Brigham and Women’s Hospital

Brigham and Women’s Hospital (BWH, “The Brigham”) is the largest hospital of the Longwood Medical and Academic Area in Boston, Massachusetts, USA.

3D-bioprinted tissues can be frozen and stored until needed

Could a self-injecting pill deliver results comparable to standard injections?

Are patients receptive to interacting with robots designed to evaluate symptoms in a contact-free way?

Treating musculoskeletal injuries with a handheld 3D bioprinter

Using light to help break down ingestible medical devices

Developing a once-a-month oral contraceptive

Investigators designed a capsule that can be swallowed once a month, reside in the stomach and release a drug to prevent pregnancy   Daily oral contraceptive pills allow women to manage their fertility, but this method of contraception relies on a user remembering to take her pill at the same time every day. In a multi-national

Developing a once-a-month oral contraceptive

Delivering insulin, therapeutics and perhaps even vaccines . . . by pill

Coated pill carries microneedles that deliver insulin and other drugs to the lining of the small intestine. Many drugs, especially those made of proteins, cannot be taken orally because they are broken down in the gastrointestinal tract before they can take effect. One example is insulin, which patients with diabetes have to inject daily or

Delivering insulin, therapeutics and perhaps even vaccines . . . by pill

Machine learning can help predict the risk of heart failure in diabetes patients

Investigators used artificial intelligence to identify top 10 variables that can predict, with a high degree of accuracy, future heart failure among patients living with diabetes Heart failure is an important potential complication of type 2 diabetes that occurs frequently and can lead to death or disability. Earlier this month, late-breaking trial results revealed that

Machine learning can help predict the risk of heart failure in diabetes patients

Can gut bacteria prevent and even reverse food allergies?

Study finds altered gut microbiota in infants with food allergy; oral therapy to replenish bacteria prevented food allergy and suppressed established disease in mice. Every three minutes, a food-related allergic reaction sends someone to the emergency room in the U.S. Currently, the only way to prevent a reaction is for people with food allergies to

Can gut bacteria prevent and even reverse food allergies?

Using sensory nanoparticles to detect disease

Building on new insights about nanoparticles, investigators develop a test for early detection of diseases, including different types of cancer Investigators from Brigham and Women’s Hospital are taking advantage of a unique phenomenon of nanoparticles to develop a test for early detection of different types of diseases, including cancer. Through previous investigations, Morteza Mahmoudi, PhD,

Using sensory nanoparticles to detect disease

Researchers invent a resistance-sensing injection device (needle) that knows where to go

Smart Needle Syringes and hollow needles—among the most feared and most commonly used tools in medical practice—have been around for more than a century. However, the precise insertion of these devices depends largely on the technique and skill of the person delivering the injection. And some anatomical regions, such as the space in the back

Researchers invent a resistance-sensing injection device (needle) that knows where to go

A big move forward towards defeating glioblastoma

New approach using multiple microRNA ‘hitchhikers’ to weaken cancer cells in advance of standard therapy shows promise in preclinical models In cancer therapeutics research, microRNAs–tiny strings of nucleotides that get churned out inside cells–have been a source of both excitement and disappointment. While preclinical studies have found that microRNAs play an important role in cancer

A big move forward towards defeating glioblastoma

Home-based hypertension program helped 81 percent of participants achieve blood pressure control in seven weeks

Pilot study by Brigham investigators finds that an innovative care-delivery program helped 81 percent of participants achieve blood pressure control in seven weeks Hypertension, or high blood pressure, is a widespread clinical problem affecting nearly half of all adults. Despite the serious consequences that can result from hypertension, which puts patients at increased risk for

Home-based hypertension program helped 81 percent of participants achieve blood pressure control in seven weeks

A nanoscale arthritis treatment could administer drugs directly to cartilage potentially healing damaged tissue

Injectable material made of nanoscale particles can deliver arthritis drugs throughout cartilage. Osteoarthritis, a disease that causes severe joint pain, affects more than 20 million people in the United States. Some drug treatments can help alleviate the pain, but there are no treatments that can reverse or slow the cartilage breakdown associated with the disease.

A nanoscale arthritis treatment could administer drugs directly to cartilage potentially healing damaged tissue

Detecting HIV with new cellphone technology

New, affordable mobile device could aid people in developing countries The management of human immunodeficiency virus 1 (HIV), an autoimmune disorder that cripples the immune system by attacking healthy cells, remains a major global health challenge in developing countries that lack infrastructure and trained medical professionals. Investigators from Brigham and Women’s Hospital have designed a

Detecting HIV with new cellphone technology

Genetic engineering sets the stage for a synthetic microbiome

Genetic engineering allows different species of bacteria to communicate with each other in the gut of a living mouse, setting the stage for a synthetic microbiome More than 1,000 species of bacteria have been identified in the human gut, and understanding this incredibly diverse “microbiome” that can greatly impact health and disease is a hot

Genetic engineering sets the stage for a synthetic microbiome

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