Representative images of the wounds treated with or without gel and oxygen-release microspheres for 16 days.
Jianjun Guan’s lab develops potential drug-free treatment for chronic wounds
About one-fourth of people with diabetes develop painful foot ulcers, which are slow to heal due to low oxygen in the wound from impaired blood vessels and increased inflammation. These wounds can become chronic, leading to poor quality of life and potential amputation.
Jianjun Guan, a professor of mechanical engineering & materials science in the McKelvey School of Engineering at Washington University in St. Louis, has developed a hydrogel that delivers oxygen to a wound, which decreases inflammation, helps remodel tissue and accelerates healing. Results of the work, which were in a mouse model, are published Aug. 28 in Science Advances. Ya Guan, a doctoral student, and Hong Niu, a postdoctoral research associate, both in Guan’s lab, are co-first authors.
“The oxygen has two roles: one, to improve skin cell survival under the low-oxygen condition of the diabetic wound; and two, oxygen can stimulate the skin cells to produce growth factors necessary for wound repair,” Guan said.
Tissues in the body require oxygen to survive and need even more when tissue is injured. While there are several existing treatments for chronic wounds in people with diabetes, the most common treatment is dozens of sessions in a hyperbaric oxygen chamber, but its effectiveness is inconsistent and includes the risk of oxygen toxicity.
Guan’s hydrogel delivers oxygen to the wound using microspheres that gradually release oxygen to interact with the cells through an enzyme on their surface that converts what is inside of the microsphere into oxygen. The oxygen is delivered to the wound over about a two-week period, and inflammation and swelling decrease, prompting healing.
In the mice, wounds treated with the hydrogel containing the oxygen-releasing microspheres had a greater rate of closure than wounds treated with only the gel or those with no treatment. By day 16, the wounds treated with the hydrogel had reduced to 10.7%. Those treated with the gel only were reduced to 30.4%, and those with no treatment had reduced to 52.2%.
In addition, the wounds treated with the hydrogel containing the oxygen-releasing microspheres had the thickest epidermis on day 8, but the thinnest by day 16, indicating the wound was healing and inflammation was reduced.
Over the past 14 years, Guan has been developing this type of gel, which has nearly 70 different functions and chemical structures.
“The gel is a liquid before we put it into the skin tissue, so it is easy to mix in the microspheres,” he said. “Once we put the mixture of the gel and the microspheres into the wound, it becomes a solid because it is temperature-sensitive — at lower temperatures it is a liquid, and at body temperature it’s a solid.”
One risk of delivering oxygen to wounds is delivering too much, which creates reactive oxygen species (ROS), which can damage or kill cells at elevated levels. Guan’s hydrogel is able to scavenge for ROS content and destroy it, eliminating any risk.
Next, Guan’s team plans to use the hydrogel in a large animal model with the expectation of future human clinical trials.
“This represents a new therapeutic approach to accelerating healing of chronic diabetic wounds without drugs,” Guan said. “It also has the potential to treat other diseases in which oxygen is low, such as peripheral artery disease and coronary heart disease.”
Original Article: Oxygen-delivering hydrogel accelerates diabetic wound healing
More from: McKelvey School of Engineering
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Best Places to Buy Colored Contacts for a Whole New Lookon February 13, 2024 at 4:00 pm
Both are flexible and comfortable, but silicone hydrogel lenses generally have better oxygen permeation, which reduces the risk of corneal hypoxia (a condition that occurs when your cornea doesn’t ...
- Innovations And Trends In Contact Lens Technologyon February 12, 2024 at 2:17 pm
Silicone hydrogel contact lenses represent a leap forward, offering higher oxygen permeability compared ... Some smart lenses are designed to deliver medications gradually, offering a novel ...
- Perioperative Optimization of Oxygen Deliveryon February 8, 2024 at 3:59 pm
Abstract and Introduction Physiology of Oxygen Delivery What are the Modalities for Optimization of Oxygen Delivery? Conclusion References What are the Modalities for Optimization of Oxygen Delivery?
- 10 Best Portable Oxygen Concentrators Of 2024on February 8, 2024 at 9:23 am
Commissions we earn from partner links on this page do not affect our opinions or evaluations. Our editorial content is based on thorough research and guidance from the Forbes Health Advisory Board.
- Researchers breathe new life into lung repairon February 6, 2024 at 9:50 am
The lungs’ blood vessels are the pipes essential for transporting blood and nutrients for oxygen delivery and carbon dioxide removal. Much like how pipes can get rusty or clogged, disrupting ...
Go deeper with Google Headlines on:
[google_news title=”” keyword=”oxygen-delivering hydrogel” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
- PRISM MarketView Spotlights BioStem Technologies in the Expanding Wound Care Marketon February 26, 2024 at 7:39 am
Jason Matuszewski Jason Matuszewski, CEO of BioStem Technologies NEW YORK, Feb. 26, 2024 (GLOBE NEWSWIRE) -- PRISM MarketView announces the release of an insightful interview with BioStem Technologies ...
- TTUHSC to receive NIH grant to aid in biofilm dispersal research for chronic woundson February 26, 2024 at 5:54 am
The National Institute of Health has awarded TTUHSC nearly half a million dollars to help combat biofilm to treat chronic wounds better.
- ‘Care home, nurse practitioner breach Code for failures in wound management of woman’on February 25, 2024 at 3:59 pm
documentation of clinical discussions on wound management; escalation and referral processes for chronic wound management; and documentation of chronic wounds. She also recommended it consider making ...
- United States Advanced Wound Care Market Growth, Share, Trends, Demand And Forecast 2024-2032on February 23, 2024 at 11:49 pm
IMARC Group has published a market research report titled“ United States Advanced Wound Care Market Report by Product (Infection Managemen ...
- Lab-spun sponges form perfect scaffolds for growing skin cells to heal woundson February 23, 2024 at 7:41 am
A new technique for electrospinning sponges has allowed scientists from the University of Surrey to directly produce 3D scaffolds—on which skin grafts could be grown from the patient's own skin.
[google_news title=”” keyword=”chronic wounds” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]