
X-ray of a healthy thigh bone and one that was treated and healed with the new method
Researchers at Lund University in Sweden, in collaboration with colleagues in Dresden, Germany, have developed a way of combining a bone substitute and drugs to regenerate bone and heal severe fractures in the thigh or shin bone.
The study, published in the research journal Science Advances, was conducted on rats, but the researchers think that the method in various combinations will soon be commonplace in clinical settings.
“The drugs and materials we used in the study for the regeneration of bone are already approved. We simply packaged them in a new combination. Therefore, there are no real obstacles to already using the method in clinical studies for certain major bone defects that are difficult to resolve in patients. But we want to introduce the technique in a controlled form via clinical studies and have recently been granted ethical approval”, says Deepak Raina, orthopaedics researcher and the lead author of the study.
Bones in the human body have a fantastic ability to repair injury, but some defects are so large or complicated that the healing process is delayed or absent. This may be due to the bone having been subjected to a major trauma in connection with a traffic accident for example, or a tumour or infection causing a major bone defect. These cases are currently treated through bone transplantation, usually with bone taken from the patient’s own pelvis.
“In cases involving severe open fractures in the lower leg, over 5 per cent of all fractures fail to heal. With our method, we will be able to avoid taking bone from the pelvis, which is a major gain for the patient.”
There is a need for new solutions and several research teams, both in Europe and in the USA, are working on improving the bone healing process. So far, the injectable cocktail successfully mixed by the Swedish and German researchers consists of three different components: an artificial ceramic material developed in Lund, a bioactive bone protein (rhBMP-2) and a drug, bisphosphonate, that combats bone resorption.
“The bone protein we use has had negative effects in previous studies due to a secondary premature bone resorption, among other things. We have successfully mitigated this effect with the bisphosphonate and, by packaging the drug in a slowly resorbing bone substitute, we can control the speed of release. In the current study with the combination, we achieved a six-fold reduction in the amount of protein compared to previous efforts, while still inducing bone formation. The result was that even fractures with an extensive bone defect could heal without complications. We believe this finding will be of great clinical use in the future”, says Deepak Raina.
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Synthetic bone
- Dental Bone Grafts & Substitutes Market to Exhibit a Decent CAGR of 9.4% and Hit USD 1.02 Billion by 2028on March 2, 2021 at 9:41 pm
The global Dental Bone Grafts & Substitutes market size was valued at US$ 516.7 million in 2020 and is anticipated to grow at a CAGR of 9.4% during forecast period 2021 to 2028. The global Dental Bone ...
- The Story Behind New Hermes Men's Fragrance H24on March 2, 2021 at 6:41 am
With so many iconic mainstays in the heritage brand’s scent stable—think Terre D’Hermès, Eau D’Orange Vert, Voyage D’ Hermès —the bar has been set improbably high, and yet H24, the new introduction, ...
- Kuros Biosciences Announces MagnetOs Sales and Distribution Agreements Across Northern Europeon March 1, 2021 at 10:08 pm
Agreements in Netherlands, Switzerland and Austria and letter of intent in FinlandSupports further acceleration of sales of MagnetOs bone graft ...
- Entera Bio Announces Publication of Phase 2 Hypoparathyroidism Study in the Journal of Bone and ...on February 26, 2021 at 12:35 am
Entera Bio Ltd. (NASDAQ: ENTX), a leader in the development of orally delivered large molecule therapeutics, announced today the publication of the results of its previously completed Phase 2a study ...
- Could Fruit Flies Help Match Patients With Cancer Treatments?on February 25, 2021 at 11:00 pm
A British company is seeding genetically modified flies with human tumors, giving patients their own personal drug trials.
Go deeper with Google Headlines on:
Synthetic bone
Go deeper with Bing News on:
Bone regeneration
- Orthocell’s CelGro® Dental granted inclusion on Australian Prostheses Liston March 2, 2021 at 11:01 pm
The prostheses list defines the minimum value of benefit private insurers pay for CelGro® Dental used in approved dental bone and soft tissue ...
- Could An Emerging Soft Tissue Regeneration System Have An Impact On Foot And Ankle Care?on March 1, 2021 at 11:36 am
Over 20 years in practice, I have spent a great deal of time looking for a modality that could treat the majority of foot and ankle ailments we see in our practices. When I was in residency, almost ...
- Repair of segmental bone defect using tissue engineered heterogeneous deproteinized bone doped with lithiumon March 1, 2021 at 9:17 am
Lithium have been shown to play an important role in improving the osteogenic properties of biomaterials. This study aims to explore the osteogenic improvement effect of tissue engineered ...
- Professor suggests how to calculate implant materials' permeabilityon March 1, 2021 at 9:07 am
An associate professor from RUDN University found out the effect of the number and size of pores on the permeability of bone implants by biological fluids. The results of the study could help choose ...
- RUDN University professor suggested how to calculate the implant materials permeabilityon March 1, 2021 at 6:14 am
An associate professor from RUDN University found out the effect of the number and size of pores on the permeability of bone implants by biological fluids. The results of the study could help choose ...