
Mapping new cohorts of cells of healthy individuals and COVID-19 patients onto a healthy cells reference atlas (Light blue: Healthy reference patients. Blue: New healthy patients. Black: New moderate COVID-19 patients. Red: New severe COVID-19 patients.)
Researchers developed a novel artificial intelligence algorithm for clinical applications called “scArches”. It efficiently compares patients’ cells with a reference atlas of cells of healthy individuals. This enables physicians to pinpoint cells in disease and prioritize them for personalized treatment in each patient.
he Human Cell Atlas is the world’s largest, growing single-cell reference atlas. It contains references of millions of cells across tissues, organs and developmental stages. These references help physicians to understand the influences of aging, environment and disease on a cell – and ultimately diagnose and treat patients better. Yet, reference atlases do not come without challenges. Single-cell datasets may contain measurement errors (batch effect), the global availability of computational resources is limited and the sharing of raw data is often legally restricted.
Researchers from Helmholtz Zentrum München and the Technical University of Munich (TUM) developed a novel algorithm called “scArches”, short for single-cell architecture surgery. The biggest advantage: “Instead of sharing raw data between clinics or research centers, the algorithm uses transfer learning to compare new datasets from single-cell genomics with existing references and thus preserves privacy and anonymity. This also makes annotating and interpreting of new data sets very easy and democratizes the usage of single-cell reference atlases dramatically,” says Mohammad Lotfollahi, the leading scientist of the algorithm
Example COVID-19
The researchers applied scArches to study COVID-19 in several lung bronchial samples. They compared the cells of COVID-19 patients to healthy references using single-cell transcriptomics. The algorithm was able to separate diseased cells from the references and thus enabled the user to pinpoint the cells in need for treatment, for both mild and severe COVID-19 cases. Biological variation between patients did not affect the quality of the mapping process.
Fabian Theis: “Our vision is that in the future we will use cell references as easily as we nowadays do for genome references. In other word, if you want to bake a cake, you usually do not want to try coming up with your own recipe – instead you just look one up in a cookbook. With scArches, we formalize and simplify this lookup process.”
Original Article: AI helps to spot single diseased cells
More from: Helmholtz Zentrum Munchen | Technical University of Munich
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
scArches
- Budget charged me $250 for calibrating a windshield camera. Is that legit?on March 26, 2023 at 8:00 am
This week, we introduce a new consumer advice column, Travel Troubleshooter. Christopher Elliott's long-running, nationally syndicated column fields questions from readers about how to handle issues w ...
- Woman reportedly scratches, kicks police while being dragged off plane for threatening passengeron March 25, 2023 at 12:23 pm
Texas woman hurling obscenities was carried off a plane at Miami International Airport; allegedly attempted to bite officers.
- EU Commission scratches Russia nuclear sanctions planson March 25, 2023 at 6:48 am
The European Commission has abandoned plans to sanction Russia's nuclear sector or its representatives in its next sanctions package, three diplomats told POLITICO on Thursday. The EU executive ...
- Bear scratches itself on treeon March 25, 2023 at 1:57 am
The video, which was captured by Debra Howell, shows the bear leaning against a tree while sliding its back up and down. The bear appears to be enjoying the experience. Credit: Debra Howell via Storyf ...
- Leeds man hits out Morrisons after car 'left with 50 scratches' from car washon March 22, 2023 at 10:00 pm
A Leeds man has been left 'angry' after he claims his car was scratched during a car wash at a Morrisons supermarket. Catalin Badoi, 38, from Morley, claims he goes to the car wash every week to wash ...
Go deeper with Google Headlines on:
scArches
[google_news title=”” keyword=”scArches” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
Single-cell reference atlases
- Single B cell screening: How it aids in antibody discoveryon March 20, 2023 at 2:52 am
This article describes a robust and quick single B cell screening strategy for identifying antibodies with the necessary antigenic selectivity without the arduous requirement for conventional ...
- New computational method to identify location of cell types in a sampleon March 14, 2023 at 5:00 pm
The method combines data from spatial transcriptions and a reference single-cell RNA atlas to create modeling outputs. The resulting models can be used to view cellular substructures, identify ...
- Single-cell sequencing solution seeks to unleash disruptive science, with a vortexeron March 13, 2023 at 8:18 am
A new single-cell encapsulation, lysis and barcoding method of cDNA is faster and requires less equipment, hardware, expense and expertise. It has been demonstrated to be compatible and scalable ...
- News tagged with single cellson February 26, 2023 at 4:00 pm
Cancer cells have an innate randomness in their ability to respond to chemotherapy, which is another tool in their arsenal of resisting treatment, new research led by the Garvan Institute of ...
- Single gene causes sea anemone's stinging cell to lose its stingon February 22, 2023 at 4:00 pm
Single-cell atavism reveals an ancient mechanism of cell type diversification in a sea anemone. Nature Communications , 2023; 14 (1) DOI: 10.1038/s41467-023-36615-9 Cite This Page : ...
Go deeper with Google Headlines on:
Single-cell reference atlases
[google_news title=”” keyword=”single-cell reference atlases” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]