“It’s not unreasonable to expect that in 10 years, this may become a widespread option for radiotherapy patients worldwide,” says study co-author Charles Limoli, professor of radiation oncology at UCI. Steve Zylius / UCI
Cancer treatment without side effects?
Treating cancer without debilitating side effects has long been the holy grail of oncologists, and researchers at the University of California, Irvine and Switzerland’s Lausanne University Hospital/University of Lausanne (CHUV/UNIL) may have found it.
Charles Limoli, professor of radiation oncology at UCI, and Marie-Catherine Vozenin, associate professor of radiation oncology at CHUV/UNIL, used an ultra-high dose rate of radiation therapy to eliminate brain tumors in mice, bypassing key side effects usually caused by cranial irradiation. Their findings are published in Clinical Cancer Research.
“It’s not unreasonable to expect that in 10 years, this may become a widespread option for radiotherapy patients worldwide,” Limoli said.
Traditional radiation therapy exposes a tumor and nearby normal tissue to radiation for several minutes at a time, but FLASH radiation therapy (FLASH-RT) allows delivery of the same dose in only tenths of seconds. The speed eliminates many of the toxicities that normally plague cancer survivors long after radiation treatments, significantly decreasing side effects such as inflammation and impairments to cognition.
As in traditional radiation therapy, the researchers fractionated the dose – divided the total over several sessions. Using FLASH-RT, they found that the same total dose of radiation delivered at quicker dose rates removed brain tumors just as effectively as the traditional method.
“This is very important, since fractionation is the standard in the clinic and the easiest way to transfer FLASH-RT at the clinical level,” said principal investigator Vozenin, an adjunct professor at UCI.
Though this work focused on the brain, FLASH-RT has also been used to treat lung, skin and intestinal cancers, while still preventing many radiation-induced complications. These additional studies have been successful across several types of animals, including fish, mice, pigs, cats and one human subject.
“It seems that this treatment is going to be universally beneficial for most cancer types,” Limoli said.
Now that researchers have verified that the method works, groups around the world are developing machines that would make FLASH technology available in clinics. One device is awaiting approval in the U.S. and Europe, and Vozenin plans to use it in two clinical trials at CHUV early next year.
Meanwhile, she and Limoli are investigating the mechanisms behind FLASH-RT’s beneficial effects to better understand how the technology works.
Said Limoli: “In the last 30 or 40 years, I’d say, there’s been nothing in the field of radiation sciences as exciting as this.”
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Inside Metro Exodus Enhanced Edition: the first triple-A ray tracing gameon April 28, 2021 at 8:00 am
This is it: the first triple-A game release that will only work on ray tracing capable graphics hardware. Metro Exodus Enhanced Edition takes the real-time RT global illumination of the initial PC ...
- Broncos 2021 Third Round NFL Draft Boardon April 28, 2021 at 8:00 am
If you did not see my second round board, you can catch it here. If you did, a quick reminder: the NFL Draft is an inexact science. I see my role in the process as something akin to an intermediary.
- Microsoft Surface RTon April 27, 2021 at 4:59 pm
Microsoft Surface RT tablet was launched in October 2012. The tablet comes with a 10.60-inch display with a resolution of 1366x768 pixels at a pixel density of 148 pixels per inch (ppi).
- A Homebrew Weller RT Soldering Stationon April 26, 2021 at 5:00 pm
Like a number of hackers before him, [MarcelMG] was impressed with Weller’s RT soldering iron tips ... footsteps uses something with a bit more flash under the hood. The LED display is a ...
- Windows RT Jailbreak Allows Unsigned Apps To Runon April 24, 2021 at 6:46 pm
Windows RT is pretty darn similar to Windows 8 ... As per the renders, it will have a flash-less camera on its back. Prakhar Khanna 16 April 2021 07:50EDT Here’s why I’m not upgrading to ...
Go deeper with Google Headlines on:
Go deeper with Bing News on:
FLASH radiation therapy
- Shoot right through: FLASH protons could eliminate Bragg peak constraintson April 30, 2021 at 1:45 am
The protective effect of FLASH irradiation enables proton treatments with beams shooting straight through the patient ...
- Nonfatal Scald-related Burns among Adults Aged ≥65 Years — United States, 2001–2006on April 12, 2021 at 5:00 pm
Visits were excluded if the burn involved only smoke, fire, chemical, electrical, radiation, or flash burns. Patients who were dead on arrival or died shortly thereafter were excluded. All ED ...
- Trend is expected to propel the Superficial Radiation Therapy Systems Market between 2020 and 2030on April 12, 2021 at 1:01 am
IntraOp Medical Corp. has entered into a partnership with the Lausanne University Hospital for clinical trials of FLASH radiotherapy which includes superficial radiation therapy functionality. Also, ...
- Creation of 3D organoid models to fine-tune radiation dose for nasopharyngeal canceron March 30, 2021 at 5:00 pm
Delivering high dose radiation—in a smaller number of fractions ... it will be extremely exciting to study the effects of flash therapy on hypoxic radioresistant 3D models of NPC." ...
- Why You Should Retain Varian (VAR) in Your Portfolio Nowon March 25, 2021 at 6:50 am
from the FDA for the first-ever clinical trial of FLASH therapy, an experimental treatment modality delivering radiation therapy at ultra-high dose rates. These developments should boost Varian ...