Researchers at the University of Copenhagen have found a new survival mechanism for a commonly known type of bacteria. It can send out warning signals and thus make sure that other bacteria escape ‘dangers’ such as antibiotics. The researchers hope that the new knowledge can be utilised to make antibiotic treatment more effective.
A bacterial infection is not just an unpleasant experience – it can also be a major health problem. Some bacteria develop resistance to otherwise effective treatment with antibiotics. Therefore, researchers are trying to develop new types of antibiotics that can fight the bacteria, and at the same time trying to make the current treatment with antibiotics more effective.
Researchers are now getting closer to this goal with a type of bacteria called Pseudomonas aeruginosa, which is notorious for infecting patients with the lung disease cystic fibrosis. In a new study, researchers found that the bacteria send out warning signals to their conspecifics when attacked by antibiotics or the viruses called bacteriophages which kill bacteria.
‘We can see in the laboratory that the bacteria simply swim around the ‘dangerous area’ with antibiotics or bacteriophages. When they receive the warning signal from their conspecifics, you can see in the microscope that they are moving in a neat circle around. It is a smart survival mechanism for the bacteria. If it turns out that the bacteria use the same evasive manoeuvre when infecting humans, it may help explain why some bacterial infections cannot be effectively treated with antibiotics’, says researcher Nina Molin Høyland-Kroghsbo, Assistant Professor at the Department of Veterinary and Animal Sciences and part of the research talent programme UCPH-Forward.
One United Organism
In the study, which is a collaboration between the University of Copenhagen and the University of California Irvine, researchers have studied the growth and distribution of bacteria in petri dishes. Here, they have created environments that resemble the surface of the mucous membranes where an infection can occur – as is the case with the lungs of a person with cystic fibrosis.
In this environment, researchers can see both how bacteria usually behave and how they behave when they are affected by antibiotics and bacteriophages.
‘It is quite fascinating for us to see how the bacteria communicate and change behaviour in order for the entire bacterial population to survive. You can almost say that they act as one united organism’, says Nina Molin Høyland-Kroghsbo.
Possibility of Blocking
The Pseudomonas aeruginosa bacteria are such a big problem that they are found in the top category ‘critical’ in the World Health Organization’s list of bacteria, where new types of antibiotics are most urgently needed. Therefore, the researchers are excited to make new discoveries about the ways in which this type of bacteria behaves and survives.
‘Infections with this type of bacteria are a major problem worldwide with many hospitalisations and deaths. That is why we are really pleased to be able to contribute new knowledge that can potentially be used to fight these bacteria’, says Nina Molin Høyland-Kroghsbo.
However, she emphasises that it will still take a long time for the new knowledge to result in better treatment. The next step is to research how to affect the bacteria’s communication and warning signals.
‘This clears the way for the use of drugs in an attempt to prevent that the warning signal is sent out in the first place. Alternatively, you could design substances that may block the signal from being received by the other bacteria, and this could potentially make treatment with antibiotics or bacteriophage viruses more effective’, concludes Nina Molin Høyland-Kroghsbo.
The Latest Google Headlines on:
The Latest Bing News on:
- Nick Peterson and Samantha Tse named Ruth L. Kirschstein National Research Service Award recipientson January 12, 2021 at 6:51 am
Worley, MD, have each received Ruth L. Kirschstein National Research Service Awards from the National Institute of Health.
- Common microbes team up to degrade polymer compositeson January 12, 2021 at 6:36 am
Polymer composites are durable, lightweight replacements for wood, metal or other materials and are used widely in everything from pipelines and utility poles to airplanes and cars.
- Researchers identify bacterium that produces pharmaceutical all-purpose weaponon January 11, 2021 at 4:24 pm
For some years, an active substance from the leaves of an ornamental plant has been regarded as a possible forerunner of a new group of potent drugs. So far, however, it has been very laborious to ...
- Sensing bacterial communicationon January 11, 2021 at 5:33 am
They may not have mouths or even vocal chords, but tiny organisms do communicate with one another. A Florida Tech study may give researchers and students further insight into that process.
- Florida Tech Students make valuable discoveries while studying quorum sensing behavioron January 10, 2021 at 9:49 pm
Florida Tech Students make valuable discoveries while studying quorum sensing behavior researcher studies response to external stimuli, ...
- Exploring the Origins of Antibiotic Resistance Geneson January 8, 2021 at 5:00 am
Scientists in Gothenburg, Sweden, reported they have traced back the evolutionary history of antibiotic resistance genes, by comparing bacterial genomes.
- Meet the bacteria that might help treat diabeteson January 7, 2021 at 10:05 am
A recent study investigates the role of gut bacteria in type 2 diabetes. It identifies specific species that might, one day, lead to better treatments.
- Nervogen Pro Review: Is Nervogen Nerve Health Supplement Legit?on January 7, 2021 at 8:49 am
Kevin Miller, a well-known medicinal chemist in one of the largest United States universities, has prepared a special mixture of plants, herbs, and vitamins called Nervogen Pro to rejuvenate the ...
- Researchers trace back the evolutionary history of antibiotic resistance geneson January 7, 2021 at 5:16 am
By comparing thousands of bacterial genomes, scientists in Gothenburg, Sweden have traced back the evolutionary history of antibiotic resistance genes.
- Natural seaweed compound that stops the spread of bacteria could be used to create self-cleaning surfaces for banknotes and shoeson January 6, 2021 at 6:35 am
Unilever and Innova Partnerships are working on a product made from the organic compound Lactam, which can block bacteria and mould on everyday surfaces.
The Latest Google Headlines on:
New types of antibiotics
The Latest Bing News on:
New types of antibiotics
- Superbugs have an arsenal of defenses—but we've found a new way around themon January 12, 2021 at 6:21 am
Researchers have not discovered any new antibiotics in decades. But our new research, published today in Nature Microbiology, has found a way to give a second wind to the antibiotics we do have.
- Superbugs have an arsenal of defences — but we’ve found a new way around themon January 11, 2021 at 11:08 am
We found a new way to revert antibiotic resistance. It involves using phage therapy to resensitise a type of bacteria to antibiotics.
- Study shows how new antibiotic resistance genes arise from random DNA sequenceson January 8, 2021 at 4:50 am
An important and still unanswered question is how new genes that cause antibiotic resistance arise. In a new study, Swedish and American researchers have shown how new genes that produce resistance ...
- Novel imaging method reveals in vivo localization of antibiotics in infected lung tissueson January 5, 2021 at 7:26 pm
Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues.
- New Method Reveals If Antibiotics Reach Bacteria Hiding in Tissueson January 5, 2021 at 9:15 am
In their study, published in PLoS Biology the researchers developed a new imaging method to see where in infected tissues and in cells an antibiotic given to treat tuberculosis re ...
- New imaging method reveals if antibiotics reach bacteria hiding in tissueson January 5, 2021 at 7:22 am
Researchers have developed a new imaging method to see where antibiotics have reached bacteria within tissues. The method could be used to help develop more effective antibiotic treatments, reducing ...
- University of Colorado Boulder research team discovers compound that could aid in fight against antibiotic-resistant bacteriaon December 28, 2020 at 8:07 am
“We, and others, have been trying to find new antibiotics for years now ... It is a method for classifying different types of bacteria by using a chemical stain that reveals whether the stain ...
- COVID-19 pandemic gives rise to super gonorrhea strain after overuse of antibioticson December 22, 2020 at 11:29 pm
With more people turning to this type of treatment, it can fuel resistance in gonorrhea, which includes super gonorrhea that has been shown to offer high resistance against current antibiotics ...
- APAC Antibiotics Industry to 2030 - Impact of COVID-19 - ResearchAndMarkets.comon December 3, 2020 at 9:21 am
DUBLIN--(BUSINESS WIRE)--The "Asia Pacific Antibiotics Market 2020-2030 by Drug Class, Action Mechanism, Drug Origin, Activity Spectrum, Route of Administration, Drug Type, and Country ...