Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry.
The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. A newly formed company, Stemson Therapeutics, has licensed the technology.
More than 80 million men, women and children in the United States experience hair loss. Genetics, aging, childbirth, cancer treatment, burn injuries and medical disorders such as alopecia can cause the condition. Hair loss is often associated with emotional distress that can reduce quality of life and lead to anxiety and depression.
“Our new protocol described today overcomes key technological challenges that kept our discovery from real-world use,” says Alexey Terskikh, Ph.D., an associate professor in Sanford Burnham Prebys’ Development, Aging and Regeneration Program and the co-founder and chief scientific officer of Stemson Therapeutics. “Now we have a robust, highly controlled method for generating natural-looking hair that grows through the skin using an unlimited source of human iPSC-derived dermal papilla cells. This is a critical breakthrough in the development of cell-based hair-loss therapies and the regenerative medicine field.”
Terskikh studies a type of cell called dermal papilla. Residing inside the hair follicle, these cells control hair growth, including hair thickness, length and growth cycle. In 2015, Terskikh successfully grew hair underneath mouse skin (subcutaneous) by creating dermal papilla derived from human pluripotent stem cells—a tantalizing but uncontrolled process that required further refinement.
The approach detailed in the ISSCR presentation, which was delivered by lead researcher Antonella Pinto, Ph.D., a postdoctoral researcher in the Terskikh lab, features a 3D biodegradable scaffold made from the same material as dissolvable stitches. The scaffold controls the direction of hair growth and helps the stem cells integrate into the skin, a naturally tough barrier. The current protocol relies on mouse epithelial cells combined with human dermal papilla cells. The experiments were conducted in immunodeficient nude mice, which lack body hair.
The derivation of the epithelial part of a hair follicle from human iPSCs is currently underway in the Terskikh lab. Combined human iPSC-derived epithelial and dermal papilla cells will enable the generation of entirely human hair follicles, ready for allogenic transplantation in humans. Distinct from any other approaches to hair follicle regeneration, human iPSCs provide an unlimited supply of cells and can be derived from a simple blood draw.
“Hair loss profoundly affects many people’s lives. A significant part of my practice involves both men and women who are seeking solutions to their hair loss,” says Richard Chaffoo, M.D., F.A.C.S., a triple board-certified plastic surgeon who founded La Jolla Hair MD and is a medical adviser to Stemson Therapeutics. “I am eager to advance this groundbreaking technology, which could improve the lives of millions of people who struggle with hair loss.”
The technology was discovered and developed at Sanford Burnham Prebys. Further development and commercialization activities will be conducted by Stemson Therapeutics. For updates on the technology’s progress and advancement, please visit www.stemsontx.com.
Learn more: Functional hair follicles grown from stem cells
The Latest on: Induced pluripotent stem cells
[google_news title=”” keyword=”induced pluripotent stem cells” num_posts=”10″ blurb_length=”0″ show_thumb=”left”]
via Google News
The Latest on: Induced pluripotent stem cells
- Stem Cell Model of a Severe Epilepsy Syndrome Identifies a Potential Targeted Treatmenton November 22, 2023 at 1:57 am
In a new study, human induced pluripotent stem cell (IPSC) technology and gene editing were used to model SCN3A disorders, and establish mechanisms of abnormal neuronal function.
- Induced Pluripotent Stem Cell-Derived Cardiomyocyteson November 9, 2023 at 4:01 pm
Medizinische Klinik, Kardiologie, München, Germany. Induced pluripotent stem cells offer the possibility to generate patient-specific stem cell lines from individuals affected by inherited disorders.
- Pluripotent stem cells articles from across Nature Portfolioon October 29, 2023 at 5:00 pm
Embryonic stem cells and induced pluripotent stem cells are pluripotent stem cells. The authors describe an easy-to-follow bioinformatic pipeline, called EpiTyping, for the identification of ...
- Induced pluripotent stem cellon July 30, 2023 at 11:50 pm
Pluripotent stem cells hold promise in the field of regenerative medicine. Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart ...
- Perspectives for Induced Pluripotent Stem Cell Technologyon July 18, 2023 at 4:14 am
By applying this technology, it is possible to produce pluripotent stem cells from biopsy samples of arbitrarily selected individuals with various genetic backgrounds and to subsequently maintain, ...
- Induced pluripotent stem cell (iPSC) cytokineson March 14, 2023 at 12:24 am
Induced pluripotent stem cells (iPSCs) are a hopeful alternative for analyzing antigen expression in vitro and developing novel cellular therapies. iPSCs have been derived from differentiated ...
- Induced pluripotent stem cells articles from across Nature Portfolioon December 4, 2021 at 10:32 pm
Induced pluripotent stem cells (iPSCs) are pluripotent stem cells generated from adult cells by reprogramming. iPSCs have the same properties as embryonic stem cells, and therefore self-renew and ...
- Induced Pluripotent Stem Cells stock videos and footageon April 22, 2021 at 4:49 am
Red Line Reads the Sound Signal. Recording Studio, Music, Sound wave. Defocused. Blurred induced pluripotent stem cells stock videos & royalty-free footage Audio Waves on Screen. Liquid Crystal ...
via Bing News