A highly elastic hybrid construct for fibrocartilaginous regeneration is produced by coprinting a cell-laden gellan gum/fibrinogen composite bioink together with a silk fibroin methacrylate bioink in an interleaved crosshatch pattern.
Wake Forest Institute for Regenerative Medicine scientists (WFIRM) have developed a method to bioprint a type of cartilage that could someday help restore knee function damaged by arthritis or injury.
This cartilage, known as fibrocartilage, helps connect tendons or ligaments or bones and is primarily found in the meniscus in the knee. The meniscus is the tough, rubbery cartilage that acts as a shock absorber in the knee joint. Degeneration of the meniscus tissue affects millions of patients and arthroscopic partial meniscectomy is one of the most common orthopedic operations performed. Besides surgery, there is a lack of available treatment options.
In this latest proof-of-concept strategy, the scientists have been able to 3D bioprint a hybrid tissue construct for cartilage regeneration by printing two specialized bioinks – hydrogels that contain the cells – together to create a new formulation that provides a cell-friendly microenvironment and structural integrity. This work is done with the Integrated Tissue and Organ Printing System, a 3D bioprinter that was developed by WFIRM researchers over a 14-year period. The system deposits both biodegradable, plastic-like materials to form the tissue “shape” and bioinks that contain the cells to build new tissues and organs.
“In this study, we have been able to produce a highly elastic hybrid construct for advanced fibrocartilaginous regeneration,” said Sang Jin Lee, Ph.D, associate professor at WFIRM and author of the paper recently published by Chemistry of Materials journal. “The results demonstrate that this bioprinted construct offers a versatile and promising alternative for the production of this type of tissue.”
For the study, Lee and the WFIRM research team tested various formulations and measured response to applied forces or stresses, the swelling ratio and the material strength and flexibility. One provided the proper cellular microenvironment to maintain the cells and helping them grow while the other bioink offered excellent biomechanical behavior and structural integrity. The final formula of the two bioinks used were co-printed layer by layer to create a mesh-like pattern. The constructs were implanted into a small animal model for observation for 10 weeks and evaluated at intermittent time periods, showing proper function.
“A larger preclinical study will be needed to further examine the body’s response and the functional recovery of the joint with use of this regenerative medicine treatment,” said James Yoo, MD, PhD, professor at WFIRM.
“We have such a need for effective treatments and therapies to help patients deal with degenerative joint problems, especially the knee,” said Anthony Atala, MD, director of WFIRM. “This proof-of-concept study helps point our work in the right direction to someday be able to engineer this crucial tissue that is so important for patients.”
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Revotek Deploys Its Bioink Technology to Research Instituteson April 29, 2021 at 6:30 am
Revotek Co., Ltd. ("Revotek"), a vertically integrated biotech company specialized in 3D bioprinting, and West China Hospital ...
- Allegro 3D Awarded $997,692 from the National Science Foundationon April 28, 2021 at 6:37 pm
Small Business Innovation Research Program Provides Seed Funding for R & D SAN DIEGO, CA, UNITED STATES, April 27, 2021 /EINPresswire.com / -- Allegro 3D , Inc. has been awarded a National Science ...
- Combo 3D bioprinting patches up skin and bone injuries in one procedureon April 26, 2021 at 7:38 pm
Researchers at Pennsylvania State University have developed a method to patch up injuries by 3D printing both hard and soft tissues at the same time, using two different “bioinks.” In tests on rats, ...
- 3D Bioprinting Market Size, Share, Competition Landscape, Manufacturers Analysis and Future Opportunity Outlook 2030 | Says FMI Analyston April 26, 2021 at 11:17 am
A recent market study published by Future Market Insights (FMI) on the 3D bioprinting market offers global industry analysis for 2015-2019 & opportunity assessment for 2020-2030. The report consists ...
- Skin 3D Bioprinting Market Size & Analysis-Forecast to 2026on April 22, 2021 at 8:05 am
Brooklyn, New York, April 22, 2021 (GLOBE NEWSWIRE) -- According to a new market research report published by Global Market Estimates, the Skin 3D Bioprinting Market will grow with a high CAGR ...
Go deeper with Google Headlines on:
Go deeper with Bing News on:
Integrated Tissue and Organ Printing System
- AI in 3D Bioprintingon April 30, 2021 at 3:01 am
Without question, research on 3D bioprinting is new, disruptive, and expanding too. By taking advantage of AI, 3D bio-printing technology can only get better.
- Tiny brains grown in 3D-printed bioreactoron April 6, 2021 at 8:02 am
2021 -- Scientists from MIT and the Indian Institute of Technology Madras have grown small amounts of self-organizing brain tissue, known as organoids, in a tiny 3D-printed system that allows ...
- 3D Printing in Healthcare Market Analysis and Forecast by Key Players, Share, Trend, Segmentation to 2026on April 5, 2021 at 3:40 am
Moreover, growing demand for organ ... of 3D printing in healthcare across the world. However, lack availability of skilled professional, high cost associated with 3D printing system in healthcare ...
- Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactionson April 4, 2021 at 5:01 pm
7 Delft Center for Systems and Control ... throughout a whole organ or animal (9). To successfully harness the power of MALDI IMS and LA-ICP-MS for molecular analysis of diseased tissues, the ...
- 3D-Bioprinted Cell Therapy and Disease Modeling Applicationson April 2, 2021 at 4:09 am
To draw from the rich palette of materials, the bioprinter’s microfluidic printhead employs an integrated valving system that ... necessarily creating organs and tissues that look identical ...