VIDEO: How to stop leaks — the way blood does

Harnessing the principle that allows blood to clot, MIT researchers are working on new synthetic materials to plug holes.

When you get a cut, blood starts to flow from the wound. But very quickly, complex biochemical processes spring into action, creating a scaffolding of molecules to block the hole, and then building up an impervious clot to stanch the flow.

That process relies on a set of molecules that constantly flow through the body’s veins and arteries, just waiting to spring into action when needed. When their job is done, they dissolve back into the blood, awaiting their next repair job.

A team of MIT researchers has analyzed the process and found, for the first time, exactly how the different molecular components work together to block the flow of blood from a cut. Now, they are working on applying that knowledge to the development of synthetic materials that could be used to control different kinds of liquid flows, and could lead to a variety of new self-assembling materials.

The research is published this week in the online journal Nature Communications, in a paper co-authored by MIT assistant professor of materials science and engineering Alfredo Alexander-Katz, graduate student Hsieh Chen, and six other researchers in the United States, Germany and Austria.

One of the surprising things the team found out is that the increased flow rate caused by a wound automatically triggers the reaction that plugs the hole: The faster the flow, the more effectively it works. That’s a counterintuitive finding, since faster flows usually stir things up rather than causing them to clump together.

The way the molecules in the bloodstream react to a leak “is something very freaky,” Alexander-Katz says. “Part of it is chemistry, and part of it is mechanical, which has to do with the flow itself.”

The key molecule, he explains, is a biopolymer — a long, chainlike structure — called the von Willebrand factor (vWF), named for a disease in which it is suppressed in the bloodstream. This molecule normally flows through the bloodstream in a rolled-up form in which it is essentially inactive.

However, “as soon as you stretch [vWFs], they become sticky,” Alexander-Katz says. He compares the reaction to a roll of adhesive tape: It’s only when you pull the tape out from the roll that the sticky part is exposed and begins to attach to things. In the case of these molecules in the blood, in an increased rate of flow, he says, “you stretch them out, and they become sticky and begin sticking to platelets.” The vWFs begin to form a network over the cut — a mixture of the sticky molecules and platelets — that forms a plug within seconds. Over time, additional cells accumulate to form a clot.

If this process were uncontrolled, such plugs would form constantly in the bloodstream, Alexander-Katz says. To counteract that, another kind of molecule also circulates: a kind of “molecular scissors,” he says, that “comes around and cuts [the plugs] to pieces.”

Most of the time, the clumping and snipping remain in balance, so no clots form. But when the flow rate increases, the vWF molecules stretch and grow stickier, and the “molecular scissors” can’t keep up — so the plug builds up.

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via MIT

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