This is what the articifial skin looks like.
The study was conducted on artificial human skin
By using artificial human skin, a research group from the University of Copenhagen have managed to block invasive growth in a skin cancer model.
The study has been published in Science Signaling and looks at what actually happens when a cell turns into a cancer cell.
“We have been studying one of the cells’ signalling pathways, the so-called TGF beta pathway. This pathway plays a critical role in the cell’s communication with its surroundings, and it controls e.g. cell growth and cell division. If these mechanisms are damaged, the cell may turn into a cancer cell and invade the surrounding tissue,” explains Professor and Team Lead Hans Wandall from the Department of Cellular and Molecular Medicine at the University of Copenhagen.
By using artificial human skin we are past the potentially problematic obstacle of whether results from tests on mice models can be transferred to human tissue.
Under normal circumstances, your skin cells will not just start to invade the hypodermis and wreak havoc. Instead, they will produce a new layer of skin. But when cancer cells emerge, the cells no longer respect the boundaries between skin layers, and they start to invade each other. This is called invasive growth.
Hans Wandall and his colleagues have been studying the TGF beta pathway and applied methods for blocking invasive growth and thus curbing the invasive growth in skin cancer.
“We already have various drugs that can block these signalling pathways and which may be used in tests. We have used some of them in this study,” explains Associate Professor and co-author of the study Sally Dabelsteen from the School of Dentistry.
Hans Wandall and Sally Dabelsteen have worked together with Dr. Zilu Ye and Professor Jesper V. Olsen from the Novo Nordisk Foundation Center for Protein Research at the Faculty of Health and Medical Sciences.
“Some of these drugs have already been tested on humans, and some are in the process of being tested in connection with other types of cancer. They could also be tested on skin cancer specifically,” she says.
Artificial skin is the closest we get to real human skin
The artificial skin used by the researchers in the new study consists of artificial, genetically manipulated human skin cells. Skin cells are produced on subcutaneous tissue made of collagen. This makes the cells grow in layers, just like real human skin.
Unlike mice models, the skin model, which is another word for artificial skin, allows researchers to introduce artificial genetic changes relatively quickly, which provide insight into the systems that support skin development and renewal.
This way they are also able to reproduce and follow the development of other skin disorders, not just skin cancer.
“By using artificial human skin we are past the potentially problematic obstacle of whether results from tests on mice models can be transferred to human tissue. Previously, we used mice models in most studies of this kind. Instead, we can now conclude that these substances probably are not harmful and could work in practice, because the artificial skin means that we are closer to human reality,” says Hans Wandall.
The artificial skin used by the researchers resembles the skin used to test cosmetics in the EU, which banned animal testing in 2004. However, artificial skin does not allow the researchers to test the effect of a drug on the entire organism, Hans Wandall points out. Skin models like the one used here have been used by cosmetics companies since the mid-1980s.
“We can study the effect focussing on the individual organ – the skin – and then we reap experiences with regard to how molecules work, while we seek to determine whether they damage the structure of the skin and the healthy skin cells,” he says.
Original Article: Artificial human skin paves the way to new skin cancer therapy
More from: University of Copenhagen
The Latest Updates from Bing News
Go deeper with Bing News on:
Artificial human skin
- What is artificial skin? How it’s grown and how it could help skin cancer sufferers, having been developed to treat burn victims
A dressing developed decades ago prompts the growth of tissue 'like skin', rather than scar tissue, in patients. It has since been used to treat burn victims Today, artificial skin is used to test ...
- I Let AI Choose My Makeup For A Week
While I’m aware of the ongoing discourse surrounding AI art, including the lawsuits and ethical debates, my curiosity is a lot stronger than my apprehension about it. So that’s why I decided to let AI ...
- Levi's faces backlash after announcing it will use AI to 'increase the number and diversity' of models: 'Unethical on so many levels'
"Y'all could just pay a diverse group of models that show how your jeans actually fit on people, but instead you're just... faking it?" ...
- Levi’s faces backlash after announcing it will use AI to ‘increase the number and diversity’ of models
The controversy surrounding artificial intelligence ... size and skin tone to be more inclusive. However, the news has sparked a pretty intense debate about what this could mean for the future of ...
- What’s AI Got to Do with Fashion?
With the advent of OpenAI’s ChatGPT, GitHub Copilot, and Google’s Bard, generative artificial ... skin tone, eye color, jaw shape, you name it) and that provide companies with the perfect ...
Go deeper with Bing News on:
- Alexa Bliss: WWE star urges sunbed safety after skin cancer scare
That's the message WWE wrestler Alexa Bliss had for herself after undergoing treatment for skin cancer. The 31-year-old, real name Lexi Cabrera, posted an Instagram photo over the weekend showing ...
- Global Skin Cancer Diagnostics Market [2023-2030] | Current Status and Future Prospects
The MarketWatch News Department was not involved in the creation of this content. Mar 28, 2023 (The Expresswire) -- Global "Skin Cancer Diagnostics Market" (2023-2030) research report provides an ...
- Research reveals how incurable skin cancer resists treatment – study
Scientists have found out how some skin cancers stop responding to treatment at the end of life. The findings allow researchers to see how melanoma evolves to spread to the brain and the liver. The ...
- Research autopsies reveal how incurable skin cancer resists treatment
Scientists have determined how some skin cancers stop responding to treatment at the end of life. An in-depth analysis of 14 patients who died from incurable melanoma has revealed that changes to the ...
- Risk for skin cancer higher for adults with atopic dermatitis
"In conclusion, our findings support an increased risk of melanoma, SCC, and BCC development in adult patients with AD regardless of AD severity," the authors write. "More mechanistic studies are ...