via Duke University Pratt School of Engineering
A Duke-led team of scientists has developed a bio-compatible surgical patch that releases non-opioid painkillers directly to the site of a wound for days and then dissolves away.
The polymer patch provides a controlled release of a drug that blocks the enzyme COX-2 (cyclooxygenase-2,) which drives pain and inflammation. The study appears Jan. 10, 2021 in the Journal of Controlled Release.
When they started “We were making hernia meshes and different antimicrobial films,” said Matthew Becker, the Hugo L. Blomquist professor chemistry at Duke, and last author on the paper. “We thought you could potentially put pain drugs or anesthetics in the film if you just sew it in as you’re stitching the person up, then you wouldn’t necessarily have to prescribe any opioids,” Becker said.
The work grew out of a $2 million grant Becker received from the state of Ohio at his previous institution to investigate non-opioid pain management , one measure toward fighting a nationwide epidemic of opioid drug abuse. Since arriving at Duke in 2019, Becker’s team has partnered with Duke pain control expert Dr. Ru-Rong Ji and his team to refine the idea.
The polymer itself, comprised of poly(ester urea) homopolymers and co-polymers, is also special, said Becker, who is also a professor of mechanical engineering and materials science in Duke’s Pratt School of Engineering.
“Most polymers that are used in medicine swell, and everything comes out at once,” Becker said. But this polymer erodes slowly, and its painkiller dose and longevity can be controlled simply by varying the surface area and thicknesses. “The film is about like a piece of paper.”
“If you can get four or five days of pain control out of the patch and not have to take those other pain drugs, not only do you avoid some of the side effects and risks of addiction, you’re concentrating therapy where you need it,” Becker said.
Rat studies also showed that the painkiller stayed in tissues close to the patch site, rather than dissolving into circulating plasma.
Becker said the patch should be able to provide three or four days of wound-pain management, which is the critical period for post-surgical pain. The implantable film would be particularly useful in endoscopic procedures and instances where the physicians and patients would like to avoid opioid exposure such as Cesarean births and pediatric surgeries. In studies with mice that mimic the neuropathic pain of diabetes, the pain patch was placed against a nerve and provided a four-day nerve block.
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Bio-compatible surgical patch
- Biomaterials that improve lifeon February 11, 2021 at 7:50 pm
Dental and orthopaedic implants, vascular grafts and skin patches are the most well-known materials in ... First dental implants with new biocompatible coating certified in Poland market in 2020 and ...
- Novel Device Treats Damaged Nerves, then Dissolveson February 11, 2021 at 4:00 pm
One of the Holy Grail inventions of medical devices is one that is bio-compatible, serves a therapeutic function ... of electricity to damaged peripheral nerves in rats after a surgical repair process ...
- New Glue May Soon Replace Sutures – Even in a Beating Hearton February 10, 2021 at 4:00 pm
A new surgical adhesive is strong and flexible enough, and biocompatible enough, to be used to help patch heart defects, doing away with the need for sutures or stables. Developed by researchers at ...
- Tapes and Drapes: Adhesives and Materials in Surgical Supplieson February 10, 2021 at 4:00 pm
Transdermal patches are used to deliver a time-release ... and woven and nonwoven biocompatible pressure-sensitive adhesive tapes in addition to surgical drapes and ostomy components. A converter can ...
- A light-reflecting balloon catheter for atraumatic tissue defect repairon February 5, 2021 at 4:00 pm
3 Department of Cardiac Surgery, Boston Children’s Hospital ... catheter with a reflective surface coating that could be used to adhere biodegradable patches to tissues. The device unfolds the patch ...
Go deeper with Google Headlines on:
Bio-compatible surgical patch
Go deeper with Bing News on:
- Children of Regis aged care facility residents who died speak out about 'culture of neglect'on February 18, 2021 at 1:32 pm
Yvonne's father Henk Niemen died after a wound on his foot remained unseen by staff for five days at a Perth aged care facility. His daughter and the child of another deceased resident have serious ...
- Smith+Nephew sees further pandemic pain as annual profit slumpson February 18, 2021 at 4:44 am
Smith+Nephew warned on Thursday the impact of the COVID-19 pandemic is likely to continue into the first half of 2021 and that it was uncertain on the timing of recovery, as the medical products maker ...
- Global Wound Care Market Size is Expected to Reach Around US$ 28.20 Billion by 2030 | CAGR 4.5%on February 17, 2021 at 10:21 pm
The global Wound Care market size is expected to be worth around US$ 28.20 billion by 2030, according to a new report by Vision Research Reports. The Research Report Titled Wound Care Market Size, ...
- SANUWAVE Health Deserves Investors Attention, And its Best-In-Class Diabetic Wound Care Treatment Is Only The First Reason Whyon February 16, 2021 at 4:45 am
Even among the unprecedented challenges experienced throughout 2020, SANUWAVE Health (OTCCQB: SNWV) enjoyed a transformative year with credit going to its skilled management ...
- Wound Care Market Size, Share & Trends Analysis Report By Application, By Product, By End Use, By Region And Segment Forecasts, 2021 - 2028on February 16, 2021 at 4:08 am
Reportlinker.com announces the release of the report "Wound Care Market Size, Share & Trends Analysis Report By ...