The twist of a single nanoparticle, floating freely in a liquid
For the first time, a single, twisted nanoparticle has been accurately measured and characterised in a lab.
Physicists at the University of Bath who study materials on the nanoscale – that is, molecules 10,000 smaller than a pinhead – made their groundbreaking observations using a new method for examining the shape of nanoparticles in 3D. This technique, called the hyper-Rayleigh scattering optical activity (HRS OA) technique, was used to examine the structure of gold (among other materials), resulting in an exceptionally clear image of the ‘screw thread’ twist in the metal’s shape.
Understanding the twists within a material (known as its chirality) is vital in industries that produce medicines, perfumes, food additives and pesticides, as the direction in which a molecule twists determines some of its properties. For instance, a molecule that twists clockwise will produce the smell of lemons while the identical molecule twisting anticlockwise (the mirror image of the lemon-smelling molecule) smells of oranges.
“Chirality is one of the most fundamental properties of nature. It exists in sub-atomic particles, in molecules (DNA, proteins), in organs (the heart, the brain), in bio-materials (such as seashells), in storm clouds (tornadoes) and in the shape of galaxies (spirals hurling through space).” said Professor Ventsislav Valev, who led the project.
Until now, physicists have relied on 200-year-old optical methods for determining the chiral properties of molecules and materials, but these methods are weak and require large amounts of molecules or materials to work. Through their use of a technique based on powerful laser pulses, Professor Valev and his team at Bath’s Centre for Photonics and Photonic Materials have produced a far more sensitive probe for chirality, one that can detect a single nanoparticle as it floats freely in a liquid.
This discovery was made by Bath’s Department of Physics in collaboration with the Department of Chemistry. The researchers’ findings are published in Nano Letters.
“This is both a record and a milestone in nanotechnology,” said Professor Valev. “Pursuing this line of research has been one of the most rewarding achievements in my career.”
“The observation by Valev’s group is historic, and scientifically it inspires us in our work to synthesise new chiral 3D nanomaterials,” said study co-author Professor Ki Tae Nam from Material Science and Engineering at the Seoul National University in Republic of Korea.
The potential applications for ultra-sensitive chiral sensing are many. For instance, many pharmaceuticals are chiral. Local pharmacists will be able to harness the technology to mix substances in a completely new way, producing pharmaceuticals from minute droplets of active ingredients rather than from large beakers of chemicals.
“You’ll be able to go to the chemist with a prescription and instead of receiving a medicine that has to be mixed from bottles of chemicals and then stored in the fridge for several days, you’ll walk away with pills that are mini-labs. Upon cracking the pill, a precise number of micro-droplets will flow through microchannels to mix and produce the needed medicine.” said Professor Valev.
“For these mini-labs to produce chiral drugs, you’ll need to know the number of molecules and catalysts within each micro droplet, as well as their chirality.” said PhD student Lukas Ohnoutek, who is the first author on the paper. “This is where our result is really important. We can now aim to produce microdroplets containing a single chiral nanoparticle, to use as catalysts in chemical reactions.”
Professor Valev added: “Looking ahead, we can imagine building up chiral materials and even machines, one nanoparticle at a time, from such microdroplets. To do so would be amazing.”
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Chiral 3D nanomaterials
- Chemistry (Weinheim an der Bergstrasse, Germany)on February 24, 2021 at 4:00 pm
Mixed Organometallic-Organic Hybrid Assemblies Based on the Diarsene Complex [Cp2 Mo2 (CO)4 (μ,η2 -As2 )], AgI Salts and N-Donor Organic Molecules. Sensitive and Visual Detection of Phosgene by ...
- Chromatography and Nanotechnologyon February 22, 2021 at 9:36 pm
Nanomaterials have been used in many different types of LC including reversed and normal phase LC, ion-exchange modes, as well as chiral separations, and hydrophilic interaction liquid chromatography.
- Self-assembling peptide scaffolds in the clinicon February 17, 2021 at 7:00 am
Self-assembling peptide (SAP) scaffolds can be traced back to the fundamental discoveries made in 1951 by Pauling et al., who reported the molecular structures of the most fundame ...
- Molecular cannibalism: Sacrificial materials as precursors for hollow and multidomain single crystalson February 11, 2021 at 2:37 am
The chiral crystals are formed from achiral components ... the stability of the isostructural crystals is related to the 3D metal-organic networks, and not affected by the different morphology ...
- Submilligram-scale separation of near-zigzag single-chirality carbon nanotubes by temperature controlling a binary surfactant systemon February 3, 2021 at 4:00 pm
6 Nanomaterials Research Institute ... Here, we report a method to separate SWCNTs by chiral angle through temperature control of a binary surfactant system of sodium cholate (SC) and SDS in gel ...
Go deeper with Google Headlines on:
Chiral 3D nanomaterials
Go deeper with Bing News on:
Chiral drugs
- Light-twisting ‘chiral’ nanotechnology could accelerate drug screeningon March 1, 2021 at 6:33 am
These structures appear bright red when viewed between two oppositely angled polarizers, or light filters, because their twisting, chiral shapes can turn the polarization of the light. “The strong ...
- Light-twisting 'chiral' nanotechnology could accelerate drug screeningon March 1, 2021 at 3:20 am
In a new drug-screening technique that relies on gold ... biological molecules like proteins, and lightwaves. A chiral object cannot be superimposed on its mirror image, like a left and right ...
- Light-twisting 'chiral' nanotechnology could accelerate drug screeningon February 26, 2021 at 6:29 am
chiral shapes can turn the polarization of the light. "The strong twisting of the light allows for the drug screening results to be seen with the naked eye, instead of using complicated ...
- Flumazenil Market Size, Share, Industry, Trends, Growth, Report and Forecast 2020-2027on February 23, 2021 at 4:00 pm
The MarketWatch News Department was not involved in the creation of this content. Japan, Japan, Tue, 23 Feb 2021 23:58:17 / Comserve Inc. / -- Competitive Analysis: ScinoPharm Taiwan, Midas Pharma ...
- Rapid communications in mass spectrometry : RCMon February 17, 2021 at 4:00 pm
Micelles of the chiral biocompatible surfactant (1R ... and fragmentation patterns in the gas phase. Immunosuppressive drugs in whole blood: validation of a commercially available liquid ...