Organ-on-a-chip

Tissues cultured in the multi-organ chip (from left to right: skin, heart, bone, liver, and endothelial barrier) maintained their tissue-specific structure and function after being linked by vascular flow. Photo credit: Kacey Ronaldson-Bouchard/Columbia Engineering
Customized to the patient: Novel plug-and-play organ on a chip
Tissues cultured in the multi-organ chip (from left to right: skin, heart, bone, liver, and
This illustration demonstrates the structure of the LF Chip: B cells and T cells were cultured together in the extracellular matrix (ECM)-lined lower channel, and were “fed” via the consistent flow of nutrient-containing medium through the upper channel. This flow is also what appears to have caused the spontaneous assembly of the cells into lymphoid follicles. Credit: Wyss Institute at Harvard University
Significantly speeding up the pace and quality of vaccine creation with a microfluidic Organ Chip – No Animal Testing
This illustration demonstrates the structure of the LF Chip: B cells and T cells were
Google glass meets organs-on-chips

Investigators from Brigham and Women’s Hospital (BWH) have developed hardware and software to remotely monitor

Person-on-a-chip — could eventually be used to repair or replace damaged organs

Researchers at U of T Engineering have developed a new way of growing realistic human

Bioengineers put human hearts on a chip to aid drug screening

When UC Berkeley bioengineers say they are holding their hearts in the palms of their

Cross section of microsystem to study metastasis. Credit: ICMS Visualisation Studio
The concept of organs on a chip opens the possibility of realistically studying human organs without the use of patients or animal testing

Systems of this kind can help to achieve a big reduction in the cost of

Credit: Gang Wang and William Pu/Boston Children's Hospital The series of images shows how inserting modified RNA into diseased cells causes the cells to produce functioning versions of the TAZ protein (from left, green), which correctly localize in the mitochondria (red). When the images are merged to demonstrate this localization, green overlaps with red, giving the third image a yellow color around its edges.
‘Heart disease-on-a-chip’

Harvard scientists have merged stem cell and “organ-on-a-chip” technologies to grow, for the first time,

Microscopic view of the engineered bone with an opening exposing the internal trabecular bony network, overlaid with colored images of blood cells and a supportive vascular network that fill the open spaces in the bone marrow-on-a-chip. Credit: James Weaver, Harvard’s Wyss Institute.
Bone marrow-on-a-chip unveiled – no animal testing needed

The bone marrow-on-a-chip could also be used in the future to maintain a cancer patient’s