via Johns Hopkins University
Perhaps no region of the brain is more fittingly named than the claustrum, taken from the Latin word for “hidden or shut away.” The claustrum is an extremely thin sheet of neurons deep within the cortex, yet it reaches out to every other region of the brain. Its true purpose remains “hidden away” as well, with researchers speculating about many functions. For example, Francis Crick of DNA-discovery fame believed that the claustrum is the seat of consciousness, responsible for awareness and sense of self.
What is known is that this region contains a large number of receptors targeted by psychedelic drugs such as LSD or psilocybin ¾ the hallucinogenic chemical found in certain mushrooms. To see what happens in the claustrum when people are on psychedelics, Johns Hopkins Medicine researchers compared the brain scans of people after they took psilocybin with their scans after taking a placebo.
Their findings were published online on May 23, 2020, in the journal NeuroImage.
The scans after psilocybin use showed that the claustrum was less active, meaning the area of the brain believed responsible for setting attention and switching tasks is turned down when on the drug. The researchers say that this ties in with what people report as typical effects of psychedelic drugs, including feelings of being connected to everything and reduced senses of self or ego.
“Our findings move us one step closer to understanding mechanisms underlying how psilocybin works in the brain,” says Frederick Barrett, Ph.D., assistant professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine and a member of the school’s Center for Psychedelic and Consciousness Research. “This will hopefully enable us to better understand why it’s an effective therapy for certain psychiatric disorders, which might help us tailor therapies to help people more.”
Because of its deep-rooted location in the brain, the claustrum has been difficult to access and study. Last year, Barrett and his colleagues at the University of Maryland, Baltimore, developed a method to detect brain activity in the claustrum using functional magnetic resonance imaging (fMRI).
For this new study, the researchers used fMRI with 15 people and observed the claustrum brain region after the participants took either psilocybin or a placebo. They found that psilocybin reduced neural activity in the claustrum by 15% to 30%. This lowered activity also appeared to be associated with stronger subjective effects of the drug, such as emotional and mystical experiences. The researchers also found that psilocybin changed the way that the claustrum communicated with brain regions involved in hearing, attention, decision-making and remembering.
With the highly detailed imaging of the claustrum provided by fMRI, the researchers next hope to look at the mysterious brain region in people with certain psychiatric disorders such as depression and substance use disorder. The goal of these experiments will be to see what roles, if any, the claustrum plays in these conditions. The researchers also plan to observe the claustrum’s activity when under the influence of other psychedelics, such as salvinorin A, a hallucinogen derived from a Mexican plant.
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
- Drew Barrymore Hasn’t Dated Anybody Since 6-Long-Years: “I Need To Try An MDMA Treatment Or Psilocybin As A Way…”
Drew has barely dated since splitting from Will Kopelman - the father of her daughters Olive, 10, and nine-year-old Frankie - in 2016.
- First-Of-Its-Kind Study Reveals How Psilocybin Therapy Helps Treat Alcohol Addiction
Several studies have found psilocybin to be safe and effective in treating substance use disorders—but a first-of-its-kind analysis released on Monday is offering novel insights into exactly how ...
- Psilocybin Therapy: Potential For Treating Alcoholism Examined In APA Publication
The peer-reviewed journal Psychology of Addictive Behaviors published by the American Psychological Association (APA) released a new analysis by Fluence, NYU and U C-SF of a clinical trial of ...
- Enveric Stock Trading Higher On Notice Of Allowance For Patent Application For Its Carboxylated Psilocybin Derivatives
The soon-to-issue patent titled, “Carboxylated Psilocybin Derivatives and Methods of Using” contains composition of matter claims for a family of tryptamine-based drug candidates. Enveric is ...
- Revolutionizing Mental Health: The Rise of Psilocybin Therapy in New York
In recent years, there has been a groundbreaking shift in the field of mental health as researchers and practitioners explore the therapeutic potential of psilocybin, a naturally occurring psychedelic ...
Go deeper with Google Headlines on:
[google_news title=”” keyword=”psilocybin” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
- Drew Barrymore Considering Psychedelics To Explore Why She's Not Open To Relationship
Barrymore became a worldwide star at age 7 with a starring role in Steven Spielberg’s “E.T.” in 1982. She has previously spoken about the turbulence of child stardom, navigating the perilous industry ...
- PSYC’s Psychedelic Spotlight Continues Ascent as a Top-Ranking Multimedia Platform for the Psychedelics Sector
LAS VEGAS, NV, June 06, 2023 (GLOBE NEWSWIRE) -- (OTC Pink Market: PSYC) (“PSYC”, “PSYC Corp” or the “Company”), parent company to Spotlight Media Corporation (“SMC” or the “wholly owned subsidiary”) ...
- $42M for psychedelics research is not how Kentucky should be fighting opioid addiction
The $42 million being allocated for ibogaine research is coming from Kentucky’s Opioid Settlement Fund. This fund was developed following a 2022 nationwide agreement with major ...
- 6 Benefits of Microdosing Psychedelics — Can It Really Help?
An expert shares the truth about the mental health benefits of microdosing, and how to know if it's right for you.
- Antidepressant Psychedelics With No Hallucinations May Finally Be Possible
Researchers have recently shown that separate mechanisms drive the hallucinogenic and antidepressant effects of psychedelics like LSD and psilocin, potentially paving the way to use these 'party drugs ...
Go deeper with Google Headlines on:
[google_news title=”” keyword=”psychedelics” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]