Biomedical researchers at KU Leuven have found a new way to study endometrial diseases such as endometriosis and cancer. They were able to grow three-dimensional cell structures from diseased tissue of patients. The biobank can be used to unravel the disorders and test drugs.
Diseases of the endometrium are an important cause of infertility. One example is endometriosis, which is characterised by growth of endometrial-like tissue outside the uterine cavity, resulting in chronic abdominal pain and painful sexual intercourse. Up to half of the patients are subfertile or infertile. Treatment usually requires surgery and permanent hormonal therapy, which is incompatible with pregnancy.
Although endometriosis affects one in ten women worldwide in their fertile years, the illness remains taboo. Public figures like actress Lena Dunham and, recently, fashion designer Alexa Chung, who both suffer from endometriosis, are trying to raise awareness about the disease.
Another important disorder is endometrial cancer, the most common gynecological cancer, with tumours growing in and from the endometrium. We need a better understanding of, and more effective treatments for both diseases. But in order to make progress, researchers have to be able to grow and study the endometrium in the lab.
In 2017, Professor Hugo Vankelecom and his team at the Department of Development and Regeneration at KU Leuven developed ‘organoids’ from a healthy endometrium. These three-dimensional cell structures are grown in a petri dish from tissue fragments and cells of clinical biopsies. The organoids accurately replicate the original endometrial tissue.
With this new study, the team have gone even further, developing organoids from a broad spectrum of endometrial diseases, including endometriosis and endometrial cancer. “The organoids form ‘avatars’, as it were, of the diseased tissue and can also be used to test the effect of drugs and new drug candidates,” senior author Hugo Vankelecom (KU Leuven) explains. “Our study shows that endometrial cancer organoids of different patients are each in a specific way sensitive to chemotherapeutic drugs. Further research will show whether such tests can be of help in the clinical treatment of individual patients. This is an example of what we call personalised medicine.”
“We now have a biobank of organoids from endometrium in healthy and diseased conditions. This can help us discover how an aberrantly functioning endometrium causes infertility and then look for treatments. Our new research model offers the potential to better understand and eventually treat uterine diseases such as endometriosis,” concludes Vankelecom.
The Latest on: Biobank
via Google News
The Latest on: Biobank
- Associations of neighbourhood housing density with loneliness and social isolation: a cross-sectional study using UK Biobank dataon November 29, 2021 at 7:14 pm
We examined associations of neighbourhood housing density with loneliness and social isolation in a UK-wide cohort by using the high-resolution UK Biobank Urban Morphometric Platform (known as UKBUMP) ...
- High Apolipoprotein B Levels Associated With Diabetes and Shorter Lifespanon November 29, 2021 at 6:30 am
Many cardiovascular diseases are related to blood lipid concentrations, and low-density lipoprotein cholesterol (LDL cholesterol) is often used to assess risks. Investigators sought more precise ways ...
- Two brain tumour cases months apart inspire fundraising effort for Tasmanian biobankon November 27, 2021 at 4:05 pm
James Ennever says the first signs that he was ill were the persistent headaches that started three years ago. Now, a fundraising effort by friends and family has led to Tasmania's first tumour ...
- Inside the Newcastle 'BioBank' of blood and tissue samples which could help cure rare cancerson November 25, 2021 at 4:41 am
A new library of blood samples and donated human tissue could transform efforts to cure rare cancers at Newcastle University - and around the world. NHS bosses approved plans for the new "store" for ...
- Multimorbidity Involving CKD Markedly Increases Hospitalisation Eventson November 19, 2021 at 8:27 am
The presence of multimorbidity is associated with increased rates of emergency hospitalisation, which go up even further when chronic kidney disease (CKD) is one of the multimorbid conditions.
- Tea and coffee consumption associated with lower risk of stroke and dementiaon November 18, 2021 at 4:24 pm
Researchers investigate the impact of coffee and tea separately and in combination on the risk of stroke and dementia.
- Coffee and Tea Consumption Linked to Lower Stroke and Dementia Riskon November 18, 2021 at 11:28 am
Drinking coffee, tea or both may be associated with a significantly lower risk of stroke and dementia, according to research published yesterday in the peer-reviewed journal Plos Medicine.
- UK Biobank whole-genome sequencing data made availableon November 18, 2021 at 3:17 am
The UK Biobank has released whole-genome sequencing data on 200,000 participants and made it widely available on a platform – Research Analysis Platform.
- Moving forward, beyond the release of Whole Genome data of 200,000 UK Biobank participants.on November 17, 2021 at 1:50 pm
Today, the #UKBiobank made the #WholeGenomeSequencing (WGS) data on 200,000 UK participants available to approved researchers. The dataset comprises five petabytes of genome-wide genetic data, ...
- Protocol Examined for Returning Results in Genomic Researchon November 17, 2021 at 6:27 am
Blout Zawatsky, from Brigham and Women’s Hospital in Boston, and colleagues analyzed genomic results from 36,417 participants in the Mass General Brigham Biobank who underwent research array-based ...
via Bing News