via Harbin Institute of Technology
The research team of Professor He Qiang and Professor Wu Zhiguang from the Micro-Nano Technology Research Center of our school realized the active targeted treatment of glioma by swimming micro-nano robots for the first time, The research results were published online in the journal Science Robotics with the title “Dual-responsive biohybrid neutrobots for active target delivery”. Professor He Qiang and Professor Wu Zhiguang are the co-corresponding authors of the paper, and 2016 doctoral student Zhang Hongyue is the first author of the paper.
Glioblastoma (GBM) is one of the most difficult cancers to treat effectively. In the world, the number of cases and deaths in China is the highest. The important reason is the lack of precise therapy, and due to the existence of blood-brain barrier and blood-tumor barrier, the treatment approaches to intracranial tumor sites are limited. How to make drugs break through the blood-brain barrier, realize the active targeted delivery of drugs, and improve the curative effect of drugs on glioma has become a bottleneck problem in glioma medical field for a long time.
To solve this problem, the research team developed a swimming micro-nano robot based on immune cells in vivo, which was prepared by neutrophils phagocytosis of magnetic drug-loaded hydrogel wrapped in Escherichia coli membrane. The swimming micro-nano robot can effectively and stably carry anticancer drugs?such as paclitaxel. Relying on the self-developed control system, the swimming micro-nano robot is guided to the brain region, and the robot reaching the glioma region can autonomously sense the pathogen signal and swim to the patient site after crossing the blood-brain barrier, thus accurately releasing the drug to the patient, which is significantly improving the targeting efficiency of the drug. These research results establish that the swimming micro-nano robot based on immune cells is a potential precise therapy for glioma and can be used for systematic treatment of glioma.
Original Article: The micro-nano center has made important progress in the research of swimming micro-nano robot in the treatment of glioma
More from: Harbin Institute of Technology
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Swimming micro-nano robot
- STAR Market Daily: STAR 50 falls 0.53%, RMB 59.1 bln tradedon July 1, 2021 at 1:42 am
Shanghai Stock Exchange STAR 50 closed at 1,579.8 on Thursday. The STAR Market recorded a total trading volume of 1 bln shares with a turnover value of RMB 59.1 bln, up 7.3% from yesterday.
- Opening Keynote: Toshio Fukuda, IEEE Past President & Professor of Mechatronics Engineering at Meijo Universityon June 28, 2021 at 6:43 am
Toshio Fukuda is a professor of mechatronics engineering at Meijo University in Nagoya, Japan. He is also a professor at Waseda University and professor emeritus at Nagoya University. His research ...
- Discovery of ray sperms' unique swimming motion and demonstration with bio-inspired robot (w/video)on June 24, 2021 at 10:23 am
(Nanowerk News) It is generally agreed that sperms “swim” by beating or rotating their soft ... whose research focus is robotics as well as micro/nano manipulation and control. Environmental ...
- Microspheres quiver when shockedon June 24, 2021 at 1:30 am
Research on active colloids aims to create micro ... that swim through viscous fluids like primitive microorganisms. When these self-propelled particles come together, they can organize and move like ...
- NTU Singapore’s new mini robots can swim like jellyfish and build micro-deviceson June 16, 2021 at 2:55 am
Tiny robots with advanced dexterity and manoeuvrability could have applications in drug delivery and the construction of micro-structures ... robot capable of swimming in water and squeezing ...
Go deeper with Google Headlines on:
Swimming micro-nano robot
Go deeper with Bing News on:
Glioblastoma
- Kintara Reports Positive Phase 2 Trial On Recurrent Glioblastoma Multiforme; Stock Surgeson July 1, 2021 at 5:36 am
Kintara Therapeutics Inc. (KTRA) revealed a promising results from phase 2 clinical trial of VAL-083 for recurrent glioblastoma ...
- Kintara Therapeutics Sees Positive Results for Glioblastoma Multiforme Treatmenton July 1, 2021 at 5:23 am
The biopharmaceutical company said the Phase 2 trial is a two-arm, biomarker-driven study testing VAL-083 in glioblastoma multiforme patients who have an unmethylated promoter of the methylguanine DNA ...
- Despite dark diagnosis, Campbellsport teen remains ray of light amid battle against stage 4 glioblastomaon July 1, 2021 at 4:01 am
FOND DU LAC - Alexis Feucht, a 17-year-old from Campbellsport, is battling a brutal stage four glioblastoma. The high school graduate was dealt some unfortunate cards. Even after she was diagnosed, ...
- Blood stem cells are linked to the progression of aggressive brain tumourson June 30, 2021 at 5:58 am
Using transcriptome analysis and gene expression sequencing, researchers have discovered that blood stem cells (HSPCs) cause increased cell division in glioblastoma tumours and suppress the immune ...
- Global Glioblastoma Multiforme (GBM) Treatment Market Could Reach Nearly $1.8 Billion By 2027on June 29, 2021 at 8:27 am
June 29, 2021 /PRNewswire via COMTEX/ -- PALM BEACH, Fla., June 29, 2021 /PRNewswire/ -- Glioblastoma multiforme (GBM) is one of the areas where the research & development investments are high ...
Go deeper with Google Headlines on:
Glioblastoma
