via Carnegie Mellon University
Carnegie Mellon University researchers reveal fastest known COVID-19 antibody test with high sensitivity due to a unique, 3D printing technology and an electrochemical reaction.
Researchers at Carnegie Mellon University, in collaboration with the University of Pittsburgh and UPMC, have developed one of the fastest known COVID-19 antibody tests. The test results are available in 10 to 15 seconds and detect the presence of two of the antibodies to SARS-CoV-2, the virus responsible for COVID-19. Such a quick and effective test could be a game-changer for controlling the spread of the pandemic.
The breakthrough test would require a very small drop of blood from a fingertip (less than five microliters) to identify two antibodies of the virus: spike S1 protein and receptor binding domain (RBD). It can detect antibody concentrations at an extremely low level, one picomolar (0.15 nanograms per milliliter), through an electrochemical reaction within a handheld microfluidic device. Results are sent almost immediately to a simple interface on a smart phone. The device can be cleaned (i.e. regenerated) within one minute using a special chemistry discovered by the researchers that allows multiple, successive readings from the same device.
A simple yet elegant additive manufacturing technology called aerosol jet 3D printing is responsible for the efficiency and accuracy of this testing device. Tiny, inexpensive gold micropillar electrodes are printed at nanoscale using aerosol droplets that are thermally sintered together. This causes a rough, irregular surface that provides increased surface area of the micropillars and an enhanced electrochemical reaction, where antibodies can latch on to antigens coated on the electrode. The specific geometry allows the micropillars to load more proteins for detection, resulting in very accurate, quick results.
“This sensing platform can also be used to detect other infectious diseases, potentially affecting the course of pandemics.”
RAHUL PANAT, ASSOCIATE PROFESSOR, DEPARTMENT OF MECHANICAL ENGINEERING
The test has a very low error rate since the binding reaction between the antibody and antigen used in the device is highly selective. This natural design was exploited by the researchers to their advantage.
The device, which has a provisional patent, is inexpensive to make (in the tens of dollars). And, the manufacturing capabilities already exist.
“My research team was working on 3D printed high-performance sensors to detect dopamine, a chemical in brain, when we realized that we could adapt our work for COVID-19 testing,” said?Rahul Panat, an associate professor of mechanical engineering at Carnegie Mellon who uses specialized additive manufacturing techniques for research ranging from brain-computer interfaces to biomonitoring devices. “We shifted our research to apply our expertise to combatting this devastating pandemic.”
Knowing the work would require a multidisciplinary approach, Panat collaborated with Shou-Jiang Gao, leader of the Cancer Virology Program at UPMC Hillman Cancer Center and professor of microbiology and molecular genetics at the University of Pittsburgh. Azahar Ali, a postdoctoral researcher in Panat’s Advanced Manufacturing and Materials Lab, was the lead author of the study. Their research findings are available on MedRxiv in anticipation of peer review.
“We’re sharing these results at the time of preprint and prior to peer review because of the significant, potential impact on public health,” said Panat.
This sensing platform can also be used for the detection of other infectious diseases.
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
COVID-19 Antibody Test
- Elasmogen announces a panel of novel, potent, anti-COVID-19 therapeutic candidates identified through collaboration with U.S. research partnerson January 24, 2021 at 4:13 pm
Elasmogen Ltd, the pioneering biopharmaceutical company leading the development of VNAR and soloMER ™ biologics, today announces a significant breakthrough in the identification of next-generation ...
- Covid-19: Bangladesh finally approves antibody teston January 24, 2021 at 1:51 pm
Earlier, Bangladesh Medical Research Council (BMRC) permitted icddr,b to carry out efficiency verification test for antibody tests ...
- Antibody test for Covid-19 gets govt nodon January 24, 2021 at 11:12 am
"There has long been a demand for the approval of antibody tests. We have now approved it, effective from today," he told reporters at his secretariat office. The antibody tests can detect if a person ...
- Govt has approved rapid antibody test for Covid-19: health ministeron January 24, 2021 at 4:33 am
The minister said, "There has been demand for the approval of antibody test for long. Now we have approved it." The antibody test looks for past presence of the virus and a possible immune response to ...
- Hy-Vee to Offer COVID-19 Rapid Antibody Testingon January 22, 2021 at 12:05 am
Hy-Vee, Inc. will begin offering COVID-19 rapid antibody testing at more than 250 Hy-Vee pharmacy locations on Monday, Jan. 18. Patients will receive same day test results in as few as 15 minutes ...
Go deeper with Google Headlines on:
COVID-19 Antibody Test
Go deeper with Bing News on:
- 38 Capitol Police officers test positive for Covid-19 after Capitol rioton January 24, 2021 at 3:18 pm
More than three dozen Capitol Police officers have tested positive for coronavirus since the Capitol riot on January 6, the union representing the Capitol Police told CNN Sunday.
- Covid-19 Bill Negotiations Offer First Test of Biden’s Bipartisanship Renewal Efforton January 24, 2021 at 12:02 pm
Brian Deese, head of the White House’s National Economic Council, is meeting Sunday with a group of lawmakers previously involved in bipartisan negotiations to discuss the president coronavirus-relief ...
- Biden’s first big foreign policy test will be fixing the COVID-19 vaccine messon January 24, 2021 at 12:01 pm
The most immediate foreign policy message Biden can send to convince allies America is back does not involve Iran or China or Russia. Rather, it requires the president to succeed in rallying ...
- Fauci says UK COVID-19 strain could 'cause more damage,' US will test for vaccine efficacyon January 24, 2021 at 11:31 am
Dr. Anthony Fauci said on Sunday that the U.K. variant strain of coronavirus does appear to be more deadly, but what this means for vaccine efficacy is still unknown.
- COVID-19 test results come in minutes instead days at Tacoma assisted living facilityon January 24, 2021 at 9:15 am
A Tacoma assisted living community implemented a new rapid testing system recently that detects cases of COVID-19 in minutes instead of days. GenCare Lifestyle at Point Ruston is using a third-party ...