The expression of many genes that have previously been associated with autism is abnormal also in violent psychopathy, a new study shows.
The researchers used stem cell technology to analyse the expression of genes and proteins in the brain cells of psychopathic violent offenders. Published in Molecular Psychiatry, the findings may open up new avenues for the treatment of psychopathy. The study was carried out in collaboration between the University of Eastern Finland, the University of Helsinki and Karolinska Institutet in Sweden.
Psychopathy is an extreme form of antisocial behaviour, with about 1% prevalence in the general population, and 10–30% prevalence among incarcerated criminal offenders. Psychopathy is known to be strongly hereditary, but whether or not it is associated with abnormal expression of genes or proteins in neurons has remained unclear– up until now.
In the newly published study, the researchers used stem cell technology to analyse the expression of genes and proteins that have been associated with psychopathy. The study participants’ skin cells were used to create pluripotent stem cells, which were then differentiated into cortical neurons and astrocytes. The study population comprised psychopathic violent offenders and healthy controls. Since psychopathy was accompanied by substance abuse, the study population also included non-psychopathic substance abusers. This made it possible for the researchers to determine which abnormalities were associated exclusively with psychopathy.
The study shows that psychopathy is associated with robust alterations in the expression of genes and immune-response-related molecular pathways. Several of these genes have also been linked to autism. In neurons, psychopathy was associated with marked upregulation of RPL10P9 and ZNF132, and downregulation of CDH5 and OPRD1. In astrocytes, RPL10P9 and MT-RNR2 were upregulated. The expression of these genes explained 30–92% of the variance of psychopathic symptoms. Psychopathy was also associated with altered expression of proteins related to glucose metabolism and the opioid system.
Several earlier studies have suggested that violent and psychotic behaviour are associated with alterations in glucose metabolism and opioidergic neurotransmission. The new findings support the idea of abnormal opioid system function being a factor underlying psychopathy. This suggests that using long-lasting injections of naltrexone or buprenorphine to balance the opioid system could be a feasible treatment for psychopathy.
Learn more: Study discovers abnormal expression of genes in psychopathy
The Latest on: Psychopathy
[google_news title=”” keyword=”psychopathy” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Psychopathy
- What If the CEO Is a Psychopath?on May 26, 2023 at 10:00 pm
Psychopath. The term often evokes a mental image of a ruthless criminal or a serial killer. It’s a reasonable stereotype. Between one quarter and one third of convicted murderers are psychopath ...
- Study finds psychopathy, narcissism linked to left-wing extremismon May 26, 2023 at 12:19 pm
ROCKFORD, Ill. (WTVO) — A new study has found left-wing extremism is linked to psychopathic tendencies and narcissism. According to the study, published in the peer-reviewed journal Current Psychology ...
- Left-wing extremism linked to psychopathy and narcissism: studyon May 25, 2023 at 12:04 pm
Individuals with dark personalities — such as high narcissistic and psychopathic traits — are attracted to certain forms of political and social activism.” ...
- A Wall Street accountant turned professional escort says she's a psychopath – and swears it's the key to making 6 figureson May 25, 2023 at 6:17 am
People who have high levels of psychopathy rarely or never feel anxiety, fear, or sadness. They also tend to come off as charming and bold, Insider previously reported. Sociopaths are more ...
- ‘Corporate psychopaths’ can lead businesses to financial ruin, new research warns. Here are 13 telltale signson May 25, 2023 at 6:05 am
Psychopathy—a neuropsychiatric disorder that features a lack of emotions and empathy, usually resulting in poor behavioral control and antisocial behavior—is often associated with criminality. But a ...
- ‘Corporate psychopaths’ lead businesses to financial ruin, new research warns. Here are 13 telltale signson May 25, 2023 at 6:00 am
Psychopaths are generally charming and intelligent at first blush, and successful psychopaths all the more so. Because of this, they’re able to work “relatively undetected in corporate society,” one ...
- Psychopathic men exhibit heightened levels of sexual coercion and suspicious jealousy in romantic relationshipson May 25, 2023 at 4:00 am
A recently published study found that men with higher levels of psychopathic traits are more likely to engage in sexual coercion and exhibit suspicious jealousy in their romantic relationships. The ...
- Do Psychopaths Run the World? The Sometimes Dark Personality Traits of Leaderson May 23, 2023 at 10:25 am
Find out 4 psychopathic personality traits of leaders. Learn which powerful individuals of the past displayed psychotic behavior.
- I used to work Wall Street — now I’m a ‘psychopath’ charging men $1.5K an houron May 22, 2023 at 7:12 pm
Mia Lee went from working on Wall Street to sleeping with married men for money — and believes she’s the best in the biz because she doesn’t experience any feelings.
- Some Psychopaths Take Cream in Their Coffeeon May 22, 2023 at 7:27 am
Historical accounts and clinical devices show plenty of evidence for the multifaceted nature of psychopathy. Thus, when researchers (or media) claim that “psychopaths prefer black coffee,” they ...
via Bing News