via University of Melbourne
World-first techniques for predicting breast cancer risk from mammograms that were developed in Melbourne could revolutionise breast screening by allowing it to be tailored to women at minimal extra cost.
Published in the International Journal of Cancer, the University of Melbourne-led study found two new mammogram-based measures of risk. When these measures are combined, they are more effective in stratifying women in terms of their risk of breast cancer than breast density and all the known genetic risk factors.
Researchers say if successfully adopted, their new measures could substantially improve screening, make it more effective in reducing mortality and less stressful for women, and therefore encourage more to be screened. They could also help address the problem of dense breasts.
Since the late 1970s, scientists have known that women with denser breasts, which shows up on a mammogram as having more white or bright regions, are more likely to be diagnosed with breast cancer and to have it missed at screening.
Collaborating with Cancer Council Victoria and BreastScreen Victoria, University of Melbourne researchers were the first to study other ways of investigating breast cancer risk using mammograms.
Using computer programs to analyse mammogram images of large numbers of women with and without breast cancer, they found two new measures for extracting risk information. Cirrocumulus is based on the image’s brightest areas and Cirrus on its texture.
First, they used a semi-automated computer method to measure density at the usual, and successively higher levels of brightness to create Cirrocumulus. They then used artificial intelligence (AI) and high-speed computing to learn about new aspects of the texture (not brightness) of a mammogram that predict breast cancer risk and created Cirrus.
When their new Cirrocumulus and Cirrus measures were combined, they substantially improved risk prediction beyond that of all other known risk factors.
Lead researcher and University of Melbourne Professor John Hopper said that in terms of understanding how much women differ in their risks of breast cancer, these developments could be the most significant since the breast cancer genes BRCA1 and BRCA2 were discovered 25 years ago.
“These measures could revolutionise mammographic screening at little extra cost, as they simply use computer programs,” Professor Hopper said.
“The new measures could also be combined with other risk factors collected at screening, such as family history and lifestyle factors, to provide an even stronger and holistic picture of a woman’s risk.
“Tailored screening – not ‘one size fits all’ – could then be based on accurately identifying women at high, as well as low, risk so that their screening can be personalised.
“Given mammography is now digital, and our measures are now computerised, women could be assessed for their risk at the time of screening – automatically – and given recommendations for their future screening based on their personal risk, not just their age.”
Professor Hopper said this information could be used to ease pressure on BreastScreen, which had to close for a period during the COVID-19 pandemic and is looking for ways to best handle the backlog while continuing to provide a valuable service with limited resources.
He said the current breakthrough could not have occurred without the extraordinary support his mammogram research had received from the National Breast Cancer Foundation, starting with its first funding round more than 20 years ago.
“Only around 55 per cent of Australian women aged 50-74 currently present for screening aimed at detecting breast cancers early,” he said.
“Knowing that screening could also give an accurate risk prediction could encourage more women to take up the offer of free screening. Women with high risk based on their mammogram would also benefit greatly from also knowing their genetic risk.”
Adjunct Associate Professor Helen Frazer, Clinical Director of St Vincent’s BreastScreen Melbourne, said that improvements in assessing a woman’s risk of breast cancer would be transformative for screening programs.
“Using AI developments to assess risk and personalise screening could deliver significant gains in the fight against breast cancer,” Adjunct Associate Professor Frazer said.
The study involved participants in the Melbourne Collaborative Cohort Study run by Cancer Council Victoria, and the Australian Breast Cancer Family Study and Twins Research Australia run from the University of Melbourne.
Participating women filled out a questionnaire and allowed researchers to access their mammograms from BreastScreen, with other providers or their own copies.
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Breast cancer screening
- Mario Lopez, the American Cancer Society and the National Football League Will Send A Lucky Fan to Super Bowl LVon January 25, 2021 at 9:07 am
The American Cancer Society (ACS), through its Crucial Catch partnership with the National Football League (NFL), announced today that two-time Emmy winner and host of NBC's "Access Hollywood", Mario ...
- CSC Executive Chair Joins First Lady Dr. Jill Biden to Focus on Screening and Navigation for Cancer Patientson January 22, 2021 at 1:56 pm
WASHINGTON, D.C., Jan. (GLOBE NEWSWIRE) -- As seen on ABC News and other major media outlets, Kim Thiboldeaux, Executive Chair of the Cancer Support Community ...
- New studies clarify which genes may raise the risk of breast canceron January 21, 2021 at 12:18 pm
Two large studies give a much sharper picture of which inherited mutations raise the risk of breast cancer for women without a family history of the disease, and how common these flawed genes are ...
- Large Studies ID Other Genes Linked To Breast Canceron January 21, 2021 at 11:09 am
The research enables doctors to advise patients about risks associated with a half dozen genes in addition to BRCA1 and BRCA2. News about cancer also focuses on covid, gene-controlling circadian ...
- Broader Genetic Testing May Improve Breast Cancer Risk Assessmenton January 21, 2021 at 10:24 am
Conducting hereditary cancer genetic testing in the general population could enhance breast cancer risk assessment in women.
Go deeper with Google Headlines on:
Breast cancer screening
Go deeper with Bing News on:
- Alula Raises $2.2M for its Digital Platform for Cancer Patients and Their Caregiverson January 25, 2021 at 9:31 am
Bier, a cancer survivor, founded Alula, a digital platform for cancer patients and their caregivers to manage the experience of cancer.
- Big Data Tool Finds Variations in Treatment and Costs Across 3 Cancer Typeson January 25, 2021 at 9:21 am
Using real-world data from more than 4000 patients with common cancers, an algorithm was able to detect variations in care that, if reduced, could result in a median savings of $26,773 per patient.
- Rugo Sets the Stage for a Busy Year in Breast Canceron January 25, 2021 at 8:10 am
Hope S. Rugo, MD, FASCO, describes her work in medical oncology, previews the upcoming Miami Breast Cancer Conference, and speaks to what she is looking forward to in 2021 with regard to breast cancer ...
- UToledo researchers receive $1.4 million to study breast cancer treatmenton January 25, 2021 at 7:56 am
Researchers at The University of Toledo have received a three-year funding award of $1.4 million from the U.S. Department of Defense for a pre-clinical study of promising new chemotherapy aimed at ...
- UT research on treatment of triple-negative breast cancer receives $1.4 million funding awardon January 25, 2021 at 7:42 am
TOLEDO, Ohio (WTVG) - The U.S. Department of Defense has awarded the University of Toledo with a three-year funding award of $1.4 million for a pre-clinical study of promising new chemotherapy aimed ...