3 women smile after exercising together in the park.
Having greater amounts of the peptide humanin is closely correlated with longer lives and better health in both animals and humans, including lower risk for Alzheimer’s.
A new study led by researchers at the USC Leonard Davis School of Gerontology is the first to demonstrate that a tiny protein has a big impact on health and longevity in both animals and humans.
The researchers examined humanin, a peptide encoded in the small genome of mitochondria — the powerhouses of the cell. From experiments in laboratory animals to measurements in human patients, the multi-site collaboration demonstrates how higher levels of humanin in the body are connected to longer lifespans and better health. It is linked to a lower risk for diseases such as Alzheimer’s.
“Humanin has long been known to help prevent many age-related diseases, and this is the first time that it has been shown that it can also increase lifespan,” said senior author Pinchas Cohen, professor of gerontology, medicine and biological sciences and dean of the USC Leonard Davis School.
An intriguing evolutionary history
Humanin has been found not only in human mitochondria but also throughout the animal kingdom, a sign that its related gene has been maintained, or conserved, throughout evolution. The study, which was published online in the journal Aging on June 23, examined humanin in several animal species, including worms and mice, as well as humans, including Alzheimer’s patients and children of centenarians.
The results highlight the potential for humanin and other mitochondrial proteins to become treatments for age-related ailments. They also indicate that humanin may be an ancient mitochondrial signaling mechanism that is key for regulating the body’s health and lifespan, said first author and USC Leonard Davis Research Assistant Professor Kelvin Yen.
More humanin, longer lifespans
Humanin levels have previously been observed to decrease with age in many species. In this new study, the scientists observed higher levels of humanin in organisms predisposed to long lives, including the famously age-resistant naked mole rat, which experiences only a very slow decline in levels of humanin circulating in the body throughout its 30-year lifespan.
In contrast, mice experience a 40% drop in humanin over the first 18 months of life, and primates such as rhesus macaques appeared to have a similarly dramatic drop in humanin between the ages of 19 and 25.
In humans, researchers observed this phenomenon of higher and more sustained levels of humanin in 18 children of centenarians, versus a control group of 19 children of non-centenarians. Individuals whose parents reach 100 years old are statistically more likely than other people to reach very old age.
In some species, including worms and mice, modifying their genes to produce higher amounts of humanin within their bodies was enough to significantly increase lifespans. But these longer-lived animals had fewer offspring. Scientists have observed a similar pattern in long-lived humans.
“This tradeoff between longevity and reproduction is thought to be due to an evolutionarily conserved balance between using energy to produce more offspring or using the energy to maintain the organism for future reproductive efforts,” Yen said. “Evolutionarily speaking, the goal of life is to reproduce and then you’re done, but if you can’t reproduce, you should try to hang around as long as possible, and a side effect of that is longevity.”
Indication of – and protection against – disease
Higher humanin levels aren’t just linked to increased lifespan; lower levels may increase the risk of disease and lower resistance to toxic exposures.
The researchers analyzed samples of cerebral spinal fluid from a small number of Alzheimer’s patients and control individuals without dementia and noticed that humanin levels were much lower in the Alzheimer’s patients. And in newborn cord blood samples, high levels of humanin correlated with a high mitochondrial DNA (mtDNA) copy number, or the number of copies of the mitochondrial genome present within each cell.
“Humanin levels are inversely correlated with a decrease in mitochondrial DNA (mtDNA) copy number, which in itself has been associated with a number of different diseases such as cancer, kidney disease, and cardiovascular disease,” Yen said.
Potential for treatments
Cohen’s laboratory was one of three groups that independently discovered humanin and has continued to unlock the secrets of the mitochondrial genome. Other promising mitochondrial peptides characterized by Cohen’s team include MOTS-c, which plays a role in communication between the mitochondria and the nucleus in cells and appears to mimic the effects of exercise.
This new wide-ranging study highlights the importance of humanin as a potentially powerful regulator of lifespan and health, and harnessing it for treatments could address a variety of age-related illnesses, Cohen said.
“This study, as well as many others, suggest that humanin administration would be an effective therapeutic treatment for a large number of diseases and further solidifies the importance of the mitochondria beyond its traditional role as the ‘powerhouse of the cell,’” he said.
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- $300 enhanced unemployment benefits could be extended past September 6. Here's how.on August 19, 2021 at 2:26 pm
BALTIMORE (WBFF) — The stimulus bills signed into law delivered a lot of payments to people struggling through the coronavirus pandemic. The help included things like checks sent to every ...
- What is Bryce Hall's net worth? TikTok star claims someone stole his checkbook and "robbed" $8,200on August 19, 2021 at 4:00 am
Bryce Hall is allegedly an angel investor in multiple companies including Lendtable, Humanin, AON3D and Stir. Bryce Hall is also co-founder of Ani-Energy, a caffienated energy drink, with fellow ...
- Women’s Giving Circle of Harford County awards more than $43,000 in grantson August 3, 2021 at 8:33 am
to Humanim, Inc. for its Administrative Assistant Career Training Program; to Mason-Dixon Community Services, Inc. for its Summer Backpack Nutrition Program; and to The Sexual Assault/Spouse Abuse ...
- Fluorescence Lifetime Imaging Microscopy of Peptides. (IMAGE)on July 29, 2021 at 9:43 am
exhbiting co-localization of humanin and mito-tracker at the mitochondria. Both trackers are co-localized where their lifetime is the longest. Disclaimer: AAAS and EurekAlert! are not responsible ...
- Biophytis Reinforces Leadership Teams with Three Senior Appointmentson July 7, 2021 at 11:20 pm
He devotes an important part of his time to Patients' Associations. He recently co-founded new service companies: Humanim (Life Sciences Manufacturing) and Les Mauvais Elèves (Think Tank on work ...
Go deeper with Google Headlines on:
Go deeper with Bing News on:
- Find Out How Your Longevity Compares to the People With the Longest Lifespans in the Worldon August 27, 2021 at 11:15 am
I have a pretty bad case of existential denial. If anyone's going to make me contemplate the possibility of a long life, however, it's the people of the Blue Zones, who just so happen to be the ...
- Screen Grabs: The dazzling longevity of Fellini’s ‘8 1/2’on August 27, 2021 at 10:31 am
A new 4K restoration is playing the Roxie’s big house this Sat/28 (4pm), Sun/29 (1:20pm), and Thurs/4 (8:35pm). More info here. Alongside that nearly 60-year-old monument, the newly released features ...
- 10 of the Most Antioxidant-Rich Foods That Help Fight Inflammation and Promote Longevityon August 27, 2021 at 9:00 am
What are antioxidants? They're compounds that fight free radical damage and inflammation. Here, the top 10 antioxidant foods per an RD.
- State looking for centenarians to highlight their longevityon August 27, 2021 at 7:57 am
If you or someone you know is 100 or older — the Iowa Department on Aging wants to hear from you. The Department has long held an annual recognition of centenarians, and spokesperson Marissa Vance ...
- Woodcarvings explore symbol of longevityon August 26, 2021 at 5:38 pm
The Artery, at 207 G St. in Davis, presents the woodcarvings of Diana Kwan with her show “Gingko and Friends.” An award-wining artist, Kwan pays tribute to this ageless symbol of longevity and ...