A test to detect opioid drugs in exhaled breath has been developed by engineers and physicians at the University of California, Davis. A breath test could be useful in caring for chronic pain patients as well as for checking for illegal drug use.
“There are a few ways we think this could impact society,” said Professor Cristina Davis, chair of the Department of Mechanical and Aerospace Engineering at UC Davis, who led the research along with Professor Michael Schivo from the UC Davis Medical Center. The work is described in a paper published in the Journal of Breath Research Oct. 3.
Doctors and nurses treating chronic pain may need to monitor patients to make sure they are taking their drugs correctly, that their prescribed drugs are being metabolized properly and that they are not taking additional medications. Blood tests are the gold standard: a reliable, noninvasive test would be a useful alternative.
Collecting droplets from breath
For the test developed by postdoctoral researcher Eva Borras, Davis and colleagues, subjects breathe normally into a specialized collection device. Droplets in breath condense and are stored in a freezer until testing. Davis’ lab uses mass spectrometry to identify compounds in the samples.
The researchers tested the technique in a small group of patients receiving infusions of pain medications including morphine and hydromorphone, or oral doses of oxycodone, at the UC Davis Medical Center. They were therefore able to compare opioid metabolites in breath with both blood samples and the doses given to patients.
“We can see both the original drug and metabolites in exhaled breath,” Davis said.
Fully validating the breath test will require more data from larger groups of patients, she said. Davis’ laboratory is working toward real-time, bedside testing.
Other authors on the paper include graduate student Andy Cheng, UC Davis forensic science program; Ted Wun, Department of Internal Medicine; Kristen Reese and Matthias Frank, Lawrence Livermore National Laboratory; and Michael Schivo, UC Davis School of Medicine and VA Northern California Health System.
Davis’ laboratory is working on a variety of applications for detecting small amounts of chemicals, especially in air and exhaled breath. Other projects include diagnosing influenza in people and citrus greening disease in fruit trees.
Learn more: A Breath Test for Opioids
The Latest on: Opioid drug test
via Google News
The Latest on: Opioid drug test
- Get Narcan to certain legally prescribed opioid patientson April 6, 2021 at 12:33 pm
Being in the drug-testing business, we talk to people and doctors in response to a variety of situations and circumstances. With that said, we have been reading the articles recently on the topic of ...
- Pharmacies Can't Escape More Trials In Opioid MDLon April 5, 2021 at 1:21 pm
Law360 (April 5, 2021, 4:14 PM EDT) -- An Ohio federal judge overseeing multidistrict litigation over the opioid crisis said Monday he won ... Judge Polster pointed out that drug manufacturers and ...
- The Opioid Crisis Was America’s Epidemic Before COVID. Research Suggests that Overdoses Hurt Student Achievementon April 5, 2021 at 4:01 am
Long before the emergence of COVID-19, the United States was struggling to contain a years-long opioid crisis that took tens of thousands of lives every year. Now, with Oxycontin manufacturer Purdue ...
- Opioid crisis in Kansas has experts asking: Who will decide allocation of McKinsey settlement money?on April 3, 2021 at 4:01 am
Fighting the opioid crisis has become a point of bipartisan agreement ... Clinics like hers have been put to the test during the COVID-19 pandemic — even as those funding and staffing challenges ...
- An opioid-sparing protocol with intravenous parecoxib can effectively reduce morphine consumption after simultaneous bilateral total knee arthroplastyon March 31, 2021 at 5:00 pm
Multimodal pain management protocol effectively relieves pain following simultaneous bilateral total knee arthroplasty (SBTKA) but is associated with administration of large amounts of opioids in the ...
- Targeted opioid that hones in on inflamed tissues stops colitis pain without side effectson March 31, 2021 at 9:56 am
NFEPP is a reengineered form of the opioid fentanyl; an added fluorine atom helps the drug to only bind to the ... If so, they plan to test NFEPP's ability to inhibit pain in the human gut and ...
- Positive roadside drug tests wrong nearly 24% of the time in Michigan pilot, data showson March 30, 2021 at 12:55 pm
Roadside drug tests piloted in Michigan last year can’t immediately tell police if a driver is high, but they are expected to detect recent ingestion of certain drugs. In some cases, however, they may ...
- Invoking MLK, Drug-Loving Columbia Professor Says He's Putting His Body on the Line to Educate the Publicon March 30, 2021 at 9:20 am
Carl Hart is a neuroscientist, drug researcher, Columbia professor, and unabashed heroin user. His recent book, Drug Use for Grown-Ups, mixes personal anecdote (heroin is hardly the only taboo drug he ...
- Opioid MDL's Tribal Bellwether Dodges Early Drug Co. Attackson March 29, 2021 at 7:57 pm
Law360 (March 29, 2021, 10:56 PM EDT) -- An Oklahoma federal judge Monday rejected sweeping attacks on one of the biggest cases blaming drug companies for opioid abuse on Native ... toward a ...
- Accredited Drug Testing Now Offers Instant Hair Drug Testing Resultson March 29, 2021 at 10:47 am
Accredited Drug Testing now offers instant result hair drug testing for mobile/onsite testing services and at many drug testing locations throughout the US.
via Bing News