via Kurzweil AI
Stimulating the nervous system using small electric current by acupuncture could tamp down systemic inflammation in the body, suggests new research in mice from a team of neuroscientists in the U.S. and China. The research, publishing August 12 in the journal Neuron, helps to map the neuroanatomical underpinnings of this ancient medical practice.
“Most Western medicine has been focusing on blocking the neural pathways of pain to relieve the symptoms, but there are so many pain pathways and so many ways to open each of them,” says senior author Qiufu Ma, a researcher at Harvard Medical School who has been studying the neuroanatomic basis of pain for years. Inspired by the core ideology of traditional Chinese medicine, which is to treat a disease by addressing the root cause, Ma and his team aim to target inflammation, a common source of human diseases and pain.
Previous studies have shown direct vagal nerve stimulations in the neck region can help reduce inflammation, but these experimental approaches require invasive procedures. With this in mind, Ma and his team set out to investigate whether and how electric stimulation using acupuncture, which only involves inserting thin needles through the skin, can modulate inflammation.
The team began by giving mice a 15-minute electroacupuncture at 3 mA at a specific site on the abdomen. This acupoint, dubbed ST25, has been associated with nerves of the spleen, which is a major organ involved in immune responses.
The team then simulated a life-threatening inflammatory condition that is often seen in patients suffering severe bacterial or virus infections by injecting mice with a compound called lipopolysaccharide (LPS). After injecting the treated mice with LPS, researchers found the serum levels of pro-inflammatory molecules in these animals was significantly lower than that of the control group. The mice’s survival rates also more than doubled. However, when the team gave mice the electroacupuncture after the LPS shot, the treated mice had much greater inflammation than those that were untreated and did not survive.
By comparing the effect of electroacupuncture in mice with an altered nervous system, the team determined that high intensity stimulation at the abdomen could excite norepinephrine-producing nerves that connect the spine and spleen. The norepinephrine then activated a particular type of receptors in the spleen that suppressed pro-inflammatory molecules. But when LPS was introduced first, another type of splenic receptors–pro-inflammatory in this case–became highly expressed, and the subsequent electroacupuncture therapy further enhanced inflammation.
“We were really surprised to find that the same input has completely opposite outcomes in different disease stages,” Ma says. “But a lot of the time, a patient would only come to us if they already have the disease. So we wanted to find out if there is a way to reduce inflammation as a treatment.”
The team then conducted electroacupuncture at a different acupoint, this time on mice’s hindlegs. They found stimulation at a low intensity of 0.5 mA for 15 minutes could significantly reduce pro-inflammatory molecule levels either before or after LPS-injection. Mice’s survival rate after electroacupuncture also increased by 1-fold or more. A genetically modified mice model suggests that low-level electroacupuncture at hindlegs reduced inflammation not though the spleen, but a different neural pathway involving the vagus nerves and the adrenal glands.
“Our study illustrated that electroacupuncture has neuroanatomic basis, but its efficacy and safety on humans need to be validated in clinical trials,” Ma says. “There’s still many questions unanswered about this medical practice and thus a lot of room to do more research.”
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Prevention and Treatment of Postoperative Nausea and Vomitingon April 6, 2021 at 5:00 pm
Nonpharmacologic and alternative medicine techniques for preventing and treating PONV include acupuncture, electroacupuncture, acupoint stimulation, acupressure, transcutaneous nerve stimulation ...
- Acupuncture effective for chronic muscular pain in cancer survivorson April 6, 2021 at 10:01 am
(HealthDay)—Electroacupuncture and auricular acupuncture are more effective than usual care at reducing chronic musculoskeletal pain in cancer survivors, according to a study published online ...
- Acupuncture Reduces Pain For Cancer Survivorson April 2, 2021 at 11:45 am
Memorial Sloan Kettering Cancer Center (New York), University of California (San Diego), and Veterans Administration Medical Center (Pennsylvania) researchers conclude that both electroacupuncture and ...
- Acupuncture Tops Usual Care for Pain in Cancer Survivorson April 1, 2021 at 1:56 pm
Electroacupuncture reduced patient-reported pain by 1.9 points versus usual care, and auricular acupuncture reduced patients' mean pain score by 1.6 points as compared with usual care, which ...
- Acupuncture May Reduce Chronic Pain in Cancer Survivorson March 30, 2021 at 8:00 am
In the Personalized Electroacupuncture vs. Auricular Acupuncture Comparativeness Effectiveness (PEACE) trial, researchers analyzed data from 360 cancer survivors (mean age, 62.1 years) and a mean ...
Go deeper with Google Headlines on:
Go deeper with Bing News on:
- Study Identifies New Role of BioAegis’ ‘Inflammation Regulator’ Gelsolin Relevant for a Range of Inflammatory Diseaseson April 8, 2021 at 4:11 pm
MORRISTOWN, N.J., April 08, 2021 (GLOBE NEWSWIRE) -- BioAegis Therapeutics Inc., a clinical stage, private company developing therapies for infectious, inflammatory and degenerative diseases based ...
- Study Identifies New Role of BioAegis’ ‘Inflammation Regulator’ Gelsolin Relevant for a Range ...on April 8, 2021 at 4:02 pm
Gelsolin is non-immunosuppressive unlike current treatments to quell inflammatory cytokines. MORRISTOWN, N.J., April 08, 2021 (GLOBE NEWSWIRE) -- BioAegis Therapeutics Inc., a clinical stage, private ...
- Systemic Inflammatory Disease Tied to Mortality After MI in Young Adultson April 8, 2021 at 5:41 am
Among patients with a first myocardial infarction (MI) at a young age, 2.5 percent have a diagnosis of systemic inflammatory disease (SID) and an increased risk for all-cause mortality during a median ...
- Inflammatory syndrome in children a 'delayed immune response' to coronavirus, study suggestson April 6, 2021 at 8:00 am
Scientists may have got more of a grasp on the somewhat mysterious inflammatory syndrome that can occur in children with the coronavirus. While youngsters rarely become seriously ill with the ...
- Inflammation May Contribute to Worse Long-Term Survival Rates in People With Rheumatic Diseaseon April 4, 2021 at 5:00 pm
Rheumatoid arthritis, lupus, and other autoimmune systemic inflammatory disorders may enhance the risk of fatal heart disease, data suggests. Learn about the link.