A fully printable biosensor made of soft bio-inks interfaces with a pig heart. Research about the biosensor, developed by researchers at Purdue University and Los Alamos National Laboratory, has been published in Nature Communications. (Photo Credit: Bongjoong Kim)
Surgeons may soon be able to localize critical regions in tissues and organs during a surgical operation thanks to a new, patent-pending Purdue University biosensor that can be printed in 3D using an automated printing system.
Chi Hwan Lee created the biosensor, which allows for simultaneous recording and imaging of tissues and organs during a surgical operation. Lee is the Leslie A. Geddes Assistant Professor of Biomedical Engineering in the Weldon School of Biomedical Engineering and assistant professor of mechanical engineering. Lee also has a courtesy appointment in materials engineering.
“Simultaneous recording and imaging could be useful during heart surgery in localizing critical regions and guiding surgical interventions such as a procedure for restoring normal heart rhythms,” Lee said.
Traditional methods to simultaneously record and image tissues and organs have proven difficult because other sensors used for recording typically interrupt the imaging process.
“To this end, we have developed an ultra-soft, thin and stretchable biosensor that is capable of seamlessly interfacing with the curvilinear surface of organs; for example the heart, even under large mechanical deformations, for example cardiac cycles,” Lee said. “This unique feature enables the simultaneous recording and imaging, which allows us to accurately indicate the origin of disease conditions: in this example, real-time observations on the propagation of myocardial infarction in 3D.”
By using soft bio-inks during the rapid prototyping of a custom-fit design, biosensors fit a variety of sizes and shapes of an organ. The bio-inks are softer than tissue, stretch without experiencing sensor degradation and have reliable natural adhesion to the wet surface of organs without needing additional adhesives. Kwan-Soo Lee’s research group in Los Alamos National Laboratory is responsible for the formulation and synthesis of the bio-inks.
A number of prototype biosensors using different shapes, sizes and configurations have been produced. Craig Goergen, the Leslie A. Geddes Associate Professor of Biomedical Engineering in Purdue’s Weldon School of Biomedical Engineering, and his laboratory group have tested the prototypes in mice and pigs in vivo.
“Professor Goergen and his team were successfully able to identify the exact location of myocardial infarctions over time using the prototype biosensors,” Lee said. “In addition to these tests, they also evaluated the biocompatibility and anti-biofouling properties of the biosensors, as well as the effects of the biosensors on cardiac function. They have shown no significant adverse effects.”
Research about the biosensor has been published in the peer-reviewed Nature Communications.
Original Article: Printable Purdue biosensor simultaneously records, makes images of tissues and organs
More from: Purdue University | Los Alamos National Laboratory
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
3D printed biosensor
- 3D Printing Material Market Expected to Grow at a CAGR of 23% from 2022-2029 | Exclusive Report By Exactitude Consultancy
Exactitude Consultancy, the market research and consulting wing of Ameliorate Digital Consultancy Private Limited has completed and published the ...
- Optimizing Wearable Medical Device Design with Advanced Silicone Adhesives
Technological advancements such as new wireless innovations, wearable biosensors, and 3D printing are keys to the expansion of this sector. Further, growth in wearable medical devices is being ...
- Researchers Discover a Biosensor Monitor to Track Pulse and Connect with Devices Wirelessly
Researchers at the University of California, Irvine have developed a novel self-powered, wristwatch-style health monitor that can wirelessly interact with a nearby smartphone or tablet and measure a ...
- Biomicrofluidics announces low-cost, 3D-printed microfluidic bioreactor as 2021 best paper award recipient
In the winning paper, "A low-cost 3D printed microfluidic bioreactor and ... drug screening and preclinical trials, fiber lasers, biosensors, and multiphoton microscopy. "We are working to model ...
- Low-cost portable device could perform onsite kidney disease testing
Developed by scientists at Australia's Flinders University, the gadget is a compact version of what's known as an aggregation induced emission biosensor ... within a 3D-printed body.
Go deeper with Google Headlines on:
3D printed biosensor
Go deeper with Bing News on:
Simultaneous recording and imaging biosensor
- PloS one
Are one's attachment avoidance toward a particular person and his/her placement of this particular person in the attachment hierarchy inversely overlapping? Four bifactor-analysis studies.
- Science news
Microrobotic agents can form swarms of targeted drug delivery for improved imaging analyses. In a new report now published in Science Advances, Junhui Law and a team of researchers in mechanical ...
- Tab32 Launches Plug-and-Play Cloud Imaging for Dentists and Dental Practices
Tab32 Launches Plug-and-Play Cloud Imaging for Dentists and Dental Practices. Platform-agnostic Image Cloud works with existing infrastructure to drive incredible value. ROCKLIN, ...
- Sensors (Basel, Switzerland)
Correction: Farina, G.L., et al. A Smartphone Application for Personal Assessments of Body Composition and Phenotyping. Sensors 2016, 16, 2163. Erratum: Sandeep P ...
- Laboratory of Applied Mechanobiology
Finally, our refined binding site suggests an allosteric relationship between PIP2 and F-actin binding that disfavors simultaneous interaction with both ligands, despite nonoverlapping binding sites.