
English: A dramatic photo shot of nasal spray in action. A hand sprays a mist of nasal spray droplets on a black background.
(Photo credit: Wikipedia)
Researchers have developed a molecule that is, when administered nasally, extremely effective in preventing the disease caused by all known variants of the SARS-CoV-2 virus. The molecule can be a key tool in preparing for future pandemics, as it is aimed at preventing both the transmission and spread of the virus.
In laboratory animal studies, a molecule known as TriSb92, developed by researchers at the University of Helsinki, has been confirmed as affording effective protection against coronavirus infection. The molecule identifies a region in the spike protein of the coronavirus common to all current variants of the virus and inhibits its functioning.
“When administered nasally, the TriSb92 molecule is extremely effective in preventing infection, and experiments carried out in cell cultures indicate that it also encompasses the very latest variants, including XBB, BF7 and BQ.1.1,” explains Postdoctoral Researcher Anna R. Mäkelä from Professor Kalle Saksela’s research group.
Animal models have also demonstrated that, unlike face masks, the molecule can, when sprayed into the nose, prevent infection even after a few hours of exposure.
According to the researchers, the molecule remains fully functional at room temperature for at least 18 months, making it well suited for use as a nasal spray.
The results have been published in the Nature Communications journal.
Anticipation of future viral variants
While the worst stage of the coronavirus pandemic is, at least for the time being, behind us, nasally administered protection can be a crucial help in preventing the spread of the virus in the future.
“The latest variants effectively avoid the immune protection provided by both vaccines and the COVID-19 disease, and current vaccines are not effective in preventing transmission,” Mäkelä says.
Moreover, the nasal spray can protect those people from serious disease who do not gain sufficient immunity from vaccines, such as immunocompromised individuals and elderly.
According to the researchers, the molecule could also work against future animal-borne close relatives of SARS-CoV-2, which are expected to be the cause of entirely new coronavirus pandemics.
“Since the region in the coronavirus’s spike protein affected by the TriSb92 molecule has remained almost unchanged in all viral variants so far emerged, it can be assumed to be effective also against future SARS-CoV-2 variants,” Mäkelä confirms.
“The easily and inexpensively produced TriSb92 could be a very important first line of defence in curbing such a new pandemic, pending the development, production and distribution of vaccines,” she adds.
A copyable approach
According to the researchers, the sherpabody-technology used is also applicable to the prevention of many other viral diseases, particularly influenza and other respiratory viruses.
“The whole approach stems from a technical solution based on a binder protein platform developed in Finland, which was not originally intended for the development of an antiviral drug. It provides an opportunity for many other new initiatives based on the accurate identification of diseased cells or pathogens in patients,” Mäkelä says.
In the next stage, the molecule must be tested in clinical trials, after which it could be made commercially available.
“Successful commercialisation of the nasal spray could lead to the creation of a thriving Finnish business,” Mäkelä points out.
Original Article: A nasal spray protects against coronavirus infection – Effective also against recent immune-evasive variants
More from: University of Helsinki
The Latest Updates from Bing News
Go deeper with Bing News on:
TriSb92
- Could A Nasal Spray Be Your Next Line Of Defense Against COVID?
The study tested a particular sherpabody called TriSb92 and found that although it couldn't prevent the COVID virus from attaching to cells, it was successful in blocking the virus from its ...
Go deeper with Bing News on:
Sherpabody technology
- Denver Technology News
Ranked by No. of full-time employees in Denver area Ranked by No. of full-time employees in Denver area How tech salaries stack up in Denver and across the U.S. Activate your professional network ...
- Boston Technology News
Boston-based marketing agency Fuseideas is proud to announce the recognition of their creative work… Are you seeking a unique venue for your next corporate event or ...
- The Latest Technology News
Apple unveiled macOS Sonoma at WWDC 2023 yesterday, this new major software update will bring a wide range of new features to the Mac. If you are wondering whether your Mac will be eligible for ...
- Riverbed Technology
Riverbed Technology, Inc. develops applications, websites, networks, data centers, the cloud, and remote offices. It offers visibility, intelligent optimization, and ...
- How the technology behind ChatGPT could make mind-reading a reality
Why? Neuroscientists at the University of Texas in Austin have figured out a way to translate scans of brain activity into words using the very same artificial intelligence technology that powers ...