via Mayo Clinic
Mayo Clinic researchers have uncovered stem cell-activated mechanisms of healing after a heart attack. Stem cells restored cardiac muscle back to its condition before the heart attack, in turn providing a blueprint of how stem cells may work.
The study, published in NPJ Regenerative Medicine, finds that human cardiopoietic cells zero in on damaged proteins to reverse complex changes caused by a heart attack. Cardiopoietic cells are derived from adult stem cell sources of bone marrow.
“The extent of change caused by a heart attack is too great for the heart to repair itself or to prevent further damage from occurring. Notably, however, cardiopoietic stem cell therapy reversed, either fully or partially, two-thirds of these disease-induced changes, such that 85% of all cellular functional categories affected by disease responded favorably to treatment,” says Andre Terzic, M.D., Ph.D., director of Mayo Clinic’s Center for Regenerative Medicine. Dr. Terzic is the senior author of the study.
This new understanding of how stem cells restore heart health could provide the framework for broader applications of stem cell therapy across various conditions.
“The actual mode of action of stem cells in repairing a diseased organ has until now been poorly understood, limiting adoption in clinical care. This study sheds light on the most intimate, yet comprehensive, regenerative mechanisms ? paving a road map for responsible and increasingly informed stem cell application,” says Dr. Terzic.
Heart disease is a leading cause of death in the U.S. Every 40 seconds, someone in the U.S. has a heart attack, according to the Centers for Disease Control and Prevention. During a heart attack, cardiac tissue dies, weakening the heart.
“The response of the diseased heart to cardiopoietic stem cell treatment revealed development and growth of new blood vessels, along with new heart tissue,” adds Kent Arrell, Ph.D., a Mayo Clinic cardiovascular researcher and first author of the study.
Researchers compared the diseased hearts of mice that did not receive human cardiopoietic stem cell therapy with those that did. Using a data science approach to map all the proteins in the heart muscle, researchers identified 4,000 cardiac proteins, more than 10% of which suffered damage by a heart attack.
“While we anticipated that the stem cell treatment would produce a beneficial outcome, we were surprised how far it shifted the state of diseased hearts away from disease and back toward a healthy, pre-disease state,” says Dr. Arrell.
Cardiopoietic stem cells are being tested in advanced clinical trials in heart patients.
“The current findings will enrich the base of knowledge pertinent to stem cell therapies and may have the potential to guide therapeutic regimens in the future,” says Dr. Terzic.
The Latest Updates from Bing News & Google News
Go deeper with Bing News on:
Stem cell therapies
- The Global Stem Cell Market Estimated to Reach $16782.2 Million in Revenue by 2028on January 22, 2021 at 4:21 am
According to Triton s report the global stem cell market which garnered 9382 million in 2020 is predicted to advance at 7 54 of CAGR by 2028 A recent study by Triton Market Research titled Global Stem ...
- Stem Cell Therapy: A Breakthrough Against MS?on January 21, 2021 at 10:53 pm
Stem cell transplants may have long-lasting benefits for some people with aggressive cases of multiple sclerosis, a new study suggests.
- I Have MS and Tried a Stem Cell Transplanton January 21, 2021 at 1:39 pm
And I just sat on the floor and cried.” A neurologist at the Ottawa, Canada, hospital where Molson was getting treatment suggested she join a clinical trial that was exploring whether a stem cell ...
- Could Stem Cell Therapy Be a Breakthrough Against MS?on January 21, 2021 at 12:08 pm
Stem cell transplants may have long-lasting benefits for some people with aggressive cases of multiple sclerosis, a new study suggests. Italian researchers found that among 210 multiple sclerosis (MS) ...
- Designer DNA molecule helps hunt down cancer stem cells in bloodon January 20, 2021 at 10:03 pm
Like weeds that grow back if you don’t remove the roots, cancer can keep returning thanks to lurking stem cells. Now, researchers have developed a “designer” DNA segment that can eradicate these ...
Go deeper with Google Headlines on:
Stem cell therapies
Go deeper with Bing News on:
Stem cells repair heart damage
- Stem Cells Market to Reach USD 17.78 Billion | Global Size Analysis, Segmentation, Industry Outlook, and Forecasts 2021-2027on January 20, 2021 at 3:19 am
Similarly, embryonic stem cell-derived cells may be used to replace tissues that have been damaged by injury or disease, including heart attacks, Parkinson’s disease, diabetes or spinal cord injury.
- Scientists closer to developing 'smart' stem cells made from human faton January 17, 2021 at 1:58 pm
Much controversy has surrounded stem cell research, and yet therapies and treatments involving stem cells have the capacity to treat a wide range of medical conditions. Stem cell therapy could be used ...
- Stem Cells in Cardiac Repairon January 16, 2021 at 4:00 pm
Although different stem ... reach the heart, many stem cells become lodged in the lungs. Consequently, with intravenous injections, the number of stem cells required for cardiac repair can be ...
- Scientists are a step closer to developing 'smart' stem cells – and they're made from human faton January 14, 2021 at 3:33 pm
"The stem cells we've developed can adapt to their surroundings and repair a range of damaged ... mend anything from traumatic injuries to heart damage. "This is one step further in the field ...
- Stem cells with regenerative abilities could be closer on the horizon, shows studyon January 13, 2021 at 4:00 pm
The stem cells we've developed can adapt to their surroundings and repair a range of damaged ... mend anything from traumatic injuries to heart damage. "This is one step further in the field ...