via The Physiological Society
Gut diseases such as inflammatory bowel disease (IBD) are increasingly prevalent worldwide, especially in industrialised countries. In 2015 alone, 250,000 people in the UK were diagnosed with IBD, and 3 million in the United States (1, 2). Symptoms can include pain and swelling of the stomach, bloody diarrhoea, weight loss and extreme tiredness.
A new study in Experimental Physiology proposes a novel, non-invasive test for assessing gut function that may help screen and monitor treatment of gut diseases using only a small sample (1 mL) of blood and stool. How well your gut functions is determined by the gut-blood barrier , a complex multi-layer system. This can be compared to a fine-tuned filter that precisely controls the passage of nutrients and prevents bacteria passing from inside the bowel into the bloodstream.
In those with IBD, and other intestinal diseases, the gut-blood barrier is impaired. Here the intestinal wall is more like a ripped sieve, allowing more bacterial products to pass from the gut into the blood. This is commonly referred to as a leaky gut.
This test measures the concentration of gut bacterial products (produced by bacteria during metabolism) in the patient’s blood and stool. The authors believe that with further research this assessment of gut leakage will be very important in the diagnosis and treatment of IBD and other intestinal diseases.
The usual strategy for diagnosing and monitoring IBD is based on a colonoscopy, which is invasive, often requires anaesthesia, and assesses structural lesions, rather than gut malfunction. Gut disorders can happen before there are visible structural changes, so diagnosing based on functional tests evaluating gut leakage could allow clinicians to detect the disease earlier. While there is no cure for IBD, it is controllable. Early diagnosis would enable patients to control symptoms before they became severe, improving their quality of life.
This new research provides a non-invasive, simple test that could not only be useful for diagnosing IBD, but also other gut disorders, such as celiac disease and food allergies. It’s also helpful for detecting diseases that result in a leaky gut, such as heart failure, high blood pressure and liver ailments.
Marcin Ufnal, senior author on the study said:
“This may be a very important tool for diagnosis and treatment of gut and other diseases, using the leaky gut as a marker for disease, as well as a potential target for treatment. “
Learn more: New, non-invasive test for bowel diseases
The Latest on: Gut diseases
via Google News
The Latest on: Gut diseases
- Your Gut May Reveal This Surprising Thing About Your Chronic Disease Risk, Science Sayson January 21, 2021 at 12:25 pm
A recent study reveals how gut bacteria may help indicate our risk for chronic disease. Find out more about what this new research uncovered, here.
- Study examines association between gut mycobiome and Parkinson’s diseaseon January 21, 2021 at 10:11 am
The bacterial gut microbiome is strongly associated with Parkinson's disease (PD), but no studies had previously investigated he role of fungi in the gut.
- Study suggests that gut fungi are not associated with Parkinson's diseaseon January 21, 2021 at 9:46 am
The bacterial gut microbiome is strongly associated with Parkinson's disease (PD), but no studies had previously investigated he role of fungi in the gut. In this novel study published in the Journal ...
- Leaky Gut Revive Reviews Amy Myers MD - Does It Help To Maintain Healthy Gut Lining? Review by HealthyRexon January 20, 2021 at 4:28 pm
Cullen Ln, Austin, TX 78748 // KISSPR // The Leaky Gut Revive review will help you know about the Leaky Gut Revive. It’s a powdered supplement to treat leaky gut, constipation, and other digestive ...
- Gut bacteria help digest dietary fiber, release important antioxidanton January 20, 2021 at 5:48 am
Dietary fiber found in grains is a large component of many diets, but little is understood about how we digest the fiber, as humans lack enzymes to break down the complex molecules. Some species of ...
- Intimate links between diet, gut microbes, and health identifiedon January 19, 2021 at 8:18 am
New research suggests that scientists could soon create personalized diets that adjust the gut microbiota of individuals to optimize their health.
- Poor Gut Health Connected to Severe COVID-19on January 19, 2021 at 4:44 am
Gut dysfunction—and its associated leaky gut—may exacerbate the severity of infection by enabling the virus to access the surface of the digestive tract and internal organs.
- This common food may increase risk of dangerous bowel diseaseson January 19, 2021 at 3:02 am
In a recent study at Stony Brook University, researchers found that consumption of fructose may worsen intestinal inflammation common to inflammatory bowel diseases (IBD). The study is published ...
- Study sheds light on the causes of debilitating gut painon January 19, 2021 at 12:11 am
A new study, published in the journal Nature, reports evidence from mice and humans that a novel mechanism contributes to chronic gut pain.
- Gut Microbiome Predicts Nivolumab Efficacy in Gastric Cancer?on January 18, 2021 at 4:40 am
Preliminary data suggest that the diversity of the gut microbiome could potentially predict nivolumab response for patients with gastric cancer.
via Bing News
 are increasingly prevalent worldwide, especially in industrialised countries. In 2015 alone, 250,000 peopl){kind=link}