Super resolution microscopy is a technique that can see beyond the diffraction of light and provides unprecedented views of cells and their interior structures and organelles.
An EPFL team has developed a technique that can perform both 3D super resolution microscopy and fast 3D phase imaging in a single instrument.
This unique 4D microscope combines a sensitivity and high time resolution of phase imaging with the specifically and high spatial resolution of fluorescence microscopy. This allows the direct visualization and Analysis of subcellular structures in living cells without labeling.
These technical advances enable high-resolution visualization of the formation of pathological alpha-synuclein aggregates in hippocampal neurons. It is hoped that it will become a regular workhorse for neuroscience and biology.
Learn more: Super-resolution microscopy in both space and time
The Latest on: Super resolution microscopy
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The Latest on: Super resolution microscopy
- A better view with new mid-infrared nanoscopyon April 17, 2024 at 8:02 pm
A team has constructed an improved mid-infrared microscope, enabling them to see the structures inside living bacteria at the nanometer scale. Mid-infrared microscopy is typically limited by its low ...
- Improved mid-infrared nanoscopy enables 30 times clearer view of the insides of bacteriaon April 17, 2024 at 8:03 am
A team at the University of Tokyo have constructed an improved mid-infrared microscope, enabling them to see the structures inside living bacteria at the nanometer scale. Mid-infrared microscopy is ...
- STORM Microscopy: Single-Molecule Localization for Nanoscale Imaging of Biological Structureson April 15, 2024 at 1:09 pm
Stochastic Optical Reconstruction Microscopy (STORM) is a super-resolution imaging technique that allows researchers to visualize biological structures and processes at the nanoscale. It overcomes the ...
- STED Microscopy: Revolutionizing Nanoscale Imaging in Biology and Beyondon April 15, 2024 at 1:09 pm
Stimulated Emission Depletion (STED) microscopy is a super-resolution imaging technique that overcomes the diffraction limit of conventional optical microscopy. It enables the visualization of ...
- Advanced microscopy technique offers a new look inside cellson April 11, 2024 at 7:34 am
Imagine tuning into a football game, but all of the players are invisible except for the two quarterbacks. Without being able to see the orchestrated movements of the full teams, this would be a very ...
- Super-Resolution Microscopy Can Be Super-Accessibleon April 9, 2024 at 9:26 am
To bring single-molecule localization microscopy to everyday researchers, laboratories can upgrade existing systems or deploy all-new platforms.
- Artificial intelligence enhances super-resolution microscopyon April 3, 2024 at 12:30 pm
A joint project between the Center for Advanced Systems Understanding ( CASUS) at Germany's Helmholtz-Zentrum Dresden-Rossendorf, Imperial College London and University College London has used ...
- Unraveling the mysteries of the presynapse with super resolution microscopyon March 20, 2024 at 7:35 am
Shanley Longfield, a Ph.D. student in the Meunier lab, explained that she used super resolution microscopy, simultaneously tracking key proteins and synaptic vesicles, to make this discovery.
- Super-Resolution Microscopy: Capturing the Nano-Worldon February 28, 2024 at 8:00 am
which makes imaging samples smaller than 200 nm almost impossible with conventional microscopy. Super resolution microscopy breaks through the diffraction limit, allowing scientists and researchers to ...
- Super-resolution microscopy harnesses digital display technologyon February 14, 2024 at 1:43 pm
In the ever-evolving realm of microscopy, recent years have witnessed ... system "DMD-3DSIM," combining digital display with super-resolution imaging, allowing scientists to see cellular ...
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