Identified: Proteins that protect against joint inflammation

Zsolt Kasza, Sudeepta Kumar Panda, Long Jiang, Fredrik Wermeling, Sanjay Boddul, Yunbing Shen and Vaishnavi Iyer at the Wermeling laboratory, the Department of Medicine, Karolinska Institutet, Solna. Photo: Erik Holmgren

Article Highlights

Proteins that protect against joint inflammation identified
Endogenous proteins that play a vital part in allergies and parasitic infection can prevent the immune system from wrongly attacking the body and causing inflamed joints
immune cells can sometimes wrongly attack the body, resulting in what are called autoimmune diseases. These diseases are often serious and affect some five per cent of the population
Researchers at Karolinska Institutet have now discovered that certain proteins called IL-4 and IL-13 can play an important part in preventing autoimmune attacks. The proteins, which are secreted by immune cells in the presence of allergens or parasitic infections, influence the behaviour of a specific type of immune cell called a neutrophil. Neutrophils are commonly the most abundant immune cells found in the actively inflamed joints of patients with rheumatoid arthritis. They are particularly virulent against tissue since they can secrete various fairly non-specific tissue irritants
Previous research has shown that IL-4 and IL-13 can affect arthritis in experimental models, but exactly how they do so has remained a mystery. The results of this latest study show that these proteins prevent neutrophils from migrating into the inflamed joint. The presence of IL-4 or IL-13 also stimulates an increase in neutrophil surface receptors which have an inhibiting effect on joint inflammation
“We will continue to study these mechanisms and hope that our work can contribute to the development of treatments for rheumatoid arthritis”

The Complete Story: Proteins that protect against joint inflammation identified

Karolinska Institutet

Go deeper with Bing News on:

Rheumatoid arthritis

Rheumatoid arthritis symptoms: The sensation of 'sand in eye' is a telltale sign
on March 5, 2021 at 2:03 pm
RHEUMATOID arthritis mainly affect the joints but the symptoms do not stop there. Occasionally, eye problems can signal the joint condition, which include the sensation of sand in the eye.
Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation
on March 5, 2021 at 7:08 am
Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases with several pathogenic pathways in common. Evidence supports an association between the diseases, but the exact ...
Care Disparities Persist Among White, Minority Patients With Rheumatoid Arthritis
on March 4, 2021 at 2:56 pm
A recent study found that patients living in an an area with low socioeconomic status were less likely to be prescribed biological disease-modifying antirheumatic drugs if they were considered ...
Rheumatoid arthritis symptoms: Lumps under skin of bony areas is a warning sign
on March 2, 2021 at 11:46 am
RHEUMATOID arthritis is an autoimmune disease that causes a number of joint problems. Lumps under the skin of bony areas can signal you have rheumatoid arthritis.
Rheumatoid arthritis decreases risk for Parkinson’s disease: a Mendelian randomization study
on March 2, 2021 at 3:14 am
Epidemiological and clinical studies have suggested comorbidity between rheumatoid arthritis and Parkinson’s disease (PD), but whether there exists a causal association and the effect direction of ...

Go deeper with Google Headlines on:

Rheumatoid arthritis

Treating rheumatoid arthritis with micromotors - Science Daily
February 24, 2021
Rheumatoid Arthritis and Acne: What's the Connection? - Healthline
February 25, 2021
Two-year delay in diagnosis common for patients with psoriatic arthritis - Healio
March 3, 2021
Assessing Fatigue in Rheumatoid Arthritis - Rheumatology Advisor
February 17, 2021
Benefits of Hydrotherapy Treatments for Rheumatoid Arthritis - Healthline
February 25, 2021

Go deeper with Bing News on:

Joint inflammation

The gut–joint axis in rheumatoid arthritis
on March 5, 2021 at 8:54 am
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that primarily affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at mucosal sites as a ...
Study shows less than 1% of pro athletes infected by COVID-19 also developed inflammatory heart disease
on March 4, 2021 at 8:43 am
A recent study has revealed that out of 789 professional athletes infected with COVID-19, only five of them had inflammatory heart disease.
MLS releases joint statement on JAMA Cardiology study
on March 4, 2021 at 8:18 am
Major League Soccer on Thursday released a joint statement with MLB, NBA, NHL, NFL and WNBA on a study by JAMA Cardiology on the prevalence of inflammatory heart disease among professional athletes ...
Joint Statement on behalf of MLB, MLS, NBA, NHL, NFL and WNBA
on March 4, 2021 at 8:05 am
The official source for NFL news, video highlights, fantasy football, game-day coverage, schedules, stats, scores and more.
GSDME-mediated pyroptosis promotes inflammation and fibrosis in obstructive nephropathy
on March 3, 2021 at 4:00 pm
Specific deletion Hmgb1 in renal tubular cells reduced fibrosis progression and inflammatory cells infiltration in the R-UUO model. Fig. 8: Caspase3 cleaved GSDME in over-expressing GSDME of renal ...