
via National Human Genome Research Institute
Researchers from the University of Sheffield have discovered a new gene therapy pathway that has the potential to protect us against serious life-limiting diseases such as cancer and dementia
Researchers from the University of Sheffield have discovered a new gene therapy pathway that has uncovered an important regulatory mechanism to keep our genome healthy. This pathway has the potential to protect us against serious life-limiting diseases such as cancer and dementia.
Cancer and neurodegeneration are two major health challenges currently affecting the population, and they constitute two sides of the same coin – one is caused by uncontrolled cell proliferation due to genome damage, and the other is caused by excessive genome damage that causes cell death. This new pathway impacts both and offers new therapeutic opportunities to help the fight against disease.
Published in Nature Communications, the research found that when cells in our body read DNA to build proteins, they often make mistakes that can damage our genome, causing disease such as cancer and dementia. However, by investigating how cells fix damage in the DNA to keep us healthy, scientists have discovered the benefits of three proteins working together as a team. The three proteins, called USP11, KEAP1 and SETX, receive instructions from their coach to direct their function in space and time with remarkable harmony, to keep our DNA healthy.
By understanding how cells protect themselves from these mistakes and thus preventing diseases, scientists are able to modify the behaviour of these proteins to promote the health and wellbeing of people.
Findings from this study will enable scientists to develop diagnostic tests and drugs to target one or more of the proteins in the pathway for the early detection and treatment of certain types of cancer and neurological disease. Developing new drugs to regulate the level of one or more of these proteins is expected to offer new treatments for cancer and dementia.
The findings are important and significant, this is because we are now at the stage where we could make drugs to control this modification. This would be useful in killing cells, which is what we do when we treat elderly people for cancer. The other application would be to reduce the level of genome damage, which could be beneficial for other ageing associated disorders like dementia.
Original Article: New gene therapy pathway could protect us from cancer and dementia
More from: University of Sheffield
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Gene therapy pathway
- Gene-editing Treatment Relieves Debilitating Symptomson March 22, 2023 at 7:21 pm
Kiwi patients with a painful and debilitating inherited illness say gene-editing therapy has changed their lives ... which controls a biochemical pathway linked to inflammation. Without sufficient C1 ...
- Calcium-control gene offers new avenue for Alzheimer's disease therapyon March 21, 2023 at 11:28 pm
Nearly six million Americans currently live with Alzheimer’s disease (AD), with the figure set to climb to 13.8 million by 2050. And with promising trials failing close to the finish line, researchers ...
- US FDA to take steps to help gene therapies get accelerated approvalon March 21, 2023 at 7:04 am
The U.S. Food and Drug Administration is moving to optimize the development of gene therapies, including encouraging the use of biomarkers to help get accelerated approval of therapies for serious ...
- FDA to back accelerated approval pathway for gene therapieson March 21, 2023 at 4:43 am
A top FDA official said Monday that the agency needs to consider accelerated approval, commonly used to expedite cancer drug approval, for gene therapies. Read the full story here.
- US FDA official says agency needs to start using accelerated approval for gene therapieson March 20, 2023 at 10:44 pm
Fda: Accelerated approval would be particularly important for ultra-rare diseases, for which there are too few patients to run placebo-controlled studies, the report said, quoting Marks, who heads the ...
Go deeper with Google Headlines on:
Gene therapy pathway
[google_news title=”” keyword=”gene therapy pathway” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
Gene therapy
- DelveInsight Highlights Major Advances, Transformative Therapies, and 260+ Leading Players Wheeling the Gene Therapy Pipeline Landscapeon March 22, 2023 at 11:26 pm
DelveInsight’s 'Gene Therapy Competitive Landscape 2023' report provides comprehensive global coverage of available, marketed, and pipeline Gene therapies ...
- Enabling adeno-associated virus gene therapy despite preexisting humoral immunityon March 22, 2023 at 11:05 am
The use of a monoclonal antibody that reduced circulating IgG levels, led to a decrease in preexisting neutralizing antibodies (NAbs) to adeno-associated virus (AAV). The study, which showed that this ...
- Hemophilia Gene Therapy Market | New Report 2030on March 22, 2023 at 10:17 am
The Global Hemophilia Gene Therapy market is expected to progress at a substantial rate during the forecast period, between 2023 and 2029. In 2023, the market is rising at a stable rate and with the ...
- Researchers uncover a protein deficiency in neurons of patients with neurodegenerative diseases that could be targeted by new gene therapy approachon March 21, 2023 at 11:03 pm
Researchers discovered that a protein called Stathmin-2 is lost in these neurons, which prevents them from regenerating after injury and disrupts their connection with the muscles to control movements ...
- Gene Therapy Approach Fixes the Protein Problems Behind ALSon March 21, 2023 at 3:29 am
Using gene editing, researchers were able to restore stathmin-2 protein levels in mice. Disruption of this protein is a prominent abnormality observed in patients with a spectrum of neurodegenerative ...
Go deeper with Google Headlines on:
Gene therapy
[google_news title=”” keyword=”gene therapy” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]