For the first time researchers successfully reproduced the electrical properties of biological neurons onto semiconductor chips.
Artificial neurons on silicon chips that behave just like the real thing have been invented by scientists – a first-of-its-kind achievement with enormous scope for medical devices to cure chronic diseases, such as heart failure, Alzheimer’s, and other diseases of neuronal degeneration.
Critically the artificial neurons not only behave just like biological neurons but only need one billionth the power of a microprocessor, making them ideally suited for use in medical implants and other bio-electronic devices.
The research team, led by the University of Bath and including researchers from the Universities of Bristol, Zurich and Auckland, describe the artificial neurons in a study published in Nature Communications.
Designing artificial neurons that respond to electrical signals from the nervous system like real neurons has been a major goal in medicine for decades, as it opens up the possibility of curing conditions where neurons are not working properly, have had their processes severed as in spinal cord injury, or have died. Artificial neurons could repair diseased bio-circuits by replicating their healthy function and responding adequately to biological feedback to restore bodily function.
In heart failure for example, neurons in the base of the brain do not respond properly to nervous system feedback, they in turn do not send the right signals to the heart, which then does not pump as hard as it should.
However developing artificial neurons has been an immense challenge because of the challenges of complex biology and hard-to-predict neuronal responses.
The researchers successfully modelled and derived equations to explain how neurons respond to electrical stimuli from other nerves. This is incredibly complicated as responses are ‘non-linear’ – in other words if a signal becomes twice as strong it shouldn’t necessarily elicit twice as big a reaction – it might be thrice bigger or something else.
They then designed silicon chips that accurately modelled biological ion channels, before proving that their silicon neurons precisely mimicked real, living neurons responding to a range of stimulations.
The researchers accurately replicated the complete dynamics of hippocampal neurons and respiratory neurons from rats, under a wide range of stimuli.
Professor Alain Nogaret, from the University of Bath Department of Physics led the project. He said: “Until now neurons have been like black boxes, but we have managed to open the black box and peer inside. Our work is paradigm changing because it provides a robust method to reproduce the electrical properties of real neurons in minute detail.
“But it’s wider than that, because our neurons only need 140 nanoWatts of power. That’s a billionth the power requirement of a microprocessor, which other attempts to make synthetic neurons have used. This makes the neurons well suited for bio-electronic implants to treat chronic diseases.
“For example we’re developing smart pacemakers that won’t just stimulate the heart to pump at a steady rate but use these neurons to respond in real time to demands placed on the heart – which is what happens naturally in a healthy heart. Other possible applications could be in the treatment of conditions like Alzheimer’s and neuronal degenerative diseases more generally.
“Our approach combines several breakthroughs. We can very accurately estimate the precise parameters that control any neurons behaviour with high certainty. We have created physical models of the hardware and demonstrated its ability to successfully mimic the behaviour of real living neurons. Our third breakthrough is the versatility of our model which allows for the inclusion of different types and functions of a range of complex mammalian neurons.”
Professor Giacomo Indiveri, a co-author on the study, from the University of Zurich and ETH Zurich, added: “This work opens new horizons for neuromorphic chip design thanks to its unique approach to identifying crucial analog circuit parameters.”
Another co-author, Professor Julian Paton, a physiologist at the University of Auckland and the University of Bristol, said: “Replicating the response of respiratory neurons in bioelectronics that can be miniaturised and implanted is very exciting and opens up enormous opportunities for smarter medical devices that drive towards personalised medicine approaches to a range of diseases and disabilities”.”
Go deeper with Bing News on:
- Are Brain Implants the Future of Humanity?on February 23, 2021 at 3:57 am
Scientists have been researching and developing brain implants that could connect the human brain to other devices in order to allow human beings to control things with their minds.
- Study links sleep to storing the memory of newly learned materialon February 22, 2021 at 6:29 pm
A new research suggests that sleep is vital to associating emotion with memory and that the 'reactivation' of memories during sleep needs to occur in order to fully store the memory of newly learned ...
- Neurons activated by visual stimulus keep more active during subsequent sleep, study showson February 22, 2021 at 5:35 pm
When you slip into sleep, it's easy to imagine that your brain shuts down, but University of Michigan research suggests that groups of neurons activated during prior learning keep humming, tattooing ...
- Boost your emotional health and memory with a good night’s sleep : Studyon February 22, 2021 at 2:27 pm
A research from the University of Michigan suggests that groups of neurons activated during prior learning keep humming and building memories into your brain during sleep. U-M researchers have been ...
- Sleep is vital to associating emotion with memory: Studyon February 22, 2021 at 10:29 am
A research from the University of Michigan suggests that groups of neurons activated during prior learning keep humming and building memories into your brain du ...
Go deeper with Google Headlines on:
Go deeper with Bing News on:
- Proxima Ventures and Co-win Ventures invest in Bioelectronica® Corporation to accelerate pharmaceutical discovery and developmenton February 8, 2021 at 12:40 pm
Tax Planning Personal Finance Save for College Save for Retirement Invest in Retirement Research Mutual Funds Stocks ETFs Bonds Best Investments ...
- Proxima Ventures and Co-win Ventures invest in Bioelectronica® Corporation to accelerate pharmaceutical discovery and developmenton February 8, 2021 at 12:14 pm
The team at Proxima, experienced investors in biotech and medical devices, are headed up by Founding Partners Luke Sun and George Li. Contributing to earlier financing with Co-win, whose ...
- Electro-Quasistatic Animal Body Communication for Untethered Rodent Biopotential Recordingon February 8, 2021 at 10:01 am
Continuous multi-channel monitoring of biopotential signals is vital in understanding the body as a whole, facilitating accurate models and predictions in neural research. The cur ...
- Study Supports Bioelectronic Medicine to Treat Rheumatoid Arthritison February 2, 2021 at 6:57 am
Tracey, MD, discussed a recent clinical study that used a hand-held battery-operated electronic device to treat patients suffering from moderate to severe rheumatoid arthritis (RA). Researchers in ...
- Bio Electronics & Bio Sensors Market Segmentation Application, efforts Technology & Market Analysis to 2025on January 26, 2021 at 3:14 am
The global bio electronic market is valued USD $15 billion ... high demand in implantable medical devices, increasing prevalence of neural and cardiac diseases among others. The emerging ...