via CTV News
Investigators designed a capsule that can be swallowed once a month, reside in the stomach and release a drug to prevent pregnancy
Daily oral contraceptive pills allow women to manage their fertility, but this method of contraception relies on a user remembering to take her pill at the same time every day. In a multi-national survey, up to half of women taking an oral contraceptive reported missing at least one dose over a three-month period. Among women using oral contraceptive pills, the chance of pregnancy is about 9 percent every year. A team led by investigators from Brigham and Women’s Hospital and MIT is designing a new method to help improve adherence and reduce the risk of pregnancy by offering an oral contraceptive that could be taken once a month. Building on previous research to develop slow-release pills that can reside in the stomach for days or weeks, the team reports in Science Translational Medicine that, for the first time, it has achieved month-long delivery in preclinical models.
“Our capsule represents a major advancement toward providing women with a once-a-month contraceptive. For many, this may be hard to believe. But our preclinical data is encouraging us along that road,” said co-corresponding author Giovanni Traverso, MD, PhD, a gastroenterologist and physician-researcher at the Brigham and MIT. “We began our work on extended drug release by working with treatments for malaria, tuberculosis and HIV. But early on, we were having conversations about the potential impact that extended drug release could have for family planning. We wanted to help empower women with respect to fertility control and are pleased to report our progress toward that goal.”
The team designed a drug-delivery vehicle that consists of six arms joined by an elastic-coated core. The arms were loaded with the oral contraceptive drug levonorgestrel and folded up into a capsule that can be swallowed. Once in the stomach, the arms unfold and have a span that is larger than the opening of the human pylorus, helping the system stay in the stomach where it can release the drug over time.
The research team tested the concentration of oral contraceptive over time in a pig model and measured the presence of the drug in the bloodstream for animals who had been given the extended-release form versus an immediate release tablet. For the tablet, dosage tapered off after six hours. For the extended-release form, the team observed concentrations of the drug for up to 29 days.
Work is now underway to bring the extended-release pill closer to human trials. Next steps will include scaling up manufacturing processes and safety evaluations.
Learn more: Once-A-Month Oral Contraceptive Pill in Development
Go deeper with Bing News on:
Oral contraceptive
- How does taking a pause on the oral contraceptive pill impact mental health?
Users of combination oral contraceptive agents experience one time per month (pill break) was connected with mood changes.
- Women's mood worsens during the 7 contraceptive pill-free days, study finds
Most contraceptive pills are based on a cycle of taking the pill for 21 days, and then stopping the pill for 7 days.
- Quitting Birth Control Pills Can Cause Withdrawal, Depression, Says Study
It is normal for women to feel irritable around the time of their period, but for some women, these feelings may be more pronounced ...
- Common Contraceptive Pill Advice Linked With Mental Health Decline
Other studies have suggested that taking hormonal contraceptives can actually reduce rates of panic disorder and depression. That may be particularly true for the roughly 5 percent to 8 percent of ...
- Women's mood found to worsen during 'pill pause' period of monthly contraceptive pill cycle
Most contraceptive pills are based on a cycle of taking the pill for 21 days, and then stopping the pill for 7 days. Now researchers have found that women's mood worsens during the 7 pill-free days.
Go deeper with Google Headlines on:
Oral contraceptive
[google_news title=”” keyword=”oral contraceptive” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
Go deeper with Bing News on:
Once-a-month contraceptive
- Birth control users have similar mood changes as non-users: Study
Researchers studied women taking combination-type contraceptive pills, which contain both progestin and estrogen. They found women reported significant mood deterioration during the pause or placebo ...
- How does taking a pause on the oral contraceptive pill impact mental health?
Users of combination oral contraceptive agents experience one time per month (pill break) was connected with mood changes.
- Birth Control Pill Pause-Period Steers Mood Dips in Women
During the 7 pill-free days in contraception, women experience anxiety and mental issues similar to menstrual mood swings.
- Common Contraceptive Pill Advice Linked With Mental Health Decline
Other studies have suggested that taking hormonal contraceptives can actually reduce rates of panic disorder and depression. That may be particularly true for the roughly 5 percent to 8 percent of ...
- Women's mood found to worsen during 'pill pause' period of monthly contraceptive pill cycle
Most contraceptive pills are based on a cycle of taking the pill for 21 days, and then stopping the pill for 7 days. Now researchers have found that women's mood worsens during the 7 pill-free days.
Go deeper with Google Headlines on:
Once-a-month contraceptive
[google_news title=”” keyword=”once-a-month contraceptive” num_posts=”5″ blurb_length=”0″ show_thumb=”left”]
