Eradicating deadly staph using a new breed of antibiotics has revealed promising results in research released by QUT, to help overcome one of the biggest modern medical challenges.
The bacteria attach to medical devices including catheters, artificial joints, implants and patients’ burns and wounds, establishing bacterial biofilms, a leading cause of failing antibiotic therapies and chronic infections.
QUT researchers have developed hybrid antibiotics designed to penetrate the slimy shield protecting invasive golden staph (Staphylococcus aureus) infections.
Led by Associate Professor Makrina Totsika and PhD student Anthony Verderosa (pictured below), the research has been published in top infectious diseases journal Antimicrobial Agents and Chemotherapy.
The study found hybrid antibiotics worked well by destroying Staph biofilms grown in the lab.
“Biofilms are a sticky, slimy coating that often prevents conventional antibiotics from accessing bacterial cells,” Mr Verderosa said.
“We have developed a new breed of antibiotic that tricks biofilms into releasing their protected cells allowing access through the protective slimy coating of the biofilm.
“This allows for the biofilms to be eradicated.”
He said the microscopic compound emits a fluorescence signal enabling researchers to watch the drug penetrating the biofilm, either killing the bacteria directly or leaving them susceptible to killing.
Associate Professor Totsika said the majority of infections, even those not associated with an implanted medical device, involve biofilms in some way so the potential for these drugs is wide.
“We are now gearing up to do pre-clinical testing,” she said.
“What is promising is the fact that our compounds are hybrids of drugs that are already in clinical use as stand-alone therapies, such as conventional antibiotics and nitroxides, so this offers hope that they could be translated into clinical therapies in the not so distant future.”
Hospital acquired infections and increasing resistance to antibiotics has challenged medical researchers to find and test novel antimicrobial agents, including alternatives to antibiotics.
The World Health Organisation has identified antibiotic resistant pathogens as one of the “biggest threats to global health today”.
Associate Professor Totsika said there was scope to apply the research beyond medicine, to agriculture, biotechnology and other industries.
Go deeper with Bing News on:
- No Benefit for Longer-Duration Antibiotic Prophylaxis After Limb Salvage
There was, however, a significantly higher risk of clinically serious antibiotic-related complications ... harm," she said in a presentation at the hybrid Musculoskeletal Tumor Society annual ...
- Qumulo Named a Leader in Gartner® Magic Quadranttm for Distributed File Systems and Object Storage for Four Years in a Row
Qumulo, the breakthrough leader in radically simplifying enterprise file data management across hybrid cloud environments, today announced its position as a Leader in the 2021 Gartner Magic Quadrant ...
- Insects & Spiders Seem to Carry & Spread Antibiotic Resistance
Antibiotic resistance is seen as a growing threat to public health, and scientists have been trying to develop new antibiotics to combat the problem. While antibiotic resistant infections are already ...
- Climate change goes nuclear: Melting Arctic permafrost could unleash radioactive waste from atom bomb tests and scuttled Cold War submarines, viruses and antibiotic-resistant ...
As the permafrost thaws, there is potential for these bacteria to mix with meltwater and create new antibiotic-resistant strains of existing viruses. More than 100 microorganisms in the deep ...
- Species line-up for Artstation challenge: Untamed
Most of the species we see today suffer a massive extinction event called the “Happy Days”. Afterwards, no one was sure what happened, but it seemed like all of man’s worst fears were realized; famine ...
Go deeper with Google Headlines on:
Go deeper with Bing News on:
- Study: Berberine, A Natural Anti-Staphylococcal Agent, Can Be Used To Treat Prosthetic Joint Infections
Study: Berberine, A Natural Anti-Staphylococcal Agent, Can Be Used To Treat Prosthetic Joint Infections. News Target \| Natural News. October 11th, 2021 \| 16 ...
- Brooke Shields On How She Harnessed Her Inner Strength After A Devastating Leg Injury
The actress had fractured her femur falling off a balance board at the gym. Two surgeries later, her ordeal wasn’t over. Just days after being discharged from the hospital, she had to return due to a ...
- Brooke Shields Says She Had 'Mini Panics Every Day' After Devastating Leg Injury
Brooke Shields says that after she broke her femur, she was experiencing "mini panic attacks" every day. Here's how she learned to harness her inner strength.
- Was Holt boy's life-threatening illness COVID-related MIS-C? Doctors can't say for sure
Logan Bouvier spent two weeks in the hospital with a serious illness. Doctors can't definitively say if a syndrome associated with COVID was cause.
- MRSA, five other ‘superbugs’ infections resulted in more than 11,000 deaths among seniors
By NewsDesk @infectiousdiseasenews New research published by The Pew Charitable Trusts, University of Utah, and Infectious Diseases Society of America showed that in 2017, infections caused by six ...