Basic schematic showing how the [email protected]/I of the present study can function as a PA imaging-guided RA therapeutic. PBNPs: Prussian blue nanoparticles; CIA: collagen-induced arthritis; PL: pulsed laser; PA: photoacoustic; ROS: reactive oxygen species; RA: rheumatoid arthritis.
(Image by SIAT)
The high level of reactive oxygen species (ROS) in the rheumatoid arthritis (RA) microenvironment and its persistent inflammatory nature can promote damage to joints, bones, and the synovium. Strategies that integrate effective RA microenvironment regulation with imaging-based monitoring could lead to improvements in the diagnosis and treatment of RA.
A joint research team from the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences and the University of Texas at Austin has proposed a new strategy that can achieve targeted treatment of rheumatoid arthritis.
The researchers integrated small interfering RNAs (siRNAsT/I) and Prussian blue nanoparticles (PBNPs) to silence the expression of the proinflammatory cytokines TNF-?/IL-6 and scavenge the ROS associated with the RA microenvironment.
The study was published in PNAS on Oct. 18.
To enhance the in vitro and in vivo biological stability, biocompatibility, and targeting capability of the siRNAsT/I and PBNPs, the researchers prepared macrophage membrane vesicles (MMVs) to construct biomimetic nanoparticles, [email protected]T/I.
They found that the [email protected]T/I suppressed TNF-?/IL-6 expression and overcame the hypoxic nature of the RA microenvironment, thus alleviating RA-induced joint damage in a mouse model.
Moreover, near-infrared photoacoustic imaging (PAI) allowed the targeting behavior of the [email protected]T/I to be followed in real time, thus permitting an evaluation of their therapeutic efficacy without the need for invasive procedures.
These findings show that macrophage-biomimetic [email protected]T/I and their analogues assisted by PAI can provide a new strategy for RA diagnosis, treatment, and monitoring.
Original Article: New Strategy Enables Targeted Treatment of Rheumatoid Arthritis
More from: Chinese Academy of Sciences | University of Texas at Austin
The Latest Updates from Bing News
Go deeper with Bing News on:
Rheumatoid arthritis
- Arthritis drug Humira's two-decade reign ends as Amgen launches competing biosimilar
The price of Amgen's rheumatoid arthritis drug called Amjevita is up to 55% less than the widely-prescribed Humira.
- Dear Doctor: Patients with rheumatoid arthritis can try several treatments. Here’s a rundown
ANSWER: Rheumatoid arthritis is relatively common (as much as 1% of the population, with women twice as likely to be affected than men), but it’s a much less common form of arthritis than ...
- Your Good Health: Rheumatoid arthritis can be treated with meds
It’s important for doctors to recognize rheumatoid arthritis early and get patients into treatment quickly before permanent damage to joints occurs ...
- Ask Amy: 37-year-old woman with rheumatoid arthritis is bullied for parking in handicap space
I have a handicap placard for my vehicle, which I try to use only on those days that my rheumatoid arthritis makes it difficult to walk ...
- Rheumatoid Arthritis (RA) Latex Test Kit Market 2023 (New Report): Fairly Valued with a Measurable Competitive Advantage by 91 Pages Research
New research published as the “Rheumatoid Arthritis (RA) Latex Test Kit Market” research report provides an in-depth ...
Go deeper with Bing News on:
Rheumatoid arthritis treatment
- Dear Doctor: Patients with rheumatoid arthritis can try several treatments. Here’s a rundown
ANSWER: Rheumatoid arthritis is relatively common (as much as 1% of the population, with women twice as likely to be affected than men), but it’s a much less common form of arthritis than ...
- Your Good Health: Rheumatoid arthritis can be treated with meds
It’s important for doctors to recognize rheumatoid arthritis early and get patients into treatment quickly before permanent damage to joints occurs ...
- Rheumatoid arthritis can be treated by a variety of medications
When I underwent training, I saw many patients with terrible deformities of their hands, but that is much less common now because there are many new and effective treatments for rheumatoid arthritis.
- Dr. Roach: Rheumatoid arthritis can be treated with a variety of medications
When I underwent training, I saw many patients with terrible deformities of their hands, but that is much less common now because there are many new and effective treatments for rheumatoid arthritis.
- Rheumatoid Arthritis Awareness Day 2023: Date, Theme, History, Significance, Facts & More to Know On This Day
The second of February is recognized each year as Rheumatoid Arthritis Awareness Day. The purpose of the day is to ...
