The TinyArray imager has the antibody testing accuracy of machines 100 times more expensive and can be deployed in low-resource areas around the world. Timothy Abram
Portable imager could massively increase testing across nation by end of 2020
A robust, low-cost imaging platform utilizing lab-on-a-chip technology created by University of California, Irvine scientists may be available for rapid coronavirus diagnostic and antibody testing throughout the nation by the end of the year.
The UCI system can go a long way toward the deployment of a vaccine for COVID-19 and toward reopening the economy, as both require widespread testing for the virus and its antibodies. So far, antibody testing in the U.S. has been too inaccurate or expensive to reach the necessary numbers.
But UCI investigators Weian Zhao, Per Niklas Hedde, Enrico Gratton and Philip Felgner believe that their new technology can help accelerate the testing process quickly and affordably. Their discovery appears in the journal Lab on a Chip, which is published by the Royal Society of Chemistry.
“We need to test millions of people a day, and we’re very far from that,” said Hedde, a project scientist in pharmaceutical sciences and the study’s lead author. “This accurate testing platform enables public health officers to implement individualized mitigation strategies that are needed to safely reopen the country and economy.”
How it works
Using blood from a finger prick, the UCI test probes hundreds of antibody responses to 14 respiratory viruses, including SARS-CoV-2, in a mere two to four hours. Identifying responses to viral infections with symptoms similar to those of COVID-19 will keep hospitals clear of patients with standard colds and flus.
The results are printed on a low-cost imaging platform. The TinyArray imager combines a 3D-printed prototype with an off-the-shelf LED and a small 5-megapixel camera to find markers for many antibodies simultaneously. This ensures accuracy equal to that of expensive imaging systems but makes the platform portable enough to deploy anywhere – at a cost of only $200.
The same device can also process the results of commonly used nose swab tests for SARS-CoV-2 so that patients can be tested for COVID-19 and its antibodies on a single platform.
Currently, most antibody tests only check for one or two antigens, the foreign substances that cause the body to produce antibodies.
“A month or two ago, testing was kind of regarded as the Wild West,” said Zhao, a professor of pharmaceutical sciences, adding that most SARS-CoV-2 antibody tests are “just not accurate.”
Systems that test for the full range of antibodies necessary for reliable results require imaging machines that cost $10,000 to $100,000 and are too bulky for widespread use. Areas without the resources to acquire one of these machines have to send their samples to external labs for testing, meaning that results take days instead of hours.
Large-scale testing will determine what percentage of the population had COVID-19 but never showed symptoms, which will have a big impact on public health and reopening decisions.
“What if it turns out that a larger percentage of the people in a community have already contracted the virus?” Zhao said. “This means you are closer to accomplishing herd immunity.”
And understanding what antibodies are produced and how long they last will be key in developing an effective vaccine and administering the right dosage. This may be critical for years to come if the virus mutates, requiring updates much like yearly flu vaccinations.
The UCI team has already completed 5,000 tests in Orange County, and the final goal is to test 20,000 samples per unit a day. The researchers are partnering with UCI startups Velox Biosystems Inc. and Nanommune Inc. to scale up production. They expect that the TinyArray imager will be ready to deploy across the U.S. by the end of 2020 and are working with scientists in Uruguay, Russia and Thailand to develop similar systems for their nations.
“This would be great for a low-income country,” Hedde said. “Because the device’s materials are cheap and easy to obtain, the platform is easy to manufacture and use in low-resource areas, making testing accessible on a world scale.”
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Coronavirus response | UI's COVID protocols up in the air for Fall
Several COVID-era additions from the university — like the classroom mask requirement and building door checkers — have melted away for the summer term.
- New Study Shows Critical Role of 1,5-Anhydroglucitol (1,5-AG) in COVID-19 Pathogenesis by Binding to the COVID-19 Spike Protein
5 anhydroglucitol blood test) was more accurate than hemoglobin A1c (HbA1c) and glucose for predicting mortality and severity in COVID-19 patients with diabetes. These results extended to COVID-19 non ...
- Our Blues actor Kim Woo Bin halts work after testing positive for Covid-19
Our Blues actor Kim Woo Bin halts work after testing positive for Covid-19. Bollywood News: Latest Bollywood News, Bollywood News Today, Bollywood Celebrity News, Breaking News, Celeb News, ...
- COVID-19 Detection Test Kits and Consumables Global Market Report 2022
Major players in the COVID-19 detection test kits and consumables market are Cepheid, BGI, Abbott Laboratories, BioFire Diagnostics, F. Hoffmann-La Roche, GenMark Diagnostics, Mylab Discovery ...
- COVID in California: S.F. urges boosters for children 5-11 as coronavirus cases rise
A number of people taking the Pfizer antiviral pill Paxlovid are reporting “rebound” COVID symptoms after taking the drug. People who worked as political signature gatherers created a cottage industry ...
Go deeper with Google Headlines on:
Go deeper with Bing News on:
Portable Covid-19 imager
- Laptop and Tablet PC Market 2022: Growth Insights, New Developments, Shares, Trends, Emerging Technologies
The complete report gives a two-layered image of the market. By knowing the worldwide income ... Final Report will add the analysis of the impact of COVID-19 on this industry. The momentum market ...
- PDF to Excel conversion: Your ultimate guide to the best tools
Need to extract data from PDF files into a spreadsheet so you can analyze it? Find out how seven PDF to Excel conversion tools fared in head-to-head tests with increasingly complex data sources.
- Sanja Matsuri festival with 3 ‘mikoshi’ returns to Asakusa area
The huge Sanja Matsuri festival featuring three portable “mikoshi” shrines returned on May 22 for the first time in three years to crowded streets in Tokyo’s Asakusa district and with some anti-virus ...
- Medical Imaging Informatics Market Size Worth $5.17Bn, Globally, by 2028 at 5% CAGR - Exclusive Report by The Insight Partners
Geography Medical Imaging Equipment Market Forecast to 2028 - COVID-19 Impact and Global Analysis By Product Type ( Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Nuclear Imaging, ...
- Near Infrared (NIR) Portable Spectrometer Market New Business Opportunities, Growth Rate, Development Trend and Feasibility Studies by 2029
A new business intelligence report released by Data Bridge Market Research with title “Near Infrared (NIR) Portable Spectrometer Market Report-Development Trends, Threats, Opportunities and ...