Perelman School of Medicine at the University of Pennsylvania

The Perelman School of Medicine, commonly known as Penn Med, is the medical school of the University of Pennsylvania

Reversing blindness with a single injection of a mutation-specific RNA therapy in a patient with a rare genetic disorder

Researchers appear to have halted the osteoporosis process that breaks down bone – in mice

Using magnets to arrange cells to grow new tissues like cartilage

Is giving an entire course of radiation therapy in less than 1 second possible?

Imagine using gene therapy to correct lethal lung diseases before death

Using CRISPR gene editing, a team from Children’s Hospital of Philadelphia (CHOP) and Penn Medicine have thwarted a lethal lung disease in an animal model in which a harmful mutation causes death within hours after birth. This proof-of-concept study, published today in Science Translational Medicine, showed that in uteroediting could be a promising new approach for treating lung diseases

Imagine using gene therapy to correct lethal lung diseases before death

Proof-of-concept in treating congenital disease before birth using CRISPR pre-natal gene editing

CHOP/Penn Medicine Team Shows first example of base-editing tool to treat a disease in utero in animal models For the first time, scientists have performed prenatal gene editing to prevent a lethal metabolic disorder in laboratory animals, offering the potential to treat human congenital diseases before birth. Published today in Nature Medicine, research from Children’s Hospital of Philadelphia (CHOP) and the Perelman

Proof-of-concept in treating congenital disease before birth using CRISPR pre-natal gene editing

Could the intent to commit assault be diminished by electrical brain stimulation?

Research from the University of Pennsylvania shows that using minimally invasive electrical currents on the prefrontal cortex can reduce the desire to carry out physical and sexual assault and increase the perception that such violence is morally wrong Stimulating the prefrontal cortex, the part of the brain responsible for controlling complex ideas and behaviors, can

Could the intent to commit assault be diminished by electrical brain stimulation?

Could simple baking soda boost cancer therapy?

Ludwig researchers describe how acidity turns oxygen-starved cancer cells dormant and drug resistant—and a potentially easy way reverse the effect. A Ludwig Cancer Research study has uncovered an entirely novel mechanism by which cells enter a state of dormancy as tissues starved of oxygen become increasingly acidic. The study, led by Chi Van Dang, scientific

Could simple baking soda boost cancer therapy?

Gene therapy for macular degeneration?

Researchers from the University of Pennsylvania have developed a gene therapy that successfully treats a form of macular degeneration in a canine model. The work sets the stage for translating the findings into a human therapy for an inherited disease that results in a progressive loss of central vision and which is currently untreatable. The study, published

Gene therapy for macular degeneration?

Reducing triglycerides and cholesterol by up to 50 percent with gene editing

CRISPR-like technique offers clues to mimic protective genetic mutations Using a variation of CRISPR gene editing may be a potential strategy for mimicking the protective effects of a genetic mutation linked to lower cholesterol levels and heart disease risks, according to new mouse research from the Perelman School of Medicine at the University of Pennsylvania published this week

Reducing triglycerides and cholesterol by up to 50 percent with gene editing

Injectable gel helps heart muscle regenerate after a heart attack

Turning on repair mechanisms in cells that survive injury in the heart and other tissues In mammals, including humans, the cells that contract the heart muscle and enable it to beat do not regenerate after injury. After a heart attack, there is a dramatic loss of these heart muscle cells and those that survive cannot

Injectable gel helps heart muscle regenerate after a heart attack

Sleep deprivation can reduce depression in almost 50 percent of depression patients

Sleep deprivation – typically administered in controlled, inpatient settings – rapidly reduces symptoms of depression in roughly half of depression patients, according the first meta-analysis on the subject in nearly 30 years, from researchers at the Perelman School of Medicine at the University of Pennsylvania. Partial sleep deprivation (sleep for three to four hours followed by

Sleep deprivation can reduce depression in almost 50 percent of depression patients

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Perelman School of Medicine at the University of Pennsylvania Research

Founder’s Medalists to be recognized at Class of 2020 Commencement
on April 30, 2021 at 6:00 am
The 10 students who graduated with first honors from each of Vanderbilt’s schools and colleges will be recognized during the Class of 2020’s Commencement exercises on Saturday, May 1, and Sunday, May ...
Four Penn faculty elected to the National Academy of Sciences
on April 29, 2021 at 4:58 am
Four members of the University of Pennsylvania faculty have been elected to the United States National Academy of Sciences (NAS). They are Marisa Bartolomei and M. Celeste Simon from the Perelman ...
Penn College of Liberal and Professional Studies student Christina Goessman dies at 24
on April 28, 2021 at 10:07 pm
Christina Goessman, a student in the College of Liberal and Professional Studies, died on Sunday at the Hospital of the University of Pennsylvania after suffering a brain aneurysm. Vice Provost for ...
Applied Cells Inc. Enters Collaborative Research Agreement for Rare Cell Isolation in Minimum Residual Disease.
on April 26, 2021 at 10:45 am
Detection of Disseminating Tumor Cells (DTCs) in bone marrow holds promise for the early detection of potential relapse, decreasing overall survival rate. SANTA CLARA, CALIFORNIA, UNITED STATES, April ...
Innovation and Tradition at the University of Pennsylvania School of Medicine: An Anecdotal Journey
on April 22, 2021 at 1:44 am
From the time of its establishment in the eighteenth century until late in the nineteenth century, the University of Pennsylvania's School of Medicine was ...

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Perelman School of Medicine at the University of Pennsylvania Research

Perelman School of Medicine 2021 Teaching Awards - UPENN Almanac
April 13, 2021
Penn Medicine: Nearly $7 Million to Study Influenza Viruses - UPENN Almanac
April 27, 2021
Penn Medicine Awarded Nearly $7 Million for First Year of Contract to Study Influenza Viruses - Newswise
April 15, 2021
Penn Medicine and Children’s Hospital of Philadelphia to Host Symposium on the Future of Cell and Gene Therapies - Newswise
April 28, 2021
Four Penn faculty elected to the National Academy of Sciences | Penn Today - Penn Today
April 28, 2021

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Perelman School of Medicine at the University of Pennsylvania Discovery

Four Penn faculty elected to the National Academy of Sciences
on April 29, 2021 at 4:58 am
Four members of the University of Pennsylvania faculty have been elected to the United States National Academy of Sciences (NAS). They are Marisa Bartolomei and M. Celeste Simon from the Perelman ...
Department of Pharmacology and Physiology
on April 26, 2021 at 5:00 pm
We offer both traditional, research-intensive graduate programs in Pharmacology and Physiology (MS and PhD), as well as a recently developed program in Drug Discovery ... Center at the University of ...
Nimbus Therapeutics Expands Development Team to Advance Multiple Portfolio Programs Through Clinical Testing
on April 21, 2021 at 8:00 am
Nimbus Therapeutics announces the expansion of its development team with the appointment of accomplished professionals in key development positions.
Penn professor Carl June receives Sanford Lorraine Cross award for cancer cell therapy
on April 18, 2021 at 6:10 pm
Perelman School of Medicine professor Carl ... Larry Jameson, executive vice president of the University of Pennsylvania Health System and dean of the Medical School, told Penn Medicine News that the ...
The chillest ape: How humans evolved a super-high cooling capacity
on April 14, 2021 at 11:46 pm
Researchers have discovered how a uniquely high density of sweat glands evolved in the human genome. Researchers showed that the higher density of sweat glands in humans is due mostly to accumulated ...