
via Phys.org
Heart attack, or myocardial infarction, is one of the leading causes of death worldwide. Although modern surgical techniques, diagnostics and medications have greatly improved early survival from these events, many patients struggle with the long-term effects of permanently damaged tissue, and the 5-year mortality rate remains high.
Now, researchers reporting in ACS Nano have developed a minimally invasive exosome spray that helped repair rat hearts after myocardial infarction.
Scientists have explored using stem cell therapy as a way to regrow tissue after a heart attack. But introducing stem cells directly to the heart can be risky because they could trigger an immune response or grow uncontrollably, resulting in a tumor. Therefore, researchers have tried injecting exosomes –– membrane-bound sacs containing proteins, lipids and nucleic acids secreted by stem cells –– into the heart, but they often break down before they can have therapeutic effects. Others have developed cardiac patches, or scaffolds that help implanted exosomes last longer, but they usually must be placed on the heart during open-chest surgery. Yafeng Zhou and colleagues wanted to develop an exosome solution that could be sprayed onto the heart through a tiny incision, avoiding major surgery.
The researchers mixed exosomes from mesenchymal stem cells with fibrinogen, a protein involved in blood clotting. They added this solution to a tiny, double-barreled syringe that contained a separate solution of another clotting protein called thrombin. When the team sprayed the solutions out of the syringe onto a rat’s heart through a small chest incision, the liquids mixed and formed an exosome-containing gel that stuck to the heart. A mini-endoscope, inserted through a second small incision, guided the spray needle. In rats that had recently had a heart attack, the exosome spray lasted longer, healed injuries better and boosted the expression of beneficial proteins more than heart-injected exosomes. In pigs, the spray caused less severe immune reactions and surgical stress than open-chest surgery. The spray is a promising strategy to deliver therapeutic exosomes for heart repair, the researchers say.
Original Article: New spray could someday help heal damage after a heart attack
More from: American Chemical Society
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Exosome spray to repair hearts
- Spray-On Nanotherapeutic Restores Heart Function and Electrical Conductivity
Could a spritz of super-tiny gold and peptide particles on a damaged heart ... repair? State-of-the-art studies carried out by the University of Ottawa Faculty of Medicine Associate Professors Dr.
- Atomic Heart: How to Repair Mirror Mechanism
With this guide, solve all magnetic puzzles in A Glass, Darkly quest and repair the mirror mechanism ... up and the path to VDNH unlocks. Atomic Heart is available now for PlayStation, Xbox ...
- How To Fix The Wild Hearts Audio Bug
Wild Hearts might have received favorable reviews across all platforms but the PC port of the game has been heavily criticized for its poor performance and extremely buggy state. One such bug that ...
- Atomic Heart ‘Available in the Full Version of the Game’ – How To Fix
This may leave you wondering how to fix the Available in the Full Version of the Game in Atomic Heart. This issue typically occurs in Atomic Heart when playing through Game Pass. Fortunately ...
- Researchers developing a method to repair hearts
The regeneration and repair of cells that have been damaged in heart attacks could be possible in the future thanks to research at the University of Cincinnati. When a person suffers a heart attack, ...
Go deeper with Google Headlines on:
Exosome spray to repair hearts
[google_news title=”” keyword=”exosome spray to repair hearts” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
Heart attack treatment
- New studies look at heart disease disparities for Black, rural populations
Onwuyani also said that health insurance policy should move from models that focus on treatment, to ones that focus on prevention ... and unfavorable cardiovascular outcomes, such as heart attack and ...
- Heart failure: Exercise therapy is safe and helps improve recovery, study finds
Supervised exercise programs are safe and can help improve recovery and quality of life for people with heart failure, a study finds.
- Understanding the Signs of a Heart Attack in Women
Understanding the symptoms and risk factors associated with a heart attack is important to ensure you seek treatment quickly and can take steps to reduce and prevent your chances of having heart ...
- To Your Good Health: Risk of heart disease could be significantly lowered by statins
My husband’s doctor is repeatedly pushing statins on my husband. His cholesterol was high in the past and is still slightly high (239 mg/dL — borderline high).
- Risk of heart disease could be significantly lowered by statins
My husband’s doctor is repeatedly pushing statins on my husband. His cholesterol was high in the past and is still slightly high (239 mg/dL — borderline high). I’ve checked the heart risk calculator.
Go deeper with Google Headlines on:
Heart attack treatment
[google_news title=”” keyword=”heart attack treatment” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]