Nasal sprays could be the future of treatment for Parkinson’s disease
Scientists at the University of York have made significant progress in the development of a nasal spray treatment for patients with Parkinson’s disease.
Researchers have developed a new gel that can adhere to tissue inside the nose alongside the drug levodopa, helping deliver treatment directly to the brain.
Levodopa is converted to dopamine in the brain, which makes-up for the deficit of dopamine-producing cells in Parkinson’s patients, and helps treat the symptoms of the disease. Over extended periods of time, however, levodopa becomes less effective, and increased doses are needed.
Professor David Smith, from the University of York’s Department of Chemistry, said: “The current drug used for Parkinson’s Disease is effective to a point, but after a long period of use the body starts to breakdown the drug before it gets to the brain where it is most needed.
“This means increased dosage is necessary, and in later stages, sometimes, instead of tablets, the drug has to be injected. Investigations into nasal sprays have long been of interest as a more effective delivery because of its direct route to the brain via the nerves that service the nose, but the challenge here is to find a way of making it adhere to the nasal tissue long enough to release a good dosage of the drug.”
The researchers created a gel, loaded with levodopa, that could flow into the nose as a liquid and then rapidly change to a thin layer of gel inside the nose. The method was tested in animal models by a team at King’s College London, where levodopa was successfully released from the gel into the blood and directly to the brain.
Professor Smith said: “The results indicated that the gel gave the drug better adhesion inside the nose, which allowed for better levels of uptake into both the blood and brain.”
The team are now working to incorporate these materials in nasal spray devices to progress to clinical trials in humans. The approach may also be relevant to other neurodegenerative diseases such as Alzheimer’s.
Khuloud Al-Jamal, Professor of Drug Delivery and Nanomedicine from King’s College London, said: “Not only did the gel perform better than a simple solution, but the brain uptake was better than that achieved using intravenous injection of the drug. This suggests that nasal delivery of Parkinson’s drugs using this type of gel may have clinical relevance.”
Original Article: Step-closer to nasal spray drug delivery for Parkinson’s disease
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Nasal spray drug delivery
- Europe Drug Delivery Market Report 2021: Market Size and Growth Projections to 2028on July 1, 2021 at 11:17 am
Drug delivery systems are designed advancements for the targeted shipping and managed launch of healing dealers.
- Altimmune ditches nasal COVID vaccine on weak trial dataon June 30, 2021 at 7:01 am
Just a few months after starting clinical trials of its nasal spray vaccine for COVID-19 ... making distribution and delivery easier. It had also hoped to demonstrate that nasal delivery would ...
- Nasal Drug Delivery Mode Market Size | Global Industry Trends, Demand, Growth and Business Opportunities in the coming yearson June 30, 2021 at 1:58 am
Spray, and Drop form. Among these, the 'Drop form' segment is likely to grow significantly in the Global Nasal Drug Delivery Mode Market during the forecast period due to its success rate and ...
- ViaNase electronic atomizers futurize nasal sprayon June 22, 2021 at 5:00 pm
You've probably started to think that all of the really great technological advancements in intranasal drug delivery had come and gone -- but Kurve Technology believes otherwise. The Bothell ...
- Ena Respiratory raises $24M to trial COVID-19 nasal sprayon June 22, 2021 at 3:47 pm
Ena Respiratory has raised up to $32 million Australian dollars ($24 million) to fund clinical development of a nasal spray designed to prevent COVID-19. The product, INNA-051, delivers a TLR2/6 ...
Go deeper with Google Headlines on:
Nasal spray drug delivery
Go deeper with Bing News on:
- Heart attack: Three meal staples could lead to heart diseaseon July 4, 2021 at 2:00 am
A HEART ATTACK is usually preceded by coronary artery disease - the most common type of heart disease, where the arteries that supply blood to the heart become clogged with plaque.
- Latest News in Parkinson Disease: Optimizing Multidisciplinary Care, Burden of Advanced Disease, and Moreon July 3, 2021 at 11:30 am
An overview of the latest news in Parkinson disease reported across MJH Life Sciences™. An overview of the latest news in Parkinson disease (PD) reported across MJH Life Sciences ™. Integrating ...
- Mark Richt Diagnosed With Parkinson's Disease | Patch PMon July 2, 2021 at 2:55 pm
"In the meantime I am going to enjoy the blessings I do have," former UGA coach Mark Richt tweeted of his Parkinson's diagnosis. A Brookhaven woman woke up to a large serval cat on her bed Wednesday ...
- Mark Richt Announces His Parkinson's Disease Diagnosison July 2, 2021 at 7:40 am
Former UGA head football coach Mark Richt announced Thursday night that he has been diagnosed with Parkinson's Disease ...
- Former Georgia coach Mark Richt announces he has Parkinson’s diseaseon July 1, 2021 at 8:59 pm
Former Georgia head coach Mark Richt announced, via Twitter, on Thursday that he has been diagnosed with Parkinson’s disease. The ACC Network analyst - and former Miami Hurricanes coach - last coached ...