Bioinspired research project a first step toward intrinsically translucent tissue
Octopuses, squids and other sea creatures can perform a disappearing act by using specialized tissues in their bodies to manipulate the transmission and reflection of light, and now researchers at the University of California, Irvine have engineered human cells to have similar transparent abilities.
In a paper published today in Nature Communications, the scientists described how they drew inspiration from cephalopod skin to endow mammalian cells with tunable transparency and light-scattering characteristics.
“For millennia, people have been fascinated by transparency and invisibility, which have inspired philosophical speculation, works of science fiction, and much academic research,” said lead author Atrouli Chatterjee, a UCI doctoral student in chemical & biomolecular engineering. “Our project – which is decidedly in the realm of science – centers on designing and engineering cellular systems and tissues with controllable properties for transmitting, reflecting and absorbing light.”
Chatterjee works in the laboratory of Alon Gorodetsky, UCI associate professor of chemical & biomolecular engineering, who has a long history of exploring how cephalopods’ color-changing capabilities can be mimicked to develop unique technologies to benefit people. His team’s bioinspired research has led to breakthrough developments in infrared camouflage and other advanced materials.
For this study, the group drew inspiration from the way female Doryteuthis opalescens squids can evade predators by dynamically switching a stripe on their mantle from nearly transparent to opaque white. The researchers then borrowed some of the intercellular protein-based particles involved in this biological cloaking technique and found a way to introduce them into human cells to test whether the light-scattering powers are transferable to other animals.
This species of squid has specialized reflective cells called leucophores which can alter the how they scatter light. Within these cells are leucosomes, membrane-bound particles which are composed of proteins known as reflectins, which can produce iridescent camouflage.
In their experiments, the researchers cultured human embryonic kidney cells and genetically engineered them to express reflectin. They found that the protein would assemble into particles in the cells’ cytoplasm in a disordered arrangement. They also saw through optical microscopy and spectroscopy that the introduced reflectin-based structures caused the cells to change their scattering of light.
“We were amazed to find that the cells not only expressed reflectin but also packaged the protein in spheroidal nanostructures and distributed them throughout the cells’ bodies,” said Gorodetsky, a co-author on this study. “Through quantitative phase microscopy, we were able to determine that the protein structures had different optical characteristics when compared to the cytoplasm inside the cells; in other words, they optically behaved almost as they do in their native cephalopod leucophores.”
In another important part of the study, the team tested whether the reflectance could potentially be toggled on and off through external stimuli. They sandwiched cells in between coated glass plates and applied different concentrations of sodium chloride. Measuring the amount of light that was transmitted by the cells, they found that the ones exposed to higher sodium levels scattered more light and stood out more from the surroundings
“Our experiments showed that these effects appeared in the engineered cells but not in cells that lacked the reflectin particles, demonstrating a potential valuable method for tuning light-scattering properties in human cells,” Chatterjee said.
While invisible humans are still firmly in the realm of science fiction, Gorodetsky said his group’s research can offer some tangible benefits in the near term.
“This project showed that it’s possible to develop human cells with stimuli-responsive optical properties inspired by leucophores in celphalopods, and it shows that these amazing reflectin proteins can maintain their properties in foreign cellular environments,” he said.
He said the new knowledge also could open the possibility of using reflectins as a new type of biomolecular marker for medical and biological microscopy applications.
This project, which received support from Defense Applied Research Projects Agency and the Air Force Office of Scientific Research, also involved researchers from the University of California, San Diego and Hamamatsu Photonics in Japan.
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Microscopy of Catalysis Makes It Clear Why Some Effects Can't Be Predicted
Scientists use microscopy techniques to observe chemical reactions on catalysts more precisely than before yielding a wealth of detail.
- Why Do Squid Turn Translucent When They Die?
YouTube is full of videos showing fishermen — almost all of them Australian — employing a swift, hard “karate chop” to dispatch squid that they had caught. The apparently letha ...
- The Best Face Masks for a Clean, Clear Complexion
A good face mask will cleanse, hydrate, or exfoliate your way to a smooth and bright complexion—and force you to relax for a second.
- Survival Benefit With Lenvima/Keytruda for Advanced Clear Cell RCC Continues After 4 Years
After a median follow-up of four years, the survival benefit, including progression-free survival persisted in patients with advanced clear cell renal cell carcinoma treated with Lenvima plus Keytruda ...
- Amazon Prime could eventually include cheap cell service
Maybe someday Amazon Prime will include your rent and health insurance, too.Well, probably not, but one recent report indicates that Amazon wants Prime to intrude on yet another part of your life.
Go deeper with Google Headlines on:
[google_news title=”” keyword=”translucent cells” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
- Toy Cars and Camouflage: Tales from Humboldt’s Only Strip Club
If they wanted to stay in Humboldt they had to do something.” She laughs, “I remember camo being the factor that brought them together. Camouflage clothing was the one thing they shared.” ...
- Active Camouflage Material Shows Promise At Hiding From Infrared Or Visual Detection
At our current level of technology, more practical efforts focus on what is known as active camouflage. This is more akin to the way animals like squid and chameleons alter their appearance to ...
- Can you spot the hidden animals that use cunning camouflage?
Animals have evolved a range of camouflage tactics, from simple colour matching to sophisticated mimicry. See if you can spot the creatures in the photos below - drag the slider to reveal them. Will ...
- A new approach to warding off mice eating wheat seed using camouflage scents
A mouse digging at a patch treated with wheat germ oil. Credit: Peter Banks They were surprised to find that the oil did not serve as a false signal; the mice still ate the seeds where the plots ...
- How to fool a mouse: ‘chemical camouflage’ can hide crops and cut losses by over 60%
In a research paper published today, we show how “chemical camouflage” can prevent house mice finding newly sown wheat seeds. The method reduced mouse damage to wheat crops by more than 60% ...
Go deeper with Google Headlines on:
[google_news title=”” keyword=”iridescent camouflage” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]