Scalable model supports patient-specific treatments, advanced study of blood disorders
A team led by researchers at Tufts University School of Engineering and the University of Pavia has reported development of the first three-dimensional tissue system that reproduces the complex structure and physiology of human bone marrow and successfully generates functional human platelets. Using a biomaterial matrix of porous silk, the new system is capable of producing platelets for future clinical use and also provides a laboratory tissue system to advance study of blood platelet diseases.
“There are many diseases where platelet production or function is impaired,” says Alessandra Balduini, M.D., research associate professor in the Department of Biomedical Engineering at Tufts, associate professor at the Department of Molecular Medicine at the University of Pavia and co-corresponding author on the paper. “New insight into the formation of platelets would have a major impact on patients and healthcare. In this tissue system, we can culture patient-derived megakaryocytes — the bone marrow cells that make platelets — and also endothelial cells, which are found in bone marrow and promote platelet production, to design patient-specific drug administration regimes.”
The new system can also provide an in vitro laboratory tissue system with which to study mechanisms of blood disease and to predict efficacy of new drugs–providing a more precise and less costly alternative to in vivo animal models.
Read more: 3-D engineered bone marrow makes functioning platelets
The Latest on: 3D tissue system
[google_news title=”” keyword=”3D tissue system” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: 3D tissue system
- Researchers uncover regulatory system that regulates branching patterns in lung epithelial tissueon March 28, 2024 at 8:06 am
Branching patterns are prevalent in our natural environment and the human body, such as in the lungs and kidneys. For example, specific genes that express growth factor proteins are known to influence ...
- Global 3D Cell Culture Market Projected to Reach USD 3.21 Billion by 2030, Driven by Technological Advancementson March 28, 2024 at 7:44 am
Dublin, March 28, 2024 (GLOBE NEWSWIRE) -- The "Global 3D Cell Culture Market Size, Share & Trends Analysis Report by Technology (Scaffold Based, Scaffold Free, Bioreactors, Microfluidics, Bioprinting ...
- The Role of Lasers in 3D Printing Organs: Innovations and Implicationson March 22, 2024 at 9:00 am
Laser-based 3D bioprinting is advancing organ transplantation with high-precision, viable constructs for addressing organ shortages.
- Researchers add swept illumination to open-top light-sheet microscopeon March 20, 2024 at 12:50 pm
Researchers have incorporated a swept illumination source into an open-top light-sheet microscope to enable improved optical sectioning over a larger area of view. The advance makes the technique more ...
- 3D-printed skin closes wounds and contains hair follicle precursorson March 4, 2024 at 9:49 am
Fat tissue holds the key to 3D printing layered living skin and potentially hair ... Ozbolat and his team are the first to intraoperatively print a full, living system of multiple skin layers, ...
- Scientists achieve world's first by 3D printing functional human brain tissueon February 7, 2024 at 7:32 am
The researchers published a new study in the scientific journal Cell Stem Cell, and according to the paper, the team created the 3D-printed brain tissue using horizontal layers of "bio-ink" gel.
- 3D printing technology for tissue: Researchers combine hydrogels and fiberson February 7, 2024 at 6:55 am
This is achieved by using 3D (bio) printing with an integrated ... the artificial production of biological tissues. The combination of a hydrogel system with a fiber system reduces the processing ...
- U-OI/CT: A preclinical in vivo 2D/3D/4D optical imaging systemon January 13, 2024 at 5:55 pm
The seamless in-line mode enables 3D/4D OI/CT acquisitions on a single-floor standing platform and offers more accurate reconstruction and quantification of deep tissues and dark organs.
- Peek behind the paper: Three dimensional visualization and analysis of dendritic spines in human brain tissueon December 20, 2023 at 4:00 pm
Our study shows, for the first time, an optically acquired 3D image of dendritic ... to observe cell morphologies in their tissue context, democratizing structural–molecular–functional correlative ...
- Elastomeric Polymer Scaffolds for 3D Cell and Tissue Cultureon October 11, 2023 at 9:48 pm
Using 3D cell culture systems in the laboratory will power more relevant investigations, improving drug development efficiency, and reducing costs. In medicine, tissue engineering is set to ...
via Bing News