A photoacoustic sensor could help clinicians diagnose tumors, organ malfunctions and more.
Photo by Xiaoxiang Gao for the Jacobs School of Engineering at UC San Diego
A team of engineers at the University of California San Diego has developed an electronic patch that can monitor biomolecules in deep tissues, including hemoglobin. This gives medical professionals unprecedented access to crucial information that could help spot life-threatening conditions such as malignant tumors, organ dysfunction, cerebral or gut hemorrhages and more.
“The amount and location of hemoglobin in the body provide critical information about blood perfusion or accumulation in specific locations. Our device shows great potential in close monitoring of high-risk groups, enabling timely interventions at urgent moments,” said Sheng Xu, a professor of nanoengineering at UC San Diego and corresponding author of the study.
The paper, “A photoacoustic patch for three-dimensional imaging of hemoglobin and core temperature,” is published in the December 15, 2022 issue of Nature Communications.
Low blood perfusion inside the body may cause severe organ dysfunctions and is associated with a range of ailments, including heart attacks and vascular diseases of the extremities. At the same time, abnormal blood accumulation in areas such as in the brain, abdomen or cysts can indicate cerebral or visceral hemorrhage or malignant tumors. Continuous monitoring can aid diagnosis of these conditions and help facilitate timely and potentially life-saving interventions.
The new sensor overcomes some significant limitations in existing methods of monitoring biomolecules. Magnetic resonance imaging (MRI) and X-ray-computed tomography rely on bulky equipment that can be hard to procure and usually only provide information on the immediate status of the molecule, which makes them unsuitable for long-term biomolecule monitoring.
“Continuous monitoring is critical for timely interventions to prevent life-threatening conditions from worsening quickly,” said Xiangjun Chen, a nanoengineering PhD student in the Xu group and study co-author. “Wearable devices based on electrochemistry for biomolecules detection, not limited to hemoglobin, are good candidates for long-term wearable monitoring applications. However, the existing technologies only achieve the ability of skin-surface detection.”
The new, flexible, low form-factor wearable patch comfortably attaches to the skin, allowing for noninvasive long-term monitoring. It can perform three-dimensional mapping of hemoglobin with a submillimeter spatial resolution in deep tissues, down to centimeters below the skin, versus other wearable electrochemical devices that only sense the biomolecules on the skin surface. It can achieve high contrast to other tissues. Due to its optical selectivity, it can expand the range of detectable molecules, integrating different laser diodes with different wavelengths, along with its potential clinical applications.
The patch is equipped with arrays of laser diodes and piezoelectric transducers in its soft silicone polymer matrix. Laser diodes emit pulsed lasers into the tissues. Biomolecules in the tissue absorb the optical energy, and radiate acoustic waves into surrounding media.
“Piezoelectric transducers receive the acoustic waves, which are processed in an electrical system to reconstruct the spatial mapping of the wave-emitting biomolecules”, said Xiaoxiang Gao, a postdoctoral researcher in Xu’s lab and co-author of the study.
“With its low-power laser pulses, it is also much safer than X-ray techniques that have ionizing radiation”, said Hongjie Hu, a postdoctoral researcher in the Xu group and study coauthor.
Based on its success so far, the team plans to further develop the device, including shrinking the backend controlling system to a portable-sized device for laser diode driving and data acquisition, greatly expanding its flexibility and potential clinical utility.
They also plan to explore the wearable’s potential for core temperature monitoring. “Because the photoacoustic signal amplitude is proportional to the temperature, we have demonstrated core temperature monitoring on ex-vivo experiments,” Xu said. “However, validating the core temperature monitoring on the human body requires interventional calibration.”
They are continuing to work with physicians to pursue more potential clinical applications.
Original Article: Wearable Skin Patch Monitors Hemoglobin in Deep Tissues
More from: University of California San Diego
The Latest Updates from Bing News
Go deeper with Bing News on:
Wearable photoacoustic sensor
- Wearable Sensors in Vital Health Monitoring
Consequently, wearable technology can be an innovative solution for healthcare problems. Advancements in packaging and fabrication technologies have enabled embedding various microelectronic and ...
- Team uses gold nanowires to develop wearable sensor that measures two bio-signals
used gold nanowires to develop an integrated wearable sensor device that effectively measures and processes two bio-signals simultaneously. Their research findings were featured in Advanced Materials.
- Wearable Sensors Markets: Accelerometers, Pressure & Force, Gyroscopes, Medical - Global Forecast to 2028
Dublin, Nov. 09, 2023 (GLOBE NEWSWIRE) -- The "Wearable Sensors Market by Type (Accelerometers, Pressure & Force Sensors, Gyroscopes, Medical Based Sensors), Application (Wristwear, Eye-Wear ...
- New wearable sensor can monitor glucose, body temp via human sweat
The researchers from Penn State University in the US have now created a new wearable sensor with a laser-modified graphene nanocomposite material. "Sweat is ideal for real-time, continuous and ...
- Jogging and Walking Analysis Using Wearable Sensors ()
Gait analysis is a process of learning the motion of human and animal by using wearable sensor approach and vision approach. This analysis is mainly used in medical and sports field where the study of ...
Go deeper with Bing News on:
- Best Dual Monitor Stands in 2023
Choosing the right monitor stand can be difficult, but do you know what’s even harder? Finding the best dual monitor stands that can accommodate two monitors at once. You want something that ...
- The best credit monitoring services that can help you spot fraud early
The cost of the services mentioned below are up-to-date at the time of publication. Credit monitoring services can provide you with early notice of potential fraud on your credit report ...
- Best Employee Monitoring Software In Canada For December 2023
For this reason, many businesses are turning to employee monitoring software, which can be used to help track productivity and evaluate efficiency, as well as identify threats, gauge the ...
- Monitor stuck at 60Hz in Windows
If your monitor is stuck at 60Hz in Windows, then this post may help. Monitors with high-refresh rates offer a smoother and more responsive computing experience. But recently, some users have ...
- Are Monitor Lizards Dangerous?
Yes, monitor lizards are dangerous in certain circumstances. Monitor lizards will not typically attack humans unless provoked or feeling threatened. Larger species have a powerful, venomous bite, but ...