
University of Minnesota researchers developed a new microfluidic chip with broad applications for detecting viruses, pathogens, bacteria and other biomarkers in liquid samples.
Credit: Laboratory of Nanostructures and Biosensing, University of Minnesota
A University of Minnesota research team has developed a new microfluidic chip for diagnosing diseases that uses a minimal number of components and can be powered wirelessly by a smartphone. The innovation opens the door for faster and more affordable at-home medical testing.
Microfluidics involves the study and manipulation of liquids at a very small scale. One of the most popular applications in the field is developing “lab-on-a-chip” technology, or the ability to create devices that can diagnose diseases from a very small biological sample, blood or urine, for example.
The research is published in Nature Communications, a peer-reviewed, open access, scientific journal published by Nature Research. Researchers are also working to commercialize the technology.
Scientists already have portable devices for diagnosing some conditions — rapid COVID-19 antigen tests, for one. However, a big roadblock to engineering more sophisticated diagnostic chips that could, for example, identify the specific strain of COVID-19 or measure biomarkers like glucose or cholesterol, is the fact that they need so many moving parts.
Chips like these would require materials to seal the liquid inside, pumps and tubing to manipulate the liquid and wires to activate those pumps — all materials difficult to scale down to the micro level. The University of Minnesota team was able to create a microfluidic device that functions without all of those bulky components.
“It’s not an exaggeration that a state-of-the-art, microfluidic lab-on-a-chip system is very labor intensive to put together,” said Sang-Hyun Oh, an electrical and computer engineering professor and senior author of the study. “Our thought was, can we just get rid of the cover material, wires and pumps altogether and make it simple?”
Many lab-on-a-chip technologies work by moving liquid droplets across a microchip to detect the virus pathogens or bacteria inside the sample. The researchers’ solution was inspired by a peculiar real-world phenomenon with which wine drinkers will be familiar — the “legs,” or long droplets that form inside a wine bottle due to surface tension caused by the evaporation of alcohol.
Using a technique pioneered by Oh’s lab, the researchers placed tiny electrodes very close together on a 2 cm by 2 cm chip, which generate strong electric fields that pull droplets across the chip and create a similar “leg” of liquid to detect the molecules within.
Because the electrodes are placed so closely together, with only 10 nanometers of space between, the resulting electric field is so strong that the chip needs less than a volt of electricity to function. This incredibly low voltage requirement allowed the researchers to activate the chip using near-field communication signals from a smartphone, the same technology used for contactless payment in stores.
This is the first time researchers have been able to use a smartphone to wirelessly activate narrow channels without microfluidic structures, paving the way for cheaper, more accessible at-home diagnostic devices.
“This is a very exciting, new concept,” said Christopher Ertsgaard, lead author of the study and a recent University alumnus. “During this pandemic, I think everyone has realized the importance of at-home, rapid, point-of-care diagnostics. And there are technologies available, but we need faster and more sensitive techniques. With scaling and high-density manufacturing, we can bring these sophisticated technologies to at-home diagnostics at a more affordable cost.”
Oh’s lab is working with Minnesota startup company GRIP Molecular Technologies, which manufactures at-home diagnostic devices, to commercialize the microchip platform. The chip is designed to have broad applications for detecting viruses, pathogens, bacteria and other biomarkers in liquid samples.
“To be commercially successful, in-home diagnostics must be low-cost and easy-to-use,” said Bruce Batten, founder and president of GRIP Molecular Technologies. “Low voltage fluid movement, such as what Professor Oh’s team has achieved, enables us to meet both of those requirements. GRIP has had the good fortune to collaborate with the University of Minnesota on the development of our technology platform. Linking basic and translational research is crucial to developing a pipeline of innovative, transformational products.”
Original Article: Researchers develop smartphone-powered microchip for at-home medical diagnostic testing
More from: University of Minnesota
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Microfluidic lab-on-a-chip
- Global Lab-on-a-chip (LOC) Market 2023 Research by Rising Demand Status, Business Statistics, and Growth Forecast to 2029
Jan 31, 2023 (The Expresswire) -- Latest [102 Pages] “Lab-on-a-chip (LOC) Market” Research 2023-2029 demonstrates top countries data, development trends and regional updates of top manufacturers.
- “Spleen-on-a-chip” yields insight into sickle cell disease
Researchers at MIT, Nanyang Technological University in Singapore, the Pasteur Institute in Paris, and other institutions have now designed a microfluidic device, or “spleen-on-a-chip,” that ...
- China’s Top Nuclear-Weapons Lab Used American Computer Chips Decades After Ban
SINGAPORE—China’s top nuclear-weapons research institute has bought sophisticated U.S. computer chips at least a dozen times in the past two and a half years, circumventing decades-old ...
- Organ Tumor-on-a-chip Market Next Big Things | Major Giants Beonchip, Mimetas, Organovo Holdings, Axosim Technologies
Organ-on-a-chip (OOC) technology is a type of microfluidic device that mimics the structure and function of human organs or organ systems. Tumor-on-a-chip (ToC) is a subtype of OOC that ...
- Organs-on-chips: Tech that can help researchers conduct studies closer to real-life conditions
One big reason behind these barriers is the lab models researchers use to develop drugs in the first place. Fewer than 8% of successful animal studies for cancer therapies make it to human clinical ...
Go deeper with Google Headlines on:
Microfluidic lab-on-a-chip
[google_news title=”” keyword=”microfluidic lab-on-a-chip” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
At home medical testing
- Best Post Vas Sperm Test at Home - What's The Easiest Way to Verify a Vasectomy?
Home › Fertility › Best Post Vas Sperm Test At Home Vasectomies are supposed to deliver sexual freedom. You have your sperm-carrying tubes closed and don’t have to worry about pregnancy again, right?
- Hair Loss Test At Home: What’s The Best Way To Diagnose Hair Loss Online?
Home Hair Loss Test Medically reviewed by: Onyinye Elizabeth Mbata, MD It’s tough for anyone to start losing their hair. Even though hair loss is common for those of a certain age, that doesn’t make ...
- The Future of At-Home Testing: Flu, RSV Rapid Tests Are Coming
The FDA says it is confident that at-home rapid tests like those for COVID-19 are forthcoming for flu and RSV.
- AI Can Interpret At-Home COVID-19 Tests, Aid Viral Illness Diagnoses
Computerized symptom screenings can help supplement at-home COVID-19 tests and predict whether symptoms are due to COVID-19, influenza, or RSV.
- Starling Medical’s new urine-testing device turns your toilet into a health tracker
Starling Medical is poised to launch its at-home urine diagnostic patient-monitoring ... into dozens of other health conditions that urine testing can detect, including preeclampsia during pregnancy.
Go deeper with Google Headlines on:
At home medical testing
[google_news title=”” keyword=”at home medical testing” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]