via Kurzweil AI
Stimulating the nervous system using small electric current by acupuncture could tamp down systemic inflammation in the body, suggests new research in mice from a team of neuroscientists in the U.S. and China. The research, publishing August 12 in the journal Neuron, helps to map the neuroanatomical underpinnings of this ancient medical practice.
“Most Western medicine has been focusing on blocking the neural pathways of pain to relieve the symptoms, but there are so many pain pathways and so many ways to open each of them,” says senior author Qiufu Ma, a researcher at Harvard Medical School who has been studying the neuroanatomic basis of pain for years. Inspired by the core ideology of traditional Chinese medicine, which is to treat a disease by addressing the root cause, Ma and his team aim to target inflammation, a common source of human diseases and pain.
Previous studies have shown direct vagal nerve stimulations in the neck region can help reduce inflammation, but these experimental approaches require invasive procedures. With this in mind, Ma and his team set out to investigate whether and how electric stimulation using acupuncture, which only involves inserting thin needles through the skin, can modulate inflammation.
The team began by giving mice a 15-minute electroacupuncture at 3 mA at a specific site on the abdomen. This acupoint, dubbed ST25, has been associated with nerves of the spleen, which is a major organ involved in immune responses.
The team then simulated a life-threatening inflammatory condition that is often seen in patients suffering severe bacterial or virus infections by injecting mice with a compound called lipopolysaccharide (LPS). After injecting the treated mice with LPS, researchers found the serum levels of pro-inflammatory molecules in these animals was significantly lower than that of the control group. The mice’s survival rates also more than doubled. However, when the team gave mice the electroacupuncture after the LPS shot, the treated mice had much greater inflammation than those that were untreated and did not survive.
By comparing the effect of electroacupuncture in mice with an altered nervous system, the team determined that high intensity stimulation at the abdomen could excite norepinephrine-producing nerves that connect the spine and spleen. The norepinephrine then activated a particular type of receptors in the spleen that suppressed pro-inflammatory molecules. But when LPS was introduced first, another type of splenic receptors–pro-inflammatory in this case–became highly expressed, and the subsequent electroacupuncture therapy further enhanced inflammation.
“We were really surprised to find that the same input has completely opposite outcomes in different disease stages,” Ma says. “But a lot of the time, a patient would only come to us if they already have the disease. So we wanted to find out if there is a way to reduce inflammation as a treatment.”
The team then conducted electroacupuncture at a different acupoint, this time on mice’s hindlegs. They found stimulation at a low intensity of 0.5 mA for 15 minutes could significantly reduce pro-inflammatory molecule levels either before or after LPS-injection. Mice’s survival rate after electroacupuncture also increased by 1-fold or more. A genetically modified mice model suggests that low-level electroacupuncture at hindlegs reduced inflammation not though the spleen, but a different neural pathway involving the vagus nerves and the adrenal glands.
“Our study illustrated that electroacupuncture has neuroanatomic basis, but its efficacy and safety on humans need to be validated in clinical trials,” Ma says. “There’s still many questions unanswered about this medical practice and thus a lot of room to do more research.”
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Electroacupuncture May Aid Depression-Related Insomnia
THURSDAY, July 14, 2022 (HealthDay News) -- Electroacupuncture (EA) treatment is safe and effective for insomnia in patients with depression, according to a study published online July 7 in JAMA ...
- Electroacupuncture may aid depression-related insomnia
Electroacupuncture (EA) treatment is safe and effective for insomnia in patients with depression, according to a study published online July 7 in JAMA Network Open. At week 8, the researchers ...
- Electroacupuncture Promising for Depression-Related Insomnia
Electroacupuncture (EA) may significantly improve sleep quality in patients with depression who also have insomnia, new research suggests. In a study of more than 200 adults with depression and ...
- Psychology & Psychiatry news
Electroacupuncture (EA) treatment is safe and effective for insomnia in patients with depression, according to a study published online July 7 in JAMA Network Open.
- Electroacupuncture Points to Improvements in Depression-Related Insomnia
Electroacupuncture added to standard care improved sleep quality in people with depression-related insomnia, a randomized clinical trial showed. At 8 weeks, a -6.2 point change (95% CI -6.9 to -5. ...
Go deeper with Google Headlines on:
Go deeper with Bing News on:
- Study suggests possible benefit from melatonin in COVID-19
A new study discusses the utility of vitamin C and melatonin as potentially therapeutic and capable of preventing acute lung injury in COVID-19.
- How does COVID-19 affect the heart? New clues arise
A new study suggests that the heart damage that COVID-19 sometimes causes may occur due to a mechanism involving the spike protein.
- The good news, and bad news, of inflammation
Is the body's response to injury good for you, or is it bad? It depends. Following short-term injury, infection and exercise, inflammation is your friend. In chronic, low-dose form, it may be to blame ...
- Anti-inflammatory Compound Shows Promise in Treating Severe COVID-19
An anti-inflammatory compound has shown promise in treating systemic inflammation and brain injury in patients with severe COVID-19. The corresponding stud | Drug Discovery And Development ...
- Can Inflammation Lead To Cognitive Issues? Past Research Says 'Yes', With Implications For Covid-19
Reports of cognitive issues following a bout of Covid-19 are now quite common. In some cases, these symptoms may persist for months or years as part of Long Covid. Prior research on cancer and aging ...
Go deeper with Google Headlines on:
No news articles