Lauren Cohee, MD
Intervention May Be Key to Controlling Malaria in Africa and Other Tropical Countries, UM School of Medicine Researchers Find
With nearly half of the world’s population at risk for life-threatening malaria infections, University of Maryland School of Medicine researchers and their colleagues identified an important public health measure to control the disease. Use of preventive antimalarial treatments reduces by half the number of malaria infections among schoolchildren, according to a new analysis published today in The Lancet Global Health. Preventive treatment also reduces cases of anemia among schoolchildren by 15 percent and is associated with improved learning in children older than 10 years.
The study was the first meta-analysis of its kind and included 15,000 schoolchildren across seven African countries. It was conducted by an international consortium of 33 researchers from 15 institutions.
An estimated 3.4 billion people worldwide are at risk of contracting malaria, and 400,000 die from the disease every year, according to the World Health Organization (WHO). While the WHO recommends providing intermittent preventive treatment to pregnant women, infants and young children in some malaria-endemic areas, they have not issued recommendations for school-age children despite growing evidence that use of these preventive mediations works to prevent infections and improve health.
Malaria is transmitted by mosquitos infected with a parasite and remains prevalent in Africa, Central and South America, and Southeast Asia. Malaria can cause fevers, headache and chills, as well as anemia due to the parasite’s destruction of red blood cells. Anemia can cause severe fatigue, headaches, delayed development and poor performance in school. Malaria can also lead to organ failure and can be fatal if left untreated.
“We have overlooked the burden of malaria in school-age children. The resulting chronic illness and anemia can impair development and lead to cognitive problems making it tougher to pay attention or learn in school,” says lead author Lauren Cohee, MD, an Instructor of Pediatrics and faculty member in the Malaria Research Program in the Center for Vaccine Development and Global Health at the University of Maryland School of Medicine. “Children may also play an important role in disease transmission and by treating their infections, we may have substantial public health consequences on the surrounding populations.”
In the journal article, Dr. Cohee and her colleagues pointed out that public health campaigns to provide antimalarial medications to school-aged children may be a way to improve the health and wellness of children, but to curb the disease spread in communities where malaria is endemic.
For their current study, the school-age malaria study group combined data on 15,658 research participants from 11 different clinical studies that tested malaria preventative medications in children ages 5 to 15 years. The children were from seven different countries in sub-Saharan Africa; 8,437 children were given malaria preventives, and 7,221 participants were either not treated or were given a placebo as a control.
Doses of preventive drugs were given as often as once a month or as infrequently as once a year depending on the study. The children were monitored for an average of 43-weeks. Six of the clinical trials evaluated cognitive function between children who received the malaria preventives and those who did not.
Preventive malaria drugs can cause side effects such as nausea, vomiting, upset stomach, headache or weakness, and all 11 studies did report instances of these symptoms. No serious side effects, however, were reported in any of the studies.
Dr. Cohee noted that preventive treatment of malaria could be added to existing school-based health programs, including nutrition and deworming, to further promote the overall health of the learner. “Utilizing schools as a platform to deliver preventive treatment improves the feasibility of this intervention and builds upon the ever increasing rates of primary school enrollment across the malaria endemic world,” Dr. Cohee said.
“More than 200 million children in Africa alone are at risk of becoming infected with malaria and in some regions more than 50 percent of them will ultimately contract it,” says E. Albert Reece, MD, PhD, MBA, Executive Vice President for Medical Affairs, University of Maryland Baltimore, and the John Z. and Akiko K. Bowers Distinguished Professor and Dean, University of Maryland School of Medicine. “We must continue to promote research-based interventions that will improve the health and wellness of our world’s children.”
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Preventive antimalarial treatments
- Posts falsely claim Chinese official touted antibiotic oxytetracycline as Covid-19 treatmenton April 12, 2021 at 2:15 am
Facebook, Twitter and Weibo posts purport to show a Chinese official promoting antimalarial drug chloroquine phosphate, which they claim is also known as oxytetracycline, as a Covid-19 treatment at ..
- Central Nervous System Therapeutics Market to grow at a Significant Rate During the Forecast Period | TechSci Researchon April 6, 2021 at 4:58 am
Demand for effective therapeutics for treatment of CNS is a driving factor for the growth of Global Central Nervous System Therapeutics Market in forecast period. According to TechSci Research ...
- Bleeding Disorders Drugs Market to Grow at a CAGR of 8.44% during the Forecast Period | TechSci Researchon April 6, 2021 at 1:32 am
Plasmodium Knowlesi), By Application (Prevention, Treatment of Malaria), By Distribution Channel (Hospital Pharmacy, Retail Pharmacy, E-Commerce, Others), By Region, Forecast & Opportunities, 2025 ...
- Q&A: Revenue Code Assignment for COVID-19 Monoclonal Antibodieson April 5, 2021 at 10:12 am
Administration is billed under revenue code 0771, which is for Vaccine Administration under the Preventative Care Services category, even though this drug or combination of drugs is not ...
- The ‘last mile’ of malaria elimination in Cambodiaon April 1, 2021 at 11:01 pm
Since the 2000s, Cambodia has been at the epicentre of resistance to multiple antimalarial medicines ... to identify and target potential transmitters by providing preventive anti-malarial medication ...
Go deeper with Google Headlines on:
Preventive antimalarial treatments
Go deeper with Bing News on:
- Clinical trial brings an effective HIV vaccine a step closeron April 12, 2021 at 8:17 am
A phase 1 clinical trial confirms that the first stage of a novel approach to HIV vaccination is safe and, in principle, very effective.
- Force of infection: a determinant of vaccine efficacy?on April 12, 2021 at 4:21 am
Vaccine efficacy (VE) can vary in different settings. Of the many proposed setting-dependent determinants of VE, force of infection (FoI) stands out as one of the most direct, proximate, and ...
- Purdue researchers use malaria expertise to track COVID-19 in Indianaon April 8, 2021 at 4:46 pm
Now, a team at Purdue University that typically tracks malaria spread in Southern and Central Africa is using its expertise to track COVID-19 in Indiana. Giovanna Carpi's lab studies the genomics of ...
- Scientists use malaria expertise to track COVID-19 variantson April 8, 2021 at 11:41 am
Scientists have been using genetics to track diseases for decades. Now, a team at Purdue University that typically tracks malaria spread in Southern and Central Africa is using its expertise to track ...
- Advances and opportunities in malaria population genomicson April 8, 2021 at 9:07 am
In this Review, Neafsey, Taylor and MacInnis discuss how population genomics approaches are currently used to study malaria parasites and mosquito vectors. They explore information that can be derived ...