Drugs that combat ageing may be available within five years, following landmark work led by an Australian researcher.
The work, published in the March 8 issue of Science, finally proves that a single anti-ageing enzyme in the body can be targeted, with the potential to prevent age-related diseases and extend lifespans.
The paper shows all of the 117 drugs tested work on the single enzyme through a common mechanism. This means that a whole new class of anti-ageing drugs is now viable, which could ultimately prevent cancer, Alzheimer’s disease and type 2 diabetes.
“Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others,” says the lead author of the paper, Professor David Sinclair, from UNSW Medicine, who is based at Harvard University. “In effect, they would slow ageing.”
The target enzyme, SIRT1, is switched on naturally by calorie restriction and exercise, but it can also be enhanced through activators. The most common naturally-occurring activator is resveratrol, which is found in small quantities in red wine, but synthetic activators with much stronger activity are already being developed.
Although research surrounding resveratrol has been going for a decade, until now the basic science had been contested. Despite this, there have already been promising results in some trials with implications for cancer, cardiovascular disease and cardiac failure, type 2 diabetes, Alzheimer’s and Parkinson’s diseases, fatty liver disease, cataracts, osteoporosis, muscle wasting, sleep disorders and inflammatory diseases such as psoriasis, arthritis and colitis (inflammatory bowel disease).
“In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster,” says Professor Sinclair, a geneticist with the Department of Pharmacology at UNSW.
The technology was sold to pharmaceutical giant GlaxoSmithKline in 2008. Four thousand synthetic activators, which are 100 times as potent as a single glass of red wine, have been developed – the best three are in human trials.
“Our drugs can mimic the benefits of diet and exercise, but there is no impact on weight,” says Professor Sinclair, who suggests the first therapeutic to be marketed will be for diabetes.
There have been limited trials in people with type 2 diabetes and the skin inflammatory disease, psoriasis. There were benefits to the metabolism in the first group and a reduction in skin redness in the second.
The drugs can be administered orally, or topically. So far, there have been no drugs developed targeting ageing skin, but one major skin care range has developed a crème with resveratrol in it.
The Latest Bing News on:
Anti-ageing drug
- Underground drug trafficking operation linked to ‘colourful’ clinic owner, court hearson March 29, 2024 at 1:07 am
Police seized hundreds of vials of testosterone, human growth hormone and anabolic steroids, 17 luxury cars worth more than $3 million and a safe of cash in raids.
- Is your kid asking for anti-aging products? A Tucson skincare expert weighs in on the trendon March 26, 2024 at 9:01 pm
Doctors say kids are becoming obsessed with skincare, with social media driving the beauty trend. Instead of helping young skin, experts say some of the anti-aging ingredients can be harmful.
- Global Complementary and Alternative Medicine for Anti Aging & Longevity Industry is expected to generate US$347.7 Billion in revenue By 2032 | FMIon March 26, 2024 at 4:55 am
The Global Complementary and Alternative Medicine for Anti-Aging and Longevity Industry, estimated at $44.6 billion in 2021, is expected to increase at a CAGR of 24.4% from 2022 to 2032. As the world ...
- Why Do We Age? Scientists Are Figuring It Out.on March 19, 2024 at 5:00 pm
who is involved with two companies pursuing anti-aging drugs. Changes in cellular energy can affect other aspects of a cell’s health, including epigenetics, Dr. Dillin said. Damaged mitochondria ...
- Innovent's anti-VEGF drug matches Eylea in phase 2 eye disease trialon March 19, 2024 at 7:36 am
Innovent’s anti-VEGF drug held its own against Regeneron and Bayer’s blockbuster eye disease therapy Eylea in a phase 2 trial.
- How a cheap, generic drug became a darling of longevity enthusiastson March 15, 2024 at 11:56 am
Rapamycin, a drug for transplant patients, has extended the lives of animals but is unproven in humans. That hasn’t stopped people from trying it.
- Tech moguls and longevity gurus are using a $2 organ transplant pill to reverse AGINGon March 15, 2024 at 8:50 am
Despite a lack of evidence that it works in humans, that hasn’t stopped many from calling it a ‘proven anti-aging drug’, with online pharmacies and doctors in clinics prescribing it more and ...
The Latest Google Headlines on:
Anti-ageing drug
[google_news title=”” keyword=”Anti-ageing drug” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
[/vc_column_text]
The Latest Bing News on:
Anti-aging drug
- Underground drug trafficking operation linked to ‘colourful’ clinic owner, court hearson March 29, 2024 at 1:07 am
Police seized hundreds of vials of testosterone, human growth hormone and anabolic steroids, 17 luxury cars worth more than $3 million and a safe of cash in raids.
- Sport clinic made $100k a week on steroids, court toldon March 29, 2024 at 12:56 am
A sports medicine clinic owner has been arrested after police alleged he used his business as a front for a multimillion-dollar steroid trafficking business.
- Revolutionizing Health and Wellness: Urban Wellness Group Unveils Innovative Anti-Aging and Sleep Enhancement Technologieson March 28, 2024 at 10:31 pm
Urban Wellness Group, a pioneering wellness provider, is proud to announce its official launch of new anti-aging and sleep enhancement treatments to southeast Portland .
- Tracy Morgan Sets the Record Straight on Experience With Ozempicon March 28, 2024 at 1:29 pm
Though Tracy Morgan recently said he gained 40 pounds while on Ozempic, the comedian explained what really happened while taking the type 2 diabetes drug.
- Anti-aging elixir could be hiding in 'indestructible' tardigrades, say scientists who found microscopic creature's proteins slow cell damageon March 28, 2024 at 9:23 am
That is because they have proteins that form gels inside of cells and slow down life processes down cell damage - and the gel could be an anti-aging elixir ... expanding access to lifesaving drugs for ...
- Vietnam Dermatology Drugs Market Mastering the Audience Odyssey Effective Targeting Techniqueson March 27, 2024 at 9:34 pm
This country research report on Vietnam Dermatology Drugs Market offers comprehensive insights into the market landscape, customer intelligence, and competitive strategies in the Vietnam market. The ...
- Tracy Morgan Says He Gained 40 Lbs While Using a Weight Loss Drug: ‘I Out-Ate Ozempic’on March 20, 2024 at 2:58 pm
Ozempic is a drug intended for patients with type 2 diabetes, but it has recently been used to accelerate weight loss. Morgan was diagnosed with diabetes in 1996, and he eventually received a kidney ...
- Tracy Morgan says he ‘gained 40 pounds’ on weight-loss drugs: I can ‘out-eat Ozempic’on March 20, 2024 at 9:12 am
The comedian first confessed to Ozempic use in an August 2023 interview, saying, “It cuts my appetite in half. Now I only eat half a bag of Doritos.” ...
- Celebrities who have used buzzy drugs like Ozempic for weight loss — and who's denied iton March 20, 2024 at 7:25 am
Jimmy Kimmel said: "When I look around this room, I can't help but wonder 'Is Ozempic right for me?'" while presenting the 2023 Oscars.
- Whoopi Goldberg Reveals the Weight Loss Drug She Used to Slim Downon March 19, 2024 at 1:12 pm
Whoopi Goldberg is sharing insight into her weight loss journey. The View cohost recently revealed she used Mounjaro—a type 2 diabetes medication—to slim down after gaining weight in 2021. "I will ...
The Latest Google Headlines on:
Anti-aging drug
[google_news title=”” keyword=”Anti-aging drug” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]