Drugs that combat ageing may be available within five years, following landmark work led by an Australian researcher.
The work, published in the March 8 issue of Science, finally proves that a single anti-ageing enzyme in the body can be targeted, with the potential to prevent age-related diseases and extend lifespans.
The paper shows all of the 117 drugs tested work on the single enzyme through a common mechanism. This means that a whole new class of anti-ageing drugs is now viable, which could ultimately prevent cancer, Alzheimer’s disease and type 2 diabetes.
“Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others,” says the lead author of the paper, Professor David Sinclair, from UNSW Medicine, who is based at Harvard University. “In effect, they would slow ageing.”
The target enzyme, SIRT1, is switched on naturally by calorie restriction and exercise, but it can also be enhanced through activators. The most common naturally-occurring activator is resveratrol, which is found in small quantities in red wine, but synthetic activators with much stronger activity are already being developed.
Although research surrounding resveratrol has been going for a decade, until now the basic science had been contested. Despite this, there have already been promising results in some trials with implications for cancer, cardiovascular disease and cardiac failure, type 2 diabetes, Alzheimer’s and Parkinson’s diseases, fatty liver disease, cataracts, osteoporosis, muscle wasting, sleep disorders and inflammatory diseases such as psoriasis, arthritis and colitis (inflammatory bowel disease).
“In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster,” says Professor Sinclair, a geneticist with the Department of Pharmacology at UNSW.
The technology was sold to pharmaceutical giant GlaxoSmithKline in 2008. Four thousand synthetic activators, which are 100 times as potent as a single glass of red wine, have been developed – the best three are in human trials.
“Our drugs can mimic the benefits of diet and exercise, but there is no impact on weight,” says Professor Sinclair, who suggests the first therapeutic to be marketed will be for diabetes.
There have been limited trials in people with type 2 diabetes and the skin inflammatory disease, psoriasis. There were benefits to the metabolism in the first group and a reduction in skin redness in the second.
The drugs can be administered orally, or topically. So far, there have been no drugs developed targeting ageing skin, but one major skin care range has developed a crème with resveratrol in it.
The Latest Bing News on:
Anti-ageing drug
- Underground drug trafficking operation linked to ‘colourful’ clinic owner, court hearson March 29, 2024 at 1:28 am
A sports medicine and anti-ageing clinic owner with a “colourful” past has been accused of running an elaborate drug trafficking operation, including paying an interstate doctor $2000 a week for ...
- Revolutionizing Health and Wellness: Urban Wellness Group Unveils Innovative Anti-Aging and Sleep Enhancement Technologieson March 28, 2024 at 10:31 pm
Urban Wellness Group, a pioneering wellness provider, is proud to announce its official launch of new anti-aging and sleep enhancement treatments to southeast Portland .
- 4 arrested after drug bust in Birminghamon March 28, 2024 at 6:08 pm
Damondre Juan Miller, age 26, of Birmingham, was charged with loitering for drug purpose and resisting arrest, with a bond of $1,000 each. Miller has been released from the Jefferson County Jail.
- 34 held in anti-drug drives in Dhakaon March 28, 2024 at 9:57 am
As part of the anti-drugs drives in the capital, members of the Dhaka Metropolitan Police arrested a total of 34 people on charges of selling and consuming drugs during the last 24 hours till 6:00am ...
- Anti-aging elixir could be hiding in 'indestructible' tardigrades, say scientists who found microscopic creature's proteins slow cell damageon March 28, 2024 at 9:23 am
That is because they have proteins that form gels inside of cells and slow down life processes down cell damage - and the gel could be an anti-aging elixir ... expanding access to lifesaving drugs for ...
- Parsons High School Students Find Success With Anti-Drug Videoon March 26, 2024 at 10:25 am
A pair of Parsons High School students create an award-winning anti-drug video. PHS students Brody Wright and Syrus Clairmont submitted an entry for the Elks Club ...
- Investing in the Booming Cow Colostrum Market: Seizing Opportunities in Athlete Nutrition and Anti-Aging Trendson March 26, 2024 at 2:50 am
Cow Colostrum Market The expected value of the world market for cow colostrum in 2022 is US$1.40 billion. Cow colostrum is used as a nutritive supplement to aid athletes in developing their immune ...
- Evangeline drug bust yields 2 lbs. of meth, 6 pot plantson March 25, 2024 at 12:12 pm
The search led to the seizure of approximately 2.2 lbs. of methamphetamines, six marijuana plants, and $13,300 in cash.
- How to ‘switch on’ your anti-ageing genes – and live longeron March 23, 2024 at 4:00 am
You’ve probably referred to them negatively – blaming them for your weight, bad habits or thinning hair. But while you can’t change the genetic hand you’ve been dealt, you actually have more control ...
- Woodland school district shows anti-drug filmon March 21, 2024 at 5:39 pm
The Woodland Joint Unified School District invites families and students to Pioneer High School for a free movie screening addressing youth substance use and abuse on Wednesday, March ...
The Latest Google Headlines on:
Anti-ageing drug
[google_news title=”” keyword=”Anti-ageing drug” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
[/vc_column_text]
The Latest Bing News on:
Anti-aging drug
- Businessman accused of trafficking steroids as police seize luxury cars and cash in Melbourneon March 29, 2024 at 1:18 am
Luxury cars, cash and property worth almost $4m has been seized in Melbourne as a businessman was arrested for allegedly selling steroids and prescription medication.
- Underground drug trafficking operation linked to ‘colourful’ clinic owner, court hearson March 29, 2024 at 1:07 am
Police seized hundreds of vials of testosterone, human growth hormone and anabolic steroids, 17 luxury cars worth more than $3 million and a safe of cash in raids.
- Tracy Morgan Sets the Record Straight on Experience With Ozempicon March 28, 2024 at 1:29 pm
Though Tracy Morgan recently said he gained 40 pounds while on Ozempic, the comedian explained what really happened while taking the type 2 diabetes drug.
- Tracy Morgan Says He Gained 40 Lbs While Using a Weight Loss Drug: ‘I Out-Ate Ozempic’on March 20, 2024 at 2:58 pm
Ozempic is a drug intended for patients with type 2 diabetes, but it has recently been used to accelerate weight loss. Morgan was diagnosed with diabetes in 1996, and he eventually received a kidney ...
- Celebrities who have used buzzy drugs like Ozempic for weight loss — and who's denied iton March 20, 2024 at 8:00 am
Jimmy Kimmel said: "When I look around this room, I can't help but wonder 'Is Ozempic right for me?'" while presenting the 2023 Oscars.
- Why Do We Age? Scientists Are Figuring It Out.on March 19, 2024 at 5:00 pm
who is involved with two companies pursuing anti-aging drugs. Changes in cellular energy can affect other aspects of a cell’s health, including epigenetics, Dr. Dillin said. Damaged mitochondria ...
- Oprah Winfrey Shares Why Her Use of Weight Loss Drugs Provided “Hope”on March 18, 2024 at 9:53 pm
Ozempic is no laughing matter for the comedian. Handler revealed her "anti-aging doctor" prescribed her the medication without realizing what the drug was. "I didn't even know I was on it," she said ...
- How a cheap, generic drug became a darling of longevity enthusiastson March 15, 2024 at 12:55 pm
The drug is going mainstream as an anti-aging treatment, even though rapamycin’s regulatory approval is for treating transplant patients. There is no evidence that it can extend human life. Subscribe ...
- Tech moguls and longevity gurus are using a $2 organ transplant pill to reverse AGINGon March 15, 2024 at 8:50 am
Despite a lack of evidence that it works in humans, that hasn’t stopped many from calling it a ‘proven anti-aging drug’, with online pharmacies and doctors in clinics prescribing it more and ...
The Latest Google Headlines on:
Anti-aging drug
[google_news title=”” keyword=”Anti-aging drug” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]