug–target interactions (DTIs) and drug–target binding affinity (DTBA) is crucial in early drug development and during drug repurposing endeavors. Here, we look at ...
- Novel cancer-drug strategy could hit notorious proteinson March 8, 2023 at 6:33 am
One notoriously difficult-to-drug target is the protein KRAS ... Astellas scientists can mix and match the various tools in their arsenal to design optimal compounds — as they did with ASP3082.
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